CNRS Nantes University US2B US2B
home |  start a new run |  job status |  references&downloads |  examples |  help  

Should you encounter any unexpected behaviour,
please let us know.
elNémo has been hacked on november 27th.
It has been moved away and runs again.
**Still some additional cleaning from time to time**
Sorry for the inconvenience.


***    ***

CA distance fluctuations for 260406101843209326

---  normal mode 30  ---

This matrix displays the maximum distance fluctuations between all pairs of CA atoms and between the two extreme conformations that were computed for this mode (DQMIN/DQMAX). Distance increases are plotted in blue and decreases in red for the strongest 10% of the residue pair distance changes. Every pixel corresponds to a single residue. Grey lines are drawn every 10 residues, yellow lines every 100 residues (counting from the upper left corner).

The following table indicates for every residue the two corresponding residues with the strongest CA distance fluctuations.

[HELP on distance fluctuations]

GD ok
largest increasereflargest decrease
THR 305 0.50 ALA 208 -0.45 LEU 44
THR 305 0.36 LEU 209 -0.36 LEU 44
CYS 324 0.33 TRP 210 -0.36 LEU 44
LEU 299 0.28 PRO 211 -0.37 LEU 44
CYS 324 0.22 PHE 212 -0.30 LEU 44
CYS 324 0.24 LEU 213 -0.25 LEU 44
SER 294 0.28 GLY 214 -0.29 LEU 44
PRO 144 0.26 ILE 215 -0.27 LEU 44
PRO 144 0.29 VAL 216 -0.15 LEU 44
PRO 144 0.22 ALA 217 -0.23 ALA 301
PRO 144 0.22 GLU 218 -0.24 ALA 301
PRO 144 0.29 VAL 219 -0.18 LEU 44
GLY 235 0.31 LEU 220 -0.18 ALA 301
TRP 259 0.20 VAL 221 -0.23 ALA 301
GLU 141 0.19 LEU 222 -0.21 LEU 44
TRP 259 0.24 VAL 223 -0.17 ALA 301
LEU 242 0.25 THR 224 -0.15 ALA 301
GLU 141 0.16 ILE 225 -0.16 LEU 44
GLU 141 0.15 ILE 226 -0.19 LEU 44
TRP 259 0.15 PHE 227 -0.17 LEU 44
ILE 225 0.16 ILE 228 -0.14 LEU 44
ARG 233 0.13 TYR 229 -0.17 LEU 44
PRO 343 0.16 GLU 230 -0.20 LEU 44
PRO 193 0.16 LYS 231 -0.19 LEU 44
ILE 225 0.11 ARG 232 -0.19 PRO 255
ILE 287 0.17 ARG 233 -0.28 PRO 255
GLY 283 0.19 LYS 234 -0.40 GLY 248
VAL 100 0.17 GLY 7 -0.35 GLU 117
CYS 99 0.18 ALA 8 -0.43 GLU 117
VAL 100 0.21 LEU 9 -0.34 GLU 117
VAL 100 0.24 LEU 10 -0.25 GLU 117
LEU 96 0.22 ARG 11 -0.33 GLU 117
CYS 99 0.25 ASP 12 -0.36 LEU 120
VAL 100 0.28 LEU 13 -0.28 LEU 120
LEU 93 0.28 VAL 14 -0.24 GLU 117
LEU 93 0.25 LEU 15 -0.30 LEU 120
LEU 96 0.31 GLY 16 -0.30 GLY 106
LEU 96 0.37 VAL 17 -0.29 GLY 106
LEU 93 0.33 LEU 18 -0.22 LEU 120
LEU 93 0.30 GLY 19 -0.24 ALA 123
LEU 93 0.41 THR 20 -0.26 LEU 103
LEU 93 0.41 ALA 21 -0.25 LEU 107
GLN 92 0.36 ALA 22 -0.20 LEU 107
GLN 92 0.41 PHE 23 -0.22 LEU 103
GLN 92 0.48 LEU 24 -0.24 LEU 103
GLN 92 0.41 LEU 25 -0.18 LEU 107
GLN 92 0.37 ASP 26 -0.17 GLY 106
GLN 92 0.40 LEU 27 -0.23 VAL 35
LEU 91 0.36 GLY 28 -0.19 LEU 103
LEU 91 0.27 THR 29 -0.14 LEU 107
ALA 230 0.30 ASP 30 -0.22 VAL 35
ALA 47 0.36 LEU 31 -0.27 VAL 35
TYR 43 0.25 TRP 32 -0.20 GLY 40
SER 156 0.23 ALA 33 -0.18 ARG 42
ALA 46 0.37 ALA 34 -0.32 LEU 53
TYR 43 0.45 VAL 35 -0.43 GLY 54
SER 156 0.34 GLN 36 -0.30 GLY 41
SER 156 0.31 TYR 37 -0.35 LEU 50
VAL 35 0.33 ALA 38 -0.51 LEU 50
SER 156 0.46 LEU 39 -0.57 GLY 54
SER 156 0.87 GLY 40 -0.29 GLY 54
TRP 309 0.14 GLY 41 -0.37 GLU 160
LEU 44 0.15 ARG 42 -0.82 ARG 158
VAL 35 0.45 TYR 43 -0.49 PRO 226
LEU 31 0.24 LEU 44 -0.78 ILE 152
GLY 40 0.17 ALA 45 -0.47 LEU 148
ALA 34 0.37 ALA 46 -0.42 ALA 38
LEU 31 0.36 ALA 47 -0.44 ALA 38
LEU 31 0.19 LEU 48 -0.46 PRO 144
ALA 230 0.28 VAL 49 -0.35 ALA 38
ALA 47 0.24 LEU 50 -0.57 LEU 39
SER 256 0.25 ALA 51 -0.53 LEU 39
LEU 234 0.36 LEU 52 -0.41 LEU 140
LEU 234 0.34 LEU 53 -0.43 LEU 39
SER 256 0.34 GLY 54 -0.57 LEU 39
SER 256 0.36 LEU 55 -0.48 LEU 39
LEU 234 0.33 ALA 56 -0.39 LEU 39
ASP 26 0.29 SER 57 -0.42 LEU 39
SER 256 0.35 VAL 58 -0.44 LEU 39
SER 256 0.31 ALA 59 -0.38 LEU 39
PRO 190 0.27 LEU 60 -0.35 LEU 39
PRO 190 0.27 GLN 61 -0.36 LEU 39
PRO 190 0.27 LEU 62 -0.34 LEU 39
PRO 190 0.31 PHE 63 -0.32 LEU 39
PRO 190 0.32 SER 64 -0.32 LEU 39
ARG 83 0.32 TRP 65 -0.30 LEU 39
ARG 83 0.31 LEU 66 -0.27 LEU 39
PRO 190 0.31 TRP 67 -0.28 LEU 39
ARG 83 0.31 LEU 68 -0.28 LEU 39
ARG 83 0.43 ARG 69 -0.25 LEU 39
ARG 83 0.32 ALA 70 -0.24 LEU 39
ARG 83 0.26 ASP 71 -0.25 LEU 39
ARG 83 0.26 PRO 72 -0.27 ALA 184
ARG 83 0.35 ALA 73 -0.24 ALA 184
ARG 82 0.23 GLY 74 -0.22 LEU 39
PRO 190 0.23 LEU 75 -0.24 LEU 39
PRO 190 0.26 HIS 76 -0.25 LEU 39
ARG 82 0.36 GLY 77 -0.23 LEU 39
ARG 82 0.30 SER 78 -0.25 LEU 39
SER 191 0.22 GLN 79 -0.28 LEU 39
PRO 81 0.23 PRO 80 -0.27 LEU 39
PRO 80 0.23 PRO 81 -0.23 LEU 39
GLY 77 0.36 ARG 82 -0.26 LEU 39
ARG 69 0.43 ARG 83 -0.26 LEU 39
PRO 190 0.22 CYS 84 -0.29 LEU 39
PRO 190 0.25 LEU 85 -0.29 LEU 39
LEU 24 0.27 ALA 86 -0.28 LEU 39
LEU 24 0.30 LEU 87 -0.30 LEU 39
LEU 24 0.31 LEU 88 -0.33 LEU 39
LEU 24 0.32 HIS 89 -0.34 LEU 39
LEU 24 0.37 LEU 90 -0.34 LEU 39
LEU 24 0.45 LEU 91 -0.38 LEU 39
LEU 24 0.48 GLN 92 -0.41 LEU 39
LEU 24 0.43 LEU 93 -0.38 LEU 39
PRO 190 0.28 GLY 94 -0.35 LEU 39
CYS 188 0.31 TYR 95 -0.37 LEU 39
VAL 17 0.37 LEU 96 -0.37 LEU 39
PRO 190 0.29 TYR 97 -0.34 LEU 39
CYS 188 0.34 ARG 98 -0.32 LEU 39
CYS 188 0.33 CYS 99 -0.29 LEU 39
CYS 188 0.29 VAL 100 -0.29 LEU 39
PRO 190 0.29 GLN 101 -0.28 LEU 39
CYS 188 0.33 GLU 102 -0.25 LEU 39
CYS 188 0.27 LEU 103 -0.26 THR 20
SER 191 0.24 ARG 104 -0.23 LEU 39
SER 191 0.26 GLN 105 -0.22 LEU 39
SER 191 0.24 GLY 106 -0.30 GLY 16
ARG 82 0.18 LEU 107 -0.28 VAL 17
SER 191 0.19 LEU 108 -0.20 VAL 17
SER 191 0.20 VAL 109 -0.22 VAL 17
SER 191 0.15 TRP 110 -0.20 VAL 17
SER 191 0.14 GLN 111 -0.19 VAL 17
SER 191 0.14 GLN 112 -0.17 PRO 253
SER 191 0.15 GLU 113 -0.18 PRO 253
SER 191 0.15 GLU 114 -0.20 PRO 253
SER 191 0.15 PRO 115 -0.23 PRO 253
SER 191 0.11 SER 116 -0.28 ALA 8
SER 191 0.10 GLU 117 -0.43 ALA 8
SER 191 0.15 PHE 118 -0.31 PRO 253
SER 191 0.22 ASP 119 -0.27 PRO 253
SER 191 0.26 LEU 120 -0.36 ASP 12
SER 191 0.33 ALA 121 -0.37 ALA 184
SER 191 0.33 TYR 122 -0.29 PRO 253
SER 191 0.34 ALA 123 -0.29 GLY 16
SER 191 0.43 ASP 124 -0.37 ASP 180
PRO 190 0.49 PHE 125 -0.37 PRO 253
PRO 190 0.42 LEU 126 -0.26 PRO 253
CYS 188 0.45 ALA 127 -0.32 PRO 253
CYS 188 0.63 LEU 128 -0.43 PRO 253
CYS 188 0.50 ASP 129 -0.33 PRO 253
CYS 188 0.47 ILE 130 -0.27 LEU 39
CYS 188 0.47 SER 131 -0.30 PRO 253
LEU 189 0.46 MET 132 -0.32 PRO 253
LEU 189 0.38 LEU 133 -0.29 LEU 39
LEU 189 0.32 ARG 134 -0.25 LEU 48
LEU 189 0.32 LEU 135 -0.28 LEU 48
LEU 189 0.33 PHE 136 -0.33 LEU 48
LEU 189 0.26 GLU 137 -0.33 LEU 52
TRP 237 0.25 THR 138 -0.30 LEU 48
TRP 237 0.23 PHE 139 -0.37 LEU 48
TRP 237 0.30 LEU 140 -0.44 LEU 48
LEU 234 0.39 GLU 141 -0.34 LEU 48
PHE 233 0.36 THR 142 -0.29 ALA 45
PHE 233 0.41 ALA 143 -0.38 LEU 44
PHE 233 0.51 PRO 144 -0.48 LEU 44
ALA 230 0.42 GLN 145 -0.38 ALA 45
PHE 233 0.39 LEU 146 -0.41 LEU 44
ALA 230 0.38 THR 147 -0.52 LEU 44
ALA 230 0.40 LEU 148 -0.64 LEU 44
ALA 230 0.30 VAL 149 -0.53 LEU 44
GLY 40 0.31 LEU 150 -0.59 LEU 44
GLY 40 0.38 ALA 151 -0.76 LEU 44
GLY 40 0.49 ILE 152 -0.78 LEU 44
GLY 40 0.53 MET 153 -0.60 LEU 44
GLY 40 0.52 LEU 154 -0.62 LEU 44
GLY 40 0.65 GLN 155 -0.68 LEU 44
GLY 40 0.87 SER 156 -0.62 LEU 44
GLY 40 0.71 GLY 157 -0.49 ARG 42
GLY 40 0.49 ARG 158 -0.82 ARG 42
GLY 40 0.37 ALA 159 -0.64 ARG 42
LEU 39 0.33 GLU 160 -0.60 ARG 42
LEU 39 0.28 TYR 161 -0.43 ARG 42
LEU 39 0.22 TYR 162 -0.34 ARG 42
ALA 230 0.20 GLN 163 -0.44 ARG 42
LEU 172 0.23 TRP 164 -0.38 ARG 42
LEU 172 0.24 VAL 165 -0.28 ARG 42
PHE 233 0.29 GLY 166 -0.27 ARG 42
PHE 233 0.30 ILE 167 -0.31 ARG 42
LEU 172 0.28 CYS 168 -0.25 ARG 42
PHE 233 0.29 THR 169 -0.19 ARG 42
PHE 233 0.33 SER 170 -0.24 ARG 42
PHE 233 0.27 PHE 171 -0.26 LEU 44
CYS 168 0.28 LEU 172 -0.19 CYS 326
PHE 233 0.26 GLY 173 -0.20 ARG 42
PHE 233 0.24 ILE 174 -0.26 LEU 44
TYR 161 0.18 SER 175 -0.24 LEU 44
CYS 168 0.20 TRP 176 -0.26 ASP 124
LEU 189 0.20 ALA 177 -0.26 ASP 124
PRO 343 0.18 LEU 178 -0.32 PHE 251
TYR 161 0.17 LEU 179 -0.31 PRO 253
CYS 188 0.17 ASP 180 -0.37 ASP 124
LEU 189 0.25 TYR 181 -0.40 PRO 253
PRO 343 0.24 HIS 182 -0.41 PRO 253
PRO 193 0.17 ARG 183 -0.41 PRO 253
SER 131 0.29 ALA 184 -0.47 PRO 253
SER 131 0.31 LEU 185 -0.48 PRO 253
LYS 192 0.34 ARG 186 -0.40 PRO 253
LYS 192 0.32 THR 187 -0.41 PRO 253
LEU 128 0.63 CYS 188 -0.38 PRO 253
LEU 128 0.48 LEU 189 -0.21 PRO 253
PHE 125 0.49 PRO 190 -0.19 HIS 342
PHE 125 0.45 SER 191 -0.13 PRO 343
LEU 128 0.37 LYS 192 -0.16 PRO 253
ARG 186 0.33 PRO 193 -0.12 GLY 198
ARG 186 0.25 LEU 194 -0.18 PRO 253
ARG 186 0.16 LEU 195 -0.24 PRO 253
ILE 268 0.13 GLY 196 -0.30 PRO 253
TYR 161 0.12 LEU 197 -0.31 PRO 253
TRP 210 0.10 GLY 198 -0.28 PRO 253
ILE 268 0.11 SER 199 -0.31 PRO 253
TYR 161 0.13 SER 200 -0.34 PRO 253
TRP 210 0.13 VAL 201 -0.30 PRO 253
TRP 210 0.13 ILE 202 -0.29 PRO 253
SER 272 0.13 TYR 203 -0.33 PHE 251
SER 272 0.14 PHE 204 -0.31 PHE 251
TRP 210 0.15 LEU 205 -0.29 LEU 44
TRP 210 0.16 TRP 206 -0.32 LEU 44
TRP 210 0.15 ASN 207 -0.33 LEU 44
ILE 297 0.17 LEU 208 -0.36 LEU 44
ILE 297 0.21 LEU 209 -0.38 LEU 44
ILE 297 0.21 LEU 210 -0.40 LEU 44
ILE 297 0.19 LEU 211 -0.42 LEU 44
ILE 297 0.22 TRP 212 -0.46 LEU 44
ILE 297 0.27 PRO 213 -0.46 LEU 44
LEU 298 0.19 ARG 214 -0.49 LEU 44
ILE 167 0.22 VAL 215 -0.52 LEU 44
GLY 40 0.22 LEU 216 -0.54 LEU 44
GLY 40 0.23 ALA 217 -0.52 LEU 44
LEU 146 0.24 VAL 218 -0.59 LEU 44
GLY 40 0.26 ALA 219 -0.67 LEU 44
GLY 40 0.33 LEU 220 -0.61 LEU 44
GLY 40 0.30 PHE 221 -0.59 LEU 44
GLY 40 0.31 SER 222 -0.73 LEU 44
GLY 40 0.42 ALA 223 -0.75 LEU 44
GLY 40 0.40 LEU 224 -0.60 LEU 44
GLY 40 0.32 PHE 225 -0.59 LEU 44
GLY 40 0.28 PRO 226 -0.74 LEU 44
LEU 148 0.23 SER 227 -0.54 LEU 44
VAL 216 0.26 TYR 228 -0.47 LEU 44
THR 147 0.38 VAL 229 -0.53 LEU 44
GLN 145 0.42 ALA 230 -0.37 LEU 44
PRO 144 0.35 LEU 231 -0.27 LEU 44
PRO 144 0.37 HIS 232 -0.35 LEU 44
PRO 144 0.51 PHE 233 -0.37 LEU 44
PRO 144 0.45 LEU 234 -0.23 LEU 44
PRO 144 0.38 GLY 235 -0.24 PHE 212
PRO 144 0.33 LEU 236 -0.29 LEU 44
GLU 141 0.34 TRP 237 -0.29 LEU 44
GLU 141 0.31 LEU 238 -0.20 LEU 44
GLU 141 0.26 VAL 239 -0.22 LEU 44
GLU 141 0.22 LEU 240 -0.27 LEU 44
GLU 141 0.23 LEU 241 -0.22 LEU 44
THR 224 0.25 LEU 242 -0.19 LEU 44
PRO 343 0.21 TRP 243 -0.23 LEU 44
PRO 190 0.25 VAL 244 -0.23 LEU 44
PRO 190 0.23 TRP 245 -0.24 LYS 234
PRO 190 0.21 LEU 246 -0.29 LYS 234
PRO 190 0.23 GLN 247 -0.37 LYS 234
PRO 190 0.26 GLY 248 -0.41 PRO 255
PRO 190 0.22 THR 249 -0.42 ALA 277
ARG 83 0.21 ASP 250 -0.53 GLU 278
ARG 83 0.25 PHE 251 -0.42 ASN 275
ARG 83 0.29 MET 252 -0.36 ALA 184
ARG 83 0.32 PRO 253 -0.48 LEU 185
ARG 83 0.32 ASP 254 -0.38 GLU 278
ARG 83 0.28 PRO 255 -0.50 GLU 278
LEU 55 0.36 SER 256 -0.37 GLU 278
ALA 59 0.30 SER 257 -0.24 GLU 278
LEU 220 0.20 GLU 258 -0.26 GLU 278
LEU 220 0.27 TRP 259 -0.21 LEU 39
PRO 190 0.25 LEU 260 -0.25 LEU 39
PRO 190 0.31 TYR 261 -0.26 LEU 39
PRO 190 0.28 ARG 262 -0.23 LEU 39
LEU 189 0.27 VAL 263 -0.25 LEU 39
LEU 189 0.34 THR 264 -0.33 LEU 48
LEU 189 0.34 VAL 265 -0.31 LEU 44
LEU 189 0.28 ALA 266 -0.32 LEU 44
LEU 189 0.27 THR 267 -0.39 LEU 44
LEU 189 0.29 ILE 268 -0.39 LEU 44
PRO 343 0.26 LEU 269 -0.37 LEU 44
SER 170 0.23 TYR 270 -0.42 LEU 44
ILE 174 0.21 PHE 271 -0.46 LEU 44
PRO 343 0.23 SER 272 -0.40 LEU 44
PRO 343 0.30 TRP 273 -0.36 LEU 44
PRO 343 0.36 PHE 274 -0.37 PHE 251
PRO 343 0.39 ASN 275 -0.42 PHE 251
PRO 343 0.34 VAL 276 -0.38 ASP 250
PRO 190 0.31 ALA 277 -0.49 ASP 250
PRO 193 0.25 GLU 278 -0.53 ASP 250
PRO 193 0.21 GLY 279 -0.47 ASP 250
PRO 193 0.16 ARG 280 -0.37 PRO 255
PRO 343 0.17 THR 281 -0.35 ASP 250
LYS 234 0.12 ARG 282 -0.28 ASP 250
LYS 234 0.19 GLY 283 -0.25 LEU 44
PRO 343 0.19 ARG 284 -0.27 LEU 44
PRO 343 0.18 ALA 285 -0.30 LEU 44
ARG 233 0.16 ILE 286 -0.29 LEU 44
ARG 233 0.17 ILE 287 -0.28 LEU 44
PRO 343 0.16 HIS 288 -0.32 LEU 44
TRP 210 0.13 PHE 289 -0.35 LEU 44
TRP 210 0.17 ALA 290 -0.32 LEU 44
GLY 214 0.16 PHE 291 -0.33 LEU 44
GLY 214 0.16 LEU 292 -0.39 LEU 44
TRP 210 0.21 LEU 293 -0.39 LEU 44
TRP 210 0.28 SER 294 -0.34 LEU 44
GLY 214 0.23 ASP 295 -0.39 LEU 44
GLY 323 0.26 SER 296 -0.44 LEU 44
CYS 324 0.42 ILE 297 -0.39 LEU 44
TRP 210 0.31 LEU 298 -0.37 LEU 44
PRO 211 0.28 LEU 299 -0.46 LEU 44
GLY 323 0.31 VAL 300 -0.44 LEU 44
ALA 208 0.37 ALA 301 -0.37 LEU 44
ALA 208 0.32 THR 302 -0.41 LEU 44
GLY 40 0.35 TRP 303 -0.45 LEU 44
ALA 208 0.41 VAL 304 -0.39 LEU 44
ALA 208 0.50 THR 305 -0.35 LEU 44
GLY 40 0.39 HIS 306 -0.39 LEU 44
GLY 40 0.44 SER 307 -0.39 LEU 44
GLY 40 0.49 SER 308 -0.35 LEU 44
GLY 40 0.51 TRP 309 -0.40 LEU 44
GLY 40 0.59 LEU 310 -0.45 LEU 44
GLY 40 0.65 PRO 311 -0.45 LEU 44
GLY 40 0.56 SER 312 -0.40 LEU 44
GLY 40 0.54 GLY 313 -0.44 LEU 44
GLY 40 0.44 ILE 314 -0.44 LEU 44
GLY 40 0.40 PRO 315 -0.40 LEU 44
GLY 40 0.37 LEU 316 -0.44 LEU 44
GLY 40 0.35 GLN 317 -0.37 LEU 44
GLY 40 0.29 LEU 318 -0.37 LEU 44
GLY 40 0.27 TRP 319 -0.41 LEU 44
ALA 301 0.35 LEU 320 -0.42 LEU 44
ALA 301 0.37 PRO 321 -0.36 LEU 44
ALA 301 0.32 VAL 322 -0.38 LEU 44
ILE 297 0.39 GLY 323 -0.42 LEU 44
ILE 297 0.42 CYS 324 -0.38 LEU 44
ILE 297 0.34 GLY 325 -0.35 LEU 44
ILE 297 0.30 CYS 326 -0.38 LEU 44
ILE 297 0.28 PHE 327 -0.40 LEU 44
ALA 208 0.25 PHE 328 -0.35 LEU 44
ALA 208 0.22 LEU 329 -0.34 LEU 44
TRP 210 0.19 GLY 330 -0.35 LEU 44
ALA 208 0.17 LEU 331 -0.35 LEU 44
ALA 208 0.16 ALA 332 -0.32 LEU 44
ALA 208 0.14 LEU 333 -0.31 LEU 44
TRP 210 0.13 ARG 334 -0.31 LEU 44
ALA 208 0.11 LEU 335 -0.31 LEU 44
ALA 208 0.10 VAL 336 -0.28 LEU 44
TRP 210 0.11 TYR 337 -0.29 PRO 253
TRP 210 0.09 TYR 338 -0.29 PRO 253
ALA 208 0.08 HIS 339 -0.25 PRO 253
ALA 208 0.08 TRP 340 -0.23 PRO 253
PHE 274 0.11 LEU 341 -0.26 PRO 253
PHE 274 0.20 HIS 342 -0.28 PRO 253
ASN 275 0.39 PRO 343 -0.20 TRP 340

If you find results from this site helpful for your research, please cite one of our papers:

elNémo is maintained by Yves-Henri Sanejouand.
It was developed by Karsten Suhre.
Between 2003 and 2014, it was hosted by IGS (Marseille).
Between 2015 and 2025, it was hosted by US2B (Nantes).
Last modification: december 26th, 2025.