CNRS Nantes University US2B US2B
home |  start a new run |  job status |  references&downloads |  examples |  help  

Should you encounter any unexpected behaviour,
please let us know.
elNémo has been hacked on november 27th.
It has been moved away and runs again.
**Still some additional cleaning from time to time**
Sorry for the inconvenience.


***    ***

CA distance fluctuations for 260406101843209326

---  normal mode 27  ---

This matrix displays the maximum distance fluctuations between all pairs of CA atoms and between the two extreme conformations that were computed for this mode (DQMIN/DQMAX). Distance increases are plotted in blue and decreases in red for the strongest 10% of the residue pair distance changes. Every pixel corresponds to a single residue. Grey lines are drawn every 10 residues, yellow lines every 100 residues (counting from the upper left corner).

The following table indicates for every residue the two corresponding residues with the strongest CA distance fluctuations.

[HELP on distance fluctuations]

GD ok
largest increasereflargest decrease
THR 305 0.17 ALA 208 -0.22 GLY 41
THR 305 0.20 LEU 209 -0.26 GLY 41
THR 305 0.27 TRP 210 -0.24 GLY 41
VAL 304 0.23 PRO 211 -0.27 GLY 41
PRO 321 0.21 PHE 212 -0.29 GLY 41
PRO 321 0.27 LEU 213 -0.25 GLY 41
PRO 321 0.36 GLY 214 -0.22 GLY 41
PRO 321 0.31 ILE 215 -0.25 ARG 42
PRO 321 0.30 VAL 216 -0.35 GLY 235
PRO 321 0.41 ALA 217 -0.27 SER 256
PRO 321 0.39 GLU 218 -0.20 LEU 241
PRO 321 0.32 VAL 219 -0.31 VAL 239
PRO 321 0.36 LEU 220 -0.38 LEU 242
PRO 321 0.44 VAL 221 -0.23 LEU 242
PRO 321 0.37 LEU 222 -0.20 TRP 243
PRO 321 0.32 VAL 223 -0.31 TRP 243
PRO 321 0.35 THR 224 -0.26 TRP 245
PRO 321 0.35 ILE 225 -0.14 TRP 245
PRO 321 0.30 ILE 226 -0.15 GLN 247
VAL 239 0.33 PHE 227 -0.23 GLN 247
PRO 321 0.29 ILE 228 -0.14 GLN 247
PRO 321 0.25 TYR 229 -0.13 PRO 343
PRO 321 0.21 GLU 230 -0.22 PRO 343
VAL 239 0.32 LYS 231 -0.23 PRO 343
GLY 235 0.32 ARG 232 -0.27 GLU 278
GLY 235 0.17 ARG 233 -0.23 PRO 343
LEU 246 0.24 LYS 234 -0.29 PRO 343
PRO 253 0.31 GLY 7 -0.21 PRO 190
PRO 253 0.35 ALA 8 -0.30 PRO 190
PRO 253 0.32 LEU 9 -0.38 PRO 190
PRO 253 0.29 LEU 10 -0.28 PRO 190
PRO 253 0.30 ARG 11 -0.27 PRO 190
PRO 253 0.33 ASP 12 -0.36 PRO 190
PRO 253 0.29 LEU 13 -0.34 PRO 190
PRO 253 0.26 VAL 14 -0.27 PRO 190
PRO 253 0.28 LEU 15 -0.29 CYS 188
PRO 253 0.27 GLY 16 -0.36 CYS 188
PRO 253 0.23 VAL 17 -0.30 CYS 188
PRO 253 0.22 LEU 18 -0.26 CYS 188
PRO 253 0.22 GLY 19 -0.30 CYS 188
PRO 253 0.19 THR 20 -0.31 CYS 188
PRO 253 0.17 ALA 21 -0.26 CYS 188
PHE 251 0.19 ALA 22 -0.22 CYS 188
VAL 165 0.18 PHE 23 -0.26 PRO 343
GLN 92 0.23 LEU 24 -0.25 LEU 50
GLN 92 0.25 LEU 25 -0.21 PRO 343
SER 57 0.25 ASP 26 -0.22 PRO 343
SER 57 0.36 LEU 27 -0.24 LEU 50
SER 57 0.30 GLY 28 -0.20 PRO 343
SER 57 0.28 THR 29 -0.18 PRO 343
SER 57 0.28 ASP 30 -0.20 PRO 343
SER 57 0.32 LEU 31 -0.19 PRO 343
SER 57 0.26 TRP 32 -0.17 LEU 318
SER 57 0.18 ALA 33 -0.18 LEU 318
SER 57 0.16 ALA 34 -0.24 ARG 158
LEU 39 0.27 VAL 35 -0.32 ARG 158
SER 57 0.16 GLN 36 -0.41 ARG 158
GLN 36 0.15 TYR 37 -0.55 ARG 158
GLY 41 0.19 ALA 38 -0.55 ARG 158
VAL 35 0.27 LEU 39 -0.82 ARG 158
VAL 35 0.16 GLY 40 -1.20 ARG 158
ALA 38 0.19 GLY 41 -1.11 ARG 158
ALA 38 0.15 ARG 42 -0.71 ARG 158
LEU 50 0.12 TYR 43 -0.53 ARG 158
TRP 309 0.21 LEU 44 -0.37 ALA 230
TRP 309 0.24 ALA 45 -0.27 LEU 148
TRP 309 0.19 ALA 46 -0.28 ARG 158
PRO 226 0.22 ALA 47 -0.25 LEU 93
PRO 226 0.35 LEU 48 -0.27 LEU 93
PRO 226 0.27 VAL 49 -0.26 PRO 343
PRO 226 0.24 LEU 50 -0.29 LEU 93
PRO 226 0.23 ALA 51 -0.33 GLN 92
PRO 226 0.21 LEU 52 -0.29 PRO 343
LEU 31 0.20 LEU 53 -0.31 PRO 343
LEU 39 0.22 GLY 54 -0.33 GLN 92
LEU 31 0.20 LEU 55 -0.32 PRO 343
LEU 31 0.22 ALA 56 -0.35 PRO 343
LEU 27 0.36 SER 57 -0.34 PRO 343
LEU 27 0.26 VAL 58 -0.34 PRO 343
LEU 27 0.24 ALA 59 -0.35 PRO 343
LEU 27 0.27 LEU 60 -0.37 PRO 343
LEU 27 0.27 GLN 61 -0.34 PRO 343
ARG 83 0.31 LEU 62 -0.33 PRO 343
ARG 83 0.30 PHE 63 -0.37 PRO 343
ARG 83 0.31 SER 64 -0.36 PRO 343
ARG 83 0.42 TRP 65 -0.32 PRO 343
ARG 83 0.46 LEU 66 -0.33 PRO 343
ARG 82 0.46 TRP 67 -0.37 PRO 343
ARG 82 0.61 LEU 68 -0.37 PRO 190
ARG 82 0.77 ARG 69 -0.35 PRO 190
ARG 82 0.64 ALA 70 -0.34 PRO 343
ASP 254 0.64 ASP 71 -0.38 PRO 190
ASP 254 0.75 PRO 72 -0.30 PRO 190
ASP 254 0.53 ALA 73 -0.27 ALA 86
PRO 253 0.44 GLY 74 -0.25 ALA 86
PRO 253 0.52 LEU 75 -0.30 PRO 190
PRO 253 0.39 HIS 76 -0.33 PRO 190
PRO 253 0.34 GLY 77 -0.26 PRO 190
PRO 253 0.30 SER 78 -0.26 PRO 190
PRO 253 0.29 GLN 79 -0.25 PRO 190
ALA 70 0.31 PRO 80 -0.24 PRO 190
ARG 69 0.51 PRO 81 -0.19 PRO 80
ARG 69 0.77 ARG 82 -0.19 SER 78
ARG 69 0.70 ARG 83 -0.14 PRO 81
ARG 69 0.38 CYS 84 -0.23 LEU 88
ARG 69 0.20 LEU 85 -0.26 PRO 190
LEU 39 0.21 ALA 86 -0.27 ALA 73
LEU 39 0.19 LEU 87 -0.25 PRO 343
LEU 39 0.16 LEU 88 -0.26 PRO 343
LEU 39 0.21 HIS 89 -0.29 PRO 343
LEU 39 0.26 LEU 90 -0.30 SER 257
LEU 39 0.25 LEU 91 -0.30 ALA 51
GLY 28 0.28 GLN 92 -0.33 ALA 51
LEU 25 0.19 LEU 93 -0.33 GLY 54
LEU 39 0.16 GLY 94 -0.31 PRO 343
ALA 86 0.15 TYR 95 -0.32 PRO 343
VAL 165 0.12 LEU 96 -0.29 LEU 50
PRO 253 0.13 TYR 97 -0.32 PRO 190
PRO 253 0.20 ARG 98 -0.36 CYS 188
PRO 253 0.21 CYS 99 -0.36 CYS 188
PRO 253 0.19 VAL 100 -0.33 PRO 190
PRO 253 0.25 GLN 101 -0.36 PRO 190
PRO 253 0.30 GLU 102 -0.40 PRO 190
PRO 253 0.25 LEU 103 -0.37 PRO 190
PRO 253 0.24 ARG 104 -0.36 PRO 190
PRO 253 0.29 GLN 105 -0.41 PRO 190
PRO 253 0.29 GLY 106 -0.42 PRO 190
PRO 253 0.24 LEU 107 -0.36 PRO 190
PRO 253 0.23 LEU 108 -0.38 PRO 190
PRO 253 0.27 VAL 109 -0.43 PRO 190
PRO 253 0.26 TRP 110 -0.36 PRO 190
PRO 253 0.22 GLN 111 -0.34 PRO 190
PRO 253 0.22 GLN 112 -0.38 PRO 190
PRO 253 0.21 GLU 113 -0.38 PRO 190
PRO 253 0.23 GLU 114 -0.45 PRO 190
PRO 253 0.26 PRO 115 -0.48 PRO 190
PRO 253 0.27 SER 116 -0.53 PRO 190
PRO 253 0.30 GLU 117 -0.62 PRO 190
PRO 253 0.34 PHE 118 -0.56 PRO 190
PRO 253 0.33 ASP 119 -0.53 PRO 190
PRO 253 0.35 LEU 120 -0.60 PRO 190
PRO 253 0.41 ALA 121 -0.68 PRO 190
PRO 253 0.42 TYR 122 -0.55 PRO 190
PRO 253 0.38 ALA 123 -0.53 PRO 190
PRO 253 0.44 ASP 124 -0.66 CYS 188
PRO 253 0.51 PHE 125 -0.60 PRO 190
PRO 253 0.41 LEU 126 -0.50 CYS 188
PRO 253 0.40 ALA 127 -0.53 CYS 188
PRO 253 0.47 LEU 128 -0.61 CYS 188
PRO 253 0.42 ASP 129 -0.48 CYS 188
PRO 253 0.30 ILE 130 -0.44 CYS 188
PRO 253 0.30 SER 131 -0.42 PRO 343
PHE 251 0.34 MET 132 -0.47 PRO 343
PRO 253 0.23 LEU 133 -0.42 PRO 343
GLY 173 0.26 ARG 134 -0.39 PRO 343
GLY 173 0.28 LEU 135 -0.43 PRO 343
GLY 173 0.23 PHE 136 -0.40 PRO 343
SER 170 0.19 GLU 137 -0.36 PRO 343
SER 170 0.27 THR 138 -0.35 PRO 343
SER 170 0.22 PHE 139 -0.35 PRO 343
GLY 166 0.17 LEU 140 -0.33 PRO 343
ALA 59 0.18 GLU 141 -0.31 PRO 343
GLY 166 0.20 THR 142 -0.28 PRO 343
ILE 167 0.15 ALA 143 -0.27 PRO 343
PHE 227 0.16 PRO 144 -0.30 ARG 42
ALA 223 0.16 GLN 145 -0.27 ARG 42
PHE 227 0.16 LEU 146 -0.30 GLY 41
PHE 227 0.15 THR 147 -0.35 ARG 42
ALA 223 0.23 LEU 148 -0.42 ARG 42
ALA 223 0.19 VAL 149 -0.43 GLY 41
ALA 159 0.15 LEU 150 -0.48 GLY 41
ALA 223 0.20 ALA 151 -0.51 GLY 41
TRP 309 0.18 ILE 152 -0.67 GLY 41
PHE 227 0.12 MET 153 -0.71 GLY 41
ALA 301 0.15 LEU 154 -0.64 GLY 41
LEU 310 0.26 GLN 155 -0.67 GLY 41
LEU 310 0.25 SER 156 -0.94 GLY 41
SER 307 0.23 GLY 157 -0.87 GLY 41
ALA 159 0.23 ARG 158 -1.20 GLY 40
ARG 158 0.23 ALA 159 -0.79 GLY 40
SER 156 0.16 GLU 160 -0.63 GLY 40
SER 57 0.17 TYR 161 -0.32 GLY 40
SER 57 0.20 TYR 162 -0.26 LEU 318
SER 57 0.15 GLN 163 -0.39 GLY 40
ALA 159 0.20 TRP 164 -0.35 GLY 40
SER 57 0.22 VAL 165 -0.27 LEU 318
SER 57 0.23 GLY 166 -0.23 GLY 40
THR 138 0.19 ILE 167 -0.29 GLY 40
PHE 251 0.21 CYS 168 -0.26 VAL 322
THR 138 0.22 THR 169 -0.19 VAL 322
THR 138 0.27 SER 170 -0.21 GLY 41
PHE 251 0.22 PHE 171 -0.22 GLY 41
PHE 251 0.23 LEU 172 -0.16 GLY 41
LEU 135 0.28 GLY 173 -0.20 PRO 343
PHE 251 0.26 ILE 174 -0.23 THR 142
PHE 251 0.25 SER 175 -0.19 ARG 42
PHE 251 0.27 TRP 176 -0.21 PRO 343
PHE 251 0.29 ALA 177 -0.28 PRO 343
PHE 251 0.31 LEU 178 -0.29 PRO 343
PHE 251 0.29 LEU 179 -0.24 PRO 343
PHE 251 0.33 ASP 180 -0.30 PRO 343
PHE 251 0.37 TYR 181 -0.41 PRO 343
PHE 251 0.34 HIS 182 -0.43 PRO 343
PRO 253 0.35 ARG 183 -0.30 PRO 343
PHE 251 0.42 ALA 184 -0.39 PRO 343
ASP 250 0.42 LEU 185 -0.52 PRO 343
ASP 250 0.35 ARG 186 -0.43 PRO 193
PRO 253 0.40 THR 187 -0.32 GLY 16
ASP 250 0.43 CYS 188 -0.66 ASP 124
HIS 342 0.44 LEU 189 -0.55 PHE 125
HIS 342 0.48 PRO 190 -0.68 ALA 121
HIS 342 0.35 SER 191 -0.46 GLU 117
HIS 342 0.36 LYS 192 -0.38 ASP 124
HIS 339 0.13 PRO 193 -0.43 ARG 186
GLY 198 0.12 LEU 194 -0.33 ARG 186
PRO 253 0.17 LEU 195 -0.17 LEU 53
PRO 253 0.26 GLY 196 -0.18 LEU 53
PRO 253 0.26 LEU 197 -0.16 ARG 42
PRO 253 0.22 GLY 198 -0.16 ARG 42
LEU 189 0.25 SER 199 -0.18 ARG 42
ASP 250 0.26 SER 200 -0.19 ARG 42
PRO 253 0.23 VAL 201 -0.19 ARG 42
LEU 189 0.21 ILE 202 -0.19 ARG 42
ASP 250 0.24 TYR 203 -0.21 ARG 42
PHE 251 0.26 PHE 204 -0.22 ARG 42
PHE 251 0.22 LEU 205 -0.22 GLY 41
LEU 189 0.21 TRP 206 -0.24 GLY 41
PHE 251 0.23 ASN 207 -0.25 ARG 42
PHE 251 0.22 LEU 208 -0.26 GLY 41
VAL 221 0.22 LEU 209 -0.27 GLY 41
VAL 221 0.25 LEU 210 -0.28 GLY 41
VAL 221 0.23 LEU 211 -0.28 ARG 42
VAL 221 0.24 TRP 212 -0.32 GLY 41
GLY 323 0.28 PRO 213 -0.33 GLY 41
VAL 221 0.27 ARG 214 -0.31 GLY 41
VAL 221 0.22 VAL 215 -0.33 GLY 41
VAL 221 0.24 LEU 216 -0.38 GLY 41
LEU 320 0.28 ALA 217 -0.33 GLY 41
VAL 221 0.19 VAL 218 -0.35 ARG 42
VAL 221 0.17 ALA 219 -0.42 GLY 41
SER 312 0.19 LEU 220 -0.40 GLY 41
SER 312 0.14 PHE 221 -0.36 GLY 41
LEU 48 0.17 SER 222 -0.42 ARG 42
LEU 48 0.25 ALA 223 -0.45 GLY 41
LEU 48 0.25 LEU 224 -0.36 GLY 41
LEU 48 0.26 PHE 225 -0.36 GLY 41
LEU 48 0.35 PRO 226 -0.45 ARG 42
ARG 232 0.20 SER 227 -0.46 ARG 42
ARG 232 0.21 TYR 228 -0.39 ARG 42
ARG 232 0.20 VAL 229 -0.42 ARG 42
ARG 232 0.24 ALA 230 -0.43 ARG 42
ARG 232 0.28 LEU 231 -0.38 ARG 42
ARG 232 0.25 HIS 232 -0.34 ARG 42
PHE 227 0.23 PHE 233 -0.33 ARG 42
ARG 232 0.27 LEU 234 -0.30 ARG 42
ARG 232 0.32 GLY 235 -0.35 VAL 216
PHE 227 0.29 LEU 236 -0.26 ARG 42
LYS 231 0.23 TRP 237 -0.25 VAL 216
LYS 231 0.31 LEU 238 -0.32 VAL 216
PHE 227 0.33 VAL 239 -0.34 LEU 220
LYS 231 0.23 LEU 240 -0.23 PRO 343
LYS 231 0.20 LEU 241 -0.32 LEU 220
LYS 231 0.32 LEU 242 -0.38 LEU 220
LYS 231 0.21 TRP 243 -0.31 VAL 223
ARG 83 0.19 VAL 244 -0.25 PRO 343
ARG 83 0.22 TRP 245 -0.32 LEU 220
LYS 234 0.24 LEU 246 -0.24 THR 224
CYS 188 0.21 GLN 247 -0.23 PRO 343
CYS 188 0.23 GLY 248 -0.25 PRO 343
CYS 188 0.30 THR 249 -0.21 LEU 246
CYS 188 0.43 ASP 250 -0.20 LYS 231
ALA 184 0.42 PHE 251 -0.21 PRO 343
PRO 72 0.47 MET 252 -0.25 LEU 62
PRO 72 0.75 PRO 253 -0.23 LEU 90
PRO 72 0.75 ASP 254 -0.30 LEU 90
PRO 72 0.61 PRO 255 -0.28 LEU 220
PRO 72 0.57 SER 256 -0.32 LEU 220
ALA 70 0.50 SER 257 -0.30 LEU 90
PRO 72 0.41 GLU 258 -0.26 LEU 220
PRO 72 0.34 TRP 259 -0.32 LEU 220
ARG 83 0.30 LEU 260 -0.29 PRO 343
ARG 82 0.26 TYR 261 -0.31 PRO 343
ARG 83 0.24 ARG 262 -0.29 PRO 343
ARG 83 0.21 VAL 263 -0.29 PRO 343
ARG 83 0.20 THR 264 -0.35 PRO 343
ARG 83 0.18 VAL 265 -0.35 PRO 343
ARG 83 0.17 ALA 266 -0.29 PRO 343
ARG 83 0.15 THR 267 -0.29 PRO 343
SER 170 0.16 ILE 268 -0.33 PRO 343
PRO 321 0.18 LEU 269 -0.29 PRO 343
PHE 227 0.19 TYR 270 -0.25 ARG 42
ILE 226 0.17 PHE 271 -0.26 ARG 42
LEU 211 0.21 SER 272 -0.26 PRO 343
LEU 211 0.20 TRP 273 -0.28 PRO 343
ASP 250 0.23 PHE 274 -0.39 PRO 343
CYS 188 0.27 ASN 275 -0.38 PRO 343
ASP 250 0.26 VAL 276 -0.35 PRO 343
CYS 188 0.30 ALA 277 -0.34 PRO 343
CYS 188 0.32 GLU 278 -0.33 PRO 343
PRO 190 0.35 GLY 279 -0.44 PRO 343
PRO 190 0.33 ARG 280 -0.32 PRO 343
PRO 190 0.44 THR 281 -0.27 ARG 280
PRO 190 0.42 ARG 282 -0.21 LYS 234
PRO 190 0.35 GLY 283 -0.23 LYS 234
PRO 190 0.29 ARG 284 -0.19 ARG 42
PRO 190 0.31 ALA 285 -0.21 ARG 42
PRO 190 0.31 ILE 286 -0.20 ARG 42
PRO 321 0.27 ILE 287 -0.20 ARG 42
PRO 321 0.27 HIS 288 -0.21 ARG 42
VAL 221 0.30 PHE 289 -0.22 ARG 42
VAL 221 0.43 ALA 290 -0.22 ALA 301
VAL 221 0.40 PHE 291 -0.22 ARG 42
PRO 321 0.37 LEU 292 -0.24 ARG 42
CYS 324 0.48 LEU 293 -0.25 ALA 301
PRO 321 0.47 SER 294 -0.23 GLY 41
PRO 321 0.40 ASP 295 -0.25 GLY 41
LEU 320 0.49 SER 296 -0.27 GLY 41
PRO 321 0.58 ILE 297 -0.31 ALA 301
PRO 321 0.44 LEU 298 -0.26 GLY 41
LEU 320 0.30 LEU 299 -0.29 GLY 41
GLN 317 0.39 VAL 300 -0.28 GLY 41
GLN 317 0.40 ALA 301 -0.31 ILE 297
SER 312 0.26 THR 302 -0.26 GLY 41
SER 312 0.32 TRP 303 -0.29 GLY 41
SER 312 0.41 VAL 304 -0.34 PHE 327
SER 312 0.31 THR 305 -0.28 PHE 328
SER 312 0.24 HIS 306 -0.25 PHE 328
SER 312 0.38 SER 307 -0.35 CYS 324
PRO 311 0.25 SER 308 -0.36 GLN 317
LEU 48 0.25 TRP 309 -0.26 LEU 316
GLN 155 0.26 LEU 310 -0.39 GLY 41
SER 307 0.35 PRO 311 -0.64 GLY 41
VAL 304 0.41 SER 312 -0.66 GLY 40
ALA 301 0.23 GLY 313 -0.71 GLY 40
ILE 297 0.27 ILE 314 -0.63 GLY 40
ILE 297 0.31 PRO 315 -0.57 GLY 40
ILE 297 0.37 LEU 316 -0.48 GLY 41
ILE 297 0.46 GLN 317 -0.45 GLY 40
ILE 297 0.44 LEU 318 -0.47 GLY 40
ILE 297 0.42 TRP 319 -0.44 GLY 40
ILE 297 0.58 LEU 320 -0.38 GLY 41
ILE 297 0.58 PRO 321 -0.37 GLY 40
ILE 297 0.40 VAL 322 -0.37 GLY 40
LEU 293 0.40 GLY 323 -0.36 GLY 41
LEU 293 0.48 CYS 324 -0.35 SER 307
VAL 221 0.33 GLY 325 -0.31 GLY 41
VAL 221 0.29 CYS 326 -0.30 GLY 41
VAL 221 0.30 PHE 327 -0.34 VAL 304
VAL 221 0.30 PHE 328 -0.34 VAL 304
VAL 221 0.24 LEU 329 -0.26 VAL 304
VAL 221 0.23 GLY 330 -0.26 GLY 41
PRO 190 0.27 LEU 331 -0.30 VAL 304
PRO 190 0.28 ALA 332 -0.25 VAL 304
LEU 189 0.27 LEU 333 -0.22 GLY 41
LEU 189 0.32 ARG 334 -0.23 GLY 41
PRO 190 0.34 LEU 335 -0.22 VAL 304
PRO 190 0.30 VAL 336 -0.20 GLY 41
LEU 189 0.33 TYR 337 -0.20 ARG 42
PRO 190 0.42 TYR 338 -0.21 ARG 42
PRO 190 0.40 HIS 339 -0.25 ARG 280
PRO 343 0.35 TRP 340 -0.27 ARG 280
PRO 190 0.30 LEU 341 -0.25 GLY 279
PRO 190 0.48 HIS 342 -0.32 GLY 279
TRP 340 0.35 PRO 343 -0.52 LEU 185

If you find results from this site helpful for your research, please cite one of our papers:

elNémo is maintained by Yves-Henri Sanejouand.
It was developed by Karsten Suhre.
Between 2003 and 2014, it was hosted by IGS (Marseille).
Between 2015 and 2025, it was hosted by US2B (Nantes).
Last modification: december 26th, 2025.