CNRS Nantes University US2B US2B
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Should you encounter any unexpected behaviour,
please let us know.
 elNémo has been hacked on november 27th.
It has been moved away and runs again.
**Still some additional cleaning from time to time**
Sorry for the inconvenience.


***    ***

CA distance fluctuations for 260406101843209326

---  normal mode 22  ---

This matrix displays the maximum distance fluctuations between all pairs of CA atoms and between the two extreme conformations that were computed for this mode (DQMIN/DQMAX). Distance increases are plotted in blue and decreases in red for the strongest 10% of the residue pair distance changes. Every pixel corresponds to a single residue. Grey lines are drawn every 10 residues, yellow lines every 100 residues (counting from the upper left corner).

The following table indicates for every residue the two corresponding residues with the strongest CA distance fluctuations.

[HELP on distance fluctuations]

GD ok
largest increasereflargest decrease
GLY 40 0.35 ALA 208 -0.24 ALA 51
GLY 40 0.34 LEU 209 -0.27 ALA 51
GLY 40 0.32 TRP 210 -0.24 ALA 51
GLY 40 0.33 PRO 211 -0.26 ALA 51
GLY 40 0.31 PHE 212 -0.30 ALA 51
GLY 40 0.28 LEU 213 -0.27 ALA 51
GLY 40 0.27 GLY 214 -0.23 ALA 51
GLY 40 0.27 ILE 215 -0.26 ALA 51
GLY 40 0.24 VAL 216 -0.28 ALA 51
ALA 290 0.25 ALA 217 -0.23 ALA 51
ALA 290 0.23 GLU 218 -0.20 ALA 51
GLY 40 0.22 VAL 219 -0.21 ALA 51
GLY 40 0.21 LEU 220 -0.20 ARG 83
ALA 290 0.28 VAL 221 -0.18 ARG 83
ALA 290 0.20 LEU 222 -0.19 ARG 83
ARG 42 0.21 VAL 223 -0.20 ARG 83
ARG 42 0.19 THR 224 -0.19 ARG 83
HIS 339 0.20 ILE 225 -0.19 ARG 83
HIS 339 0.20 ILE 226 -0.20 ARG 83
ARG 42 0.19 PHE 227 -0.19 ARG 83
HIS 339 0.20 ILE 228 -0.18 ARG 83
HIS 339 0.23 TYR 229 -0.19 ARG 83
HIS 339 0.22 GLU 230 -0.20 ARG 83
HIS 339 0.20 LYS 231 -0.20 ARG 83
HIS 339 0.21 ARG 232 -0.20 ARG 83
HIS 339 0.24 ARG 233 -0.19 ARG 83
HIS 339 0.24 LYS 234 -0.21 PRO 190
PRO 190 0.44 GLY 7 -0.06 LEU 107
THR 187 0.49 ALA 8 -0.05 LEU 107
LEU 53 0.32 LEU 9 -0.08 LEU 197
LEU 53 0.31 LEU 10 -0.09 LEU 107
LEU 53 0.31 ARG 11 -0.11 LEU 197
LEU 53 0.34 ASP 12 -0.18 LEU 197
LEU 53 0.36 LEU 13 -0.15 LEU 197
LEU 53 0.34 VAL 14 -0.15 LEU 197
LEU 53 0.35 LEU 15 -0.20 LEU 197
LEU 53 0.39 GLY 16 -0.17 ARG 82
LEU 53 0.39 VAL 17 -0.17 ARG 82
LEU 53 0.37 LEU 18 -0.18 LEU 93
LEU 53 0.43 GLY 19 -0.21 LEU 93
LEU 53 0.49 THR 20 -0.26 LEU 93
LEU 53 0.39 ALA 21 -0.31 LEU 93
LEU 53 0.37 ALA 22 -0.34 LEU 93
LEU 53 0.53 PHE 23 -0.38 LEU 93
LEU 50 0.46 LEU 24 -0.49 LEU 93
LEU 50 0.28 LEU 25 -0.48 LEU 93
LEU 50 0.32 ASP 26 -0.53 GLN 92
LEU 50 0.45 LEU 27 -0.71 GLN 92
LEU 50 0.23 GLY 28 -0.67 GLN 92
LEU 50 0.13 THR 29 -0.53 GLN 92
ALA 46 0.21 ASP 30 -0.50 GLN 92
ALA 46 0.16 LEU 31 -0.56 LEU 91
SER 156 0.20 TRP 32 -0.54 LEU 91
SER 156 0.20 ALA 33 -0.39 LEU 91
LEU 27 0.15 ALA 34 -0.31 LEU 91
SER 156 0.20 VAL 35 -0.40 LEU 91
SER 156 0.37 GLN 36 -0.36 LEU 91
GLN 155 0.24 TYR 37 -0.29 GLU 160
ALA 51 0.16 ALA 38 -0.21 GLU 160
SER 156 0.38 LEU 39 -0.28 LEU 91
SER 156 0.60 GLY 40 -0.33 TYR 161
SER 227 0.42 GLY 41 -0.63 GLU 160
ALA 230 0.38 ARG 42 -0.87 ARG 158
ALA 51 0.46 TYR 43 -0.57 ARG 158
LEU 55 0.59 LEU 44 -0.71 SER 156
LEU 55 0.31 ALA 45 -0.44 ARG 158
LEU 27 0.31 ALA 46 -0.23 ARG 158
ALA 51 0.61 ALA 47 -0.37 SER 227
LEU 55 0.51 LEU 48 -0.48 SER 227
PHE 23 0.40 VAL 49 -0.37 ALA 230
PHE 23 0.47 LEU 50 -0.43 ALA 230
ALA 47 0.61 ALA 51 -0.53 ALA 230
LEU 48 0.48 LEU 52 -0.52 ALA 230
PHE 23 0.53 LEU 53 -0.41 ALA 230
ALA 47 0.50 GLY 54 -0.36 ALA 230
LEU 44 0.59 LEU 55 -0.36 LEU 234
LEU 44 0.42 ALA 56 -0.28 LEU 234
TYR 95 0.54 SER 57 -0.41 LEU 27
LEU 44 0.50 VAL 58 -0.34 LEU 31
LEU 44 0.48 ALA 59 -0.31 ARG 83
LEU 44 0.40 LEU 60 -0.39 GLN 61
LEU 44 0.39 GLN 61 -0.42 LEU 27
LEU 44 0.42 LEU 62 -0.41 ARG 83
LEU 44 0.39 PHE 63 -0.37 ARG 83
LEU 44 0.36 SER 64 -0.35 ARG 83
LEU 44 0.35 TRP 65 -0.46 ARG 83
LEU 44 0.35 LEU 66 -0.43 ARG 83
LEU 44 0.33 TRP 67 -0.37 ARG 83
LEU 44 0.31 LEU 68 -0.39 ARG 83
LEU 44 0.30 ARG 69 -0.45 ARG 83
LEU 44 0.30 ALA 70 -0.33 ARG 83
ASP 254 0.31 ASP 71 -0.27 ARG 83
ASP 254 0.32 PRO 72 -0.21 ARG 83
LEU 44 0.25 ALA 73 -0.16 ARG 83
LEU 44 0.24 GLY 74 -0.15 GLY 28
LEU 44 0.25 LEU 75 -0.14 TRP 32
LEU 44 0.25 HIS 76 -0.16 GLY 28
PHE 118 0.25 GLY 77 -0.27 ARG 82
ASP 119 0.28 SER 78 -0.25 ARG 82
ASP 119 0.24 GLN 79 -0.23 TRP 32
CYS 84 0.26 PRO 80 -0.31 GLY 28
PHE 118 0.16 PRO 81 -0.33 GLY 28
LEU 44 0.20 ARG 82 -0.33 GLY 28
PRO 80 0.16 ARG 83 -0.46 TRP 65
PRO 80 0.26 CYS 84 -0.33 GLY 28
LEU 44 0.22 LEU 85 -0.39 GLY 28
LEU 44 0.22 ALA 86 -0.43 GLY 28
LEU 44 0.21 LEU 87 -0.47 GLY 28
LEU 44 0.24 LEU 88 -0.49 GLY 28
LEU 44 0.30 HIS 89 -0.48 GLY 28
LEU 44 0.28 LEU 90 -0.54 GLY 28
LEU 44 0.29 LEU 91 -0.64 GLY 28
LEU 44 0.33 GLN 92 -0.71 LEU 27
ALA 47 0.32 LEU 93 -0.58 GLY 28
LEU 44 0.33 GLY 94 -0.40 GLY 28
SER 57 0.54 TYR 95 -0.36 GLY 94
GLY 54 0.49 LEU 96 -0.28 TYR 97
GLY 54 0.35 TYR 97 -0.28 LEU 96
ALA 51 0.36 ARG 98 -0.22 ARG 82
LEU 53 0.45 CYS 99 -0.21 ASP 180
LEU 53 0.39 VAL 100 -0.18 ARG 82
ALA 51 0.33 GLN 101 -0.16 ARG 82
LEU 53 0.36 GLU 102 -0.18 LEU 197
LEU 53 0.39 LEU 103 -0.17 LEU 197
LEU 53 0.34 ARG 104 -0.14 LEU 197
LEU 53 0.32 GLN 105 -0.14 LEU 197
LEU 53 0.35 GLY 106 -0.13 LEU 197
LEU 53 0.34 LEU 107 -0.10 LEU 197
LEU 53 0.30 LEU 108 -0.09 LEU 197
LEU 53 0.31 VAL 109 -0.08 LEU 195
LEU 53 0.31 TRP 110 -0.05 LEU 195
LEU 53 0.30 GLN 111 -0.05 GLY 40
LEU 53 0.27 GLN 112 -0.05 GLY 40
PRO 190 0.30 GLU 113 -0.03 GLY 40
PRO 190 0.32 GLU 114 -0.03 GLN 112
LEU 53 0.26 PRO 115 -0.06 LEU 195
SER 78 0.27 SER 116 -0.08 LEU 195
PRO 253 0.27 GLU 117 -0.09 LEU 195
PRO 253 0.27 PHE 118 -0.12 LEU 195
SER 78 0.28 ASP 119 -0.12 LEU 195
PRO 253 0.28 LEU 120 -0.13 LEU 195
PRO 253 0.32 ALA 121 -0.15 LEU 195
PRO 253 0.30 TYR 122 -0.15 GLY 196
LEU 53 0.29 ALA 123 -0.17 GLY 196
LEU 48 0.28 ASP 124 -0.20 GLY 196
MET 252 0.32 PHE 125 -0.18 GLY 196
LEU 48 0.31 LEU 126 -0.19 GLY 196
LEU 53 0.31 ALA 127 -0.19 GLY 196
LEU 48 0.29 LEU 128 -0.21 ARG 82
LEU 48 0.32 ASP 129 -0.22 ARG 82
LEU 53 0.36 ILE 130 -0.25 SER 131
LEU 48 0.30 SER 131 -0.25 ILE 130
LEU 48 0.31 MET 132 -0.26 ARG 83
LEU 48 0.36 LEU 133 -0.28 ARG 83
LEU 52 0.38 ARG 134 -0.26 LEU 93
LEU 48 0.31 LEU 135 -0.26 ARG 83
LEU 48 0.35 PHE 136 -0.29 ARG 83
LEU 52 0.41 GLU 137 -0.35 GLN 92
LEU 48 0.34 THR 138 -0.33 GLN 92
LEU 48 0.31 PHE 139 -0.27 GLN 92
LEU 48 0.41 LEU 140 -0.34 SER 57
LEU 48 0.42 GLU 141 -0.40 SER 57
LEU 48 0.28 THR 142 -0.35 GLN 92
ALA 8 0.20 ALA 143 -0.28 GLN 92
ALA 45 0.27 PRO 144 -0.26 SER 57
GLY 19 0.25 GLN 145 -0.27 GLN 92
ALA 8 0.17 LEU 146 -0.27 GLN 92
GLY 40 0.21 THR 147 -0.22 GLN 92
GLY 40 0.27 LEU 148 -0.19 LEU 53
GLY 40 0.19 VAL 149 -0.23 GLN 92
GLY 40 0.21 LEU 150 -0.24 LEU 44
GLY 40 0.36 ALA 151 -0.29 LEU 44
GLY 40 0.44 ILE 152 -0.46 LEU 44
GLY 40 0.28 MET 153 -0.48 LEU 44
GLY 40 0.34 LEU 154 -0.44 LEU 44
GLY 40 0.56 GLN 155 -0.52 LEU 44
GLY 40 0.60 SER 156 -0.71 LEU 44
LEU 310 0.33 GLY 157 -0.60 ARG 42
PRO 311 0.24 ARG 158 -0.87 ARG 42
SER 307 0.22 ALA 159 -0.71 ARG 42
TYR 161 0.24 GLU 160 -0.66 ARG 42
GLU 160 0.24 TYR 161 -0.52 GLY 41
SER 156 0.20 TYR 162 -0.42 GLY 41
MET 153 0.14 GLN 163 -0.40 ARG 42
SER 307 0.11 TRP 164 -0.38 ARG 42
PRO 315 0.10 VAL 165 -0.36 GLN 92
ARG 11 0.12 GLY 166 -0.38 GLN 92
ARG 11 0.12 ILE 167 -0.33 GLN 92
ARG 11 0.11 CYS 168 -0.34 GLN 92
ARG 11 0.15 THR 169 -0.39 GLN 92
ARG 11 0.16 SER 170 -0.38 GLN 92
ALA 8 0.14 PHE 171 -0.32 GLN 92
ARG 11 0.16 LEU 172 -0.32 GLN 92
LEU 48 0.24 GLY 173 -0.37 GLN 92
LEU 48 0.21 ILE 174 -0.32 GLN 92
LEU 48 0.17 SER 175 -0.29 LEU 93
LEU 48 0.24 TRP 176 -0.28 LEU 93
LEU 48 0.27 ALA 177 -0.30 LEU 93
LEU 48 0.22 LEU 178 -0.25 LEU 93
LEU 48 0.21 LEU 179 -0.23 LEU 93
LEU 48 0.25 ASP 180 -0.22 LEU 93
ALA 8 0.25 TYR 181 -0.23 ARG 83
ALA 8 0.21 HIS 182 -0.21 ARG 83
ALA 8 0.26 ARG 183 -0.19 ARG 82
ALA 8 0.33 ALA 184 -0.21 ILE 130
ALA 8 0.30 LEU 185 -0.21 ARG 83
ALA 8 0.29 ARG 186 -0.19 ARG 83
ALA 8 0.49 THR 187 -0.18 ASP 129
ALA 8 0.45 CYS 188 -0.19 ASP 129
ALA 8 0.40 LEU 189 -0.29 THR 281
GLY 7 0.44 PRO 190 -0.35 GLY 279
GLY 7 0.33 SER 191 -0.24 THR 281
GLY 7 0.29 LYS 192 -0.17 ARG 83
GLY 7 0.16 PRO 193 -0.15 ARG 83
ASP 250 0.13 LEU 194 -0.16 ARG 83
GLY 198 0.16 LEU 195 -0.19 ASP 124
LEU 48 0.15 GLY 196 -0.20 ASP 124
LEU 48 0.16 LEU 197 -0.20 LEU 15
LEU 195 0.16 GLY 198 -0.18 LEU 15
ASP 250 0.17 SER 199 -0.17 ARG 83
ASP 250 0.17 SER 200 -0.19 LEU 93
LEU 205 0.14 VAL 201 -0.22 LEU 93
LEU 195 0.15 ILE 202 -0.20 LEU 93
ASN 275 0.16 TYR 203 -0.20 LEU 93
LEU 48 0.13 PHE 204 -0.23 LEU 93
GLY 198 0.15 LEU 205 -0.24 GLN 92
VAL 221 0.15 TRP 206 -0.23 GLN 92
LEU 292 0.13 ASN 207 -0.24 GLN 92
ILE 297 0.14 LEU 208 -0.27 GLN 92
ILE 297 0.16 LEU 209 -0.25 GLN 92
ILE 297 0.17 LEU 210 -0.23 GLN 92
ALA 8 0.14 LEU 211 -0.24 GLN 92
ILE 297 0.14 TRP 212 -0.25 GLN 92
ILE 297 0.18 PRO 213 -0.21 GLN 92
GLY 40 0.15 ARG 214 -0.21 GLN 92
GLY 40 0.16 VAL 215 -0.22 GLN 92
GLY 40 0.18 LEU 216 -0.20 GLN 92
GLY 40 0.24 ALA 217 -0.17 ARG 83
GLY 40 0.27 VAL 218 -0.20 LEU 52
GLY 40 0.29 ALA 219 -0.18 LEU 52
GLY 40 0.33 LEU 220 -0.19 LEU 44
GLY 40 0.37 PHE 221 -0.20 ALA 51
GLY 40 0.40 SER 222 -0.26 LEU 48
GLY 40 0.49 ALA 223 -0.29 LEU 44
GLY 40 0.49 LEU 224 -0.25 LEU 44
GLY 40 0.48 PHE 225 -0.31 LEU 48
GLY 40 0.50 PRO 226 -0.42 LEU 48
GLY 40 0.43 SER 227 -0.48 LEU 48
GLY 40 0.37 TYR 228 -0.39 ALA 51
GLY 40 0.34 VAL 229 -0.39 LEU 52
ARG 42 0.38 ALA 230 -0.53 ALA 51
ARG 42 0.33 LEU 231 -0.45 ALA 51
GLY 40 0.27 HIS 232 -0.36 LEU 52
ARG 42 0.29 PHE 233 -0.39 LEU 52
ARG 42 0.33 LEU 234 -0.40 LEU 52
ARG 42 0.28 GLY 235 -0.30 LEU 52
ARG 42 0.24 LEU 236 -0.25 LEU 55
ARG 42 0.28 TRP 237 -0.29 LEU 55
ARG 42 0.28 LEU 238 -0.28 LEU 55
ARG 42 0.24 VAL 239 -0.23 LEU 55
ARG 42 0.23 LEU 240 -0.23 ARG 83
LEU 44 0.25 LEU 241 -0.25 ARG 83
ARG 42 0.24 LEU 242 -0.23 ARG 83
ARG 42 0.20 TRP 243 -0.22 ARG 83
LEU 44 0.22 VAL 244 -0.25 ARG 83
LEU 44 0.22 TRP 245 -0.25 ARG 83
ARG 42 0.20 LEU 246 -0.23 ARG 83
HIS 339 0.21 GLN 247 -0.23 ARG 83
HIS 339 0.21 GLY 248 -0.24 ARG 83
ALA 8 0.24 THR 249 -0.26 ARG 83
ALA 8 0.28 ASP 250 -0.28 ARG 83
PHE 125 0.30 PHE 251 -0.29 ARG 83
PHE 125 0.32 MET 252 -0.33 ARG 83
ALA 121 0.32 PRO 253 -0.35 ARG 83
PRO 72 0.32 ASP 254 -0.39 ARG 83
PRO 72 0.26 PRO 255 -0.35 ARG 83
PRO 72 0.24 SER 256 -0.37 ARG 83
LEU 44 0.28 SER 257 -0.39 ARG 83
LEU 44 0.28 GLU 258 -0.34 ARG 83
LEU 44 0.30 TRP 259 -0.31 ARG 83
LEU 44 0.36 LEU 260 -0.33 ARG 83
LEU 44 0.32 TYR 261 -0.32 ARG 83
LEU 44 0.30 ARG 262 -0.29 ARG 83
LEU 44 0.34 VAL 263 -0.29 ARG 83
LEU 44 0.36 THR 264 -0.29 ARG 83
LEU 44 0.29 VAL 265 -0.27 ARG 83
LEU 44 0.28 ALA 266 -0.25 ARG 83
LEU 44 0.32 THR 267 -0.25 ARG 83
LEU 44 0.26 ILE 268 -0.25 ARG 83
LEU 44 0.21 LEU 269 -0.24 ARG 83
LEU 44 0.20 TYR 270 -0.23 ARG 83
ALA 8 0.17 PHE 271 -0.22 ARG 83
ALA 8 0.17 SER 272 -0.22 ARG 83
ALA 8 0.15 TRP 273 -0.23 ARG 83
LEU 44 0.19 PHE 274 -0.24 ARG 83
ALA 8 0.19 ASN 275 -0.25 ARG 83
LEU 44 0.20 VAL 276 -0.25 ARG 83
HIS 339 0.25 ALA 277 -0.25 ARG 83
HIS 339 0.29 GLU 278 -0.26 PRO 190
HIS 339 0.32 GLY 279 -0.35 PRO 190
HIS 339 0.34 ARG 280 -0.30 PRO 190
HIS 339 0.30 THR 281 -0.34 PRO 190
GLY 283 0.35 ARG 282 -0.28 PRO 190
ARG 282 0.35 GLY 283 -0.24 PRO 190
HIS 339 0.23 ARG 284 -0.22 PRO 190
HIS 339 0.20 ALA 285 -0.23 PRO 190
VAL 221 0.22 ILE 286 -0.21 PRO 190
VAL 221 0.21 ILE 287 -0.19 ARG 83
VAL 221 0.17 HIS 288 -0.21 ARG 83
VAL 221 0.20 PHE 289 -0.21 ARG 83
VAL 221 0.28 ALA 290 -0.19 ARG 83
ALA 217 0.18 PHE 291 -0.20 ARG 83
GLY 40 0.16 LEU 292 -0.20 ARG 83
ALA 217 0.17 LEU 293 -0.19 ARG 83
GLY 214 0.23 SER 294 -0.18 ARG 83
GLY 40 0.22 ASP 295 -0.19 ARG 83
GLY 40 0.21 SER 296 -0.18 ARG 83
CYS 324 0.25 ILE 297 -0.17 ARG 83
GLY 40 0.26 LEU 298 -0.17 ARG 83
GLY 40 0.29 LEU 299 -0.18 LEU 52
GLY 40 0.27 VAL 300 -0.16 ARG 83
GLY 40 0.30 ALA 301 -0.15 ARG 83
GLY 40 0.35 THR 302 -0.17 ALA 51
GLY 40 0.36 TRP 303 -0.18 LEU 44
GLY 40 0.33 VAL 304 -0.17 LEU 44
GLY 40 0.37 THR 305 -0.16 LEU 44
GLY 40 0.43 HIS 306 -0.21 LEU 44
GLY 40 0.40 SER 307 -0.23 LEU 44
GLY 40 0.45 SER 308 -0.26 LEU 44
GLY 40 0.51 TRP 309 -0.31 LEU 44
GLY 40 0.51 LEU 310 -0.38 LEU 44
GLY 40 0.42 PRO 311 -0.51 LEU 44
SER 307 0.31 SER 312 -0.45 LEU 44
SER 307 0.26 GLY 313 -0.52 ARG 42
ALA 159 0.19 ILE 314 -0.43 ARG 42
ALA 301 0.15 PRO 315 -0.37 ARG 42
ALA 301 0.19 LEU 316 -0.31 LEU 44
ALA 301 0.18 GLN 317 -0.28 LEU 44
ALA 301 0.16 LEU 318 -0.28 ARG 42
ALA 301 0.17 TRP 319 -0.25 ARG 42
ALA 301 0.22 LEU 320 -0.20 LEU 44
ILE 297 0.21 PRO 321 -0.18 LEU 44
ILE 297 0.20 VAL 322 -0.20 ARG 42
ILE 297 0.24 GLY 323 -0.21 GLN 92
ILE 297 0.25 CYS 324 -0.19 GLN 92
ILE 297 0.20 GLY 325 -0.20 GLN 92
ILE 297 0.19 CYS 326 -0.22 GLN 92
ILE 297 0.18 PHE 327 -0.21 GLN 92
ALA 217 0.16 PHE 328 -0.20 GLN 92
ALA 217 0.15 LEU 329 -0.21 GLN 92
VAL 221 0.15 GLY 330 -0.22 GLN 92
VAL 221 0.17 LEU 331 -0.20 GLN 92
VAL 221 0.16 ALA 332 -0.19 GLN 92
VAL 221 0.15 LEU 333 -0.20 GLN 92
VAL 221 0.16 ARG 334 -0.20 ARG 83
GLY 283 0.20 LEU 335 -0.18 ARG 83
ARG 280 0.18 VAL 336 -0.18 GLN 92
GLU 278 0.17 TYR 337 -0.18 ARG 83
ARG 280 0.22 TYR 338 -0.17 ARG 83
ARG 280 0.34 HIS 339 -0.14 ARG 83
GLY 279 0.27 TRP 340 -0.15 ARG 83
GLU 278 0.20 LEU 341 -0.16 ARG 83
GLU 278 0.24 HIS 342 -0.16 ARG 83
ASP 250 0.21 PRO 343 -0.13 ARG 83

If you find results from this site helpful for your research, please cite one of our papers:

elNémo is maintained by Yves-Henri Sanejouand.
It was developed by Karsten Suhre.
Between 2003 and 2014, it was hosted by IGS (Marseille).
Between 2015 and 2025, it was hosted by US2B (Nantes).
Last modification: december 26th, 2025.