Should you encounter any unexpected behaviour,
please let us know.
elNémo has been hacked on november 27th.
It has been moved away and runs again.
Still some additional cleaning from time to time
Sorry for the inconvenience.

* *

CA distance fluctuations for 260408115242648516

--- normal mode 16 ---

This matrix displays the maximum distance fluctuations between all pairs of CA atoms and between the two extreme conformations that were computed for this mode (DQMIN/DQMAX). Distance increases are plotted in blue and decreases in red for the strongest 10% of the residue pair distance changes. Every pixel corresponds to a single residue. Grey lines are drawn every 10 residues, yellow lines every 100 residues (counting from the upper left corner).

The following table indicates for every residue the two corresponding residues with the strongest CA distance fluctuations.

[HELP on distance fluctuations]

GD ok

largest increase ref largest decrease
LYS 1488 0.18 THR 69 -0.33 GLU 1593

LYS 1488 0.20 ILE 70 -0.33 GLU 1593

LYS 1488 0.21 ALA 71 -0.30 GLU 1593

LYS 1488 0.24 PHE 72 -0.29 GLU 1593

LYS 1488 0.25 GLU 73 -0.27 GLU 1593

LYS 1488 0.24 PHE 74 -0.31 GLU 1593

LYS 1488 0.24 ASP 75 -0.29 GLU 1593

LYS 1488 0.25 GLY 76 -0.22 GLU 1593

LYS 1488 0.23 GLN 77 -0.23 GLU 1593

LYS 1488 0.22 GLN 78 -0.24 ASP 830

LYS 1488 0.21 VAL 79 -0.29 GLU 1593

LYS 1488 0.20 GLU 80 -0.32 GLU 1593

LYS 1488 0.19 ALA 81 -0.36 GLU 1593

LYS 1488 0.17 GLN 82 -0.39 GLU 1593

LYS 1488 0.17 PRO 83 -0.40 GLU 1593

LYS 1488 0.16 GLY 84 -0.44 GLU 1593

LYS 1488 0.17 GLU 85 -0.45 GLU 1593

LYS 1488 0.18 THR 86 -0.48 GLU 1593

LYS 1488 0.20 ILE 87 -0.45 GLU 1593

LYS 1488 0.18 TRP 88 -0.51 GLU 1593

LYS 1488 0.17 ALA 89 -0.50 GLU 1593

LYS 1488 0.18 VAL 90 -0.43 GLU 1593

LYS 1488 0.19 ALA 91 -0.44 GLU 1593

LYS 1488 0.16 LYS 92 -0.49 GLU 1593

LYS 1488 0.16 ARG 93 -0.44 GLU 1593

LYS 1488 0.17 LEU 94 -0.39 GLU 1593

LYS 1488 0.16 GLY 95 -0.43 GLU 1593

LYS 1488 0.17 THR 96 -0.44 GLU 1593

LYS 1488 0.16 HSD 97 -0.52 GLU 1593

LYS 1488 0.17 ILE 98 -0.56 GLU 1593

LYS 1488 0.15 PRO 99 -0.66 GLU 1593

LYS 1488 0.14 HSD 100 -0.71 GLU 1593

LYS 1488 0.13 LEU 101 -0.78 GLU 1593

LYS 1488 0.12 CYS 102 -0.75 GLU 1593

LYS 1488 0.12 HSD 103 -0.68 GLU 1593

LYS 1488 0.11 LYS 104 -0.67 GLU 1593

LYS 1488 0.11 PRO 105 -0.61 GLU 1593

LYS 1488 0.10 ASP 106 -0.60 GLU 1593

LYS 1488 0.10 PRO 107 -0.57 GLU 1593

LEU 461 0.10 GLY 108 -0.59 GLU 1593

LYS 1488 0.10 TYR 109 -0.62 GLU 1593

LYS 1488 0.11 ARG 110 -0.60 GLU 1593

LYS 1488 0.12 PRO 111 -0.61 GLU 1593

GLU 1487 0.13 ASP 112 -0.64 GLU 1593

GLU 1487 0.14 GLY 113 -0.64 GLU 1593

GLU 1487 0.14 ASN 114 -0.70 GLU 1593

GLY 1490 0.14 CYS 115 -0.77 GLU 1593

GLY 1490 0.16 ARG 116 -0.69 GLU 1593

GLY 1490 0.15 ALA 117 -0.71 GLU 1593

LYS 1488 0.17 CYS 118 -0.62 GLU 1593

LYS 1488 0.21 MET 119 -0.55 GLU 1593

LYS 1488 0.24 VAL 120 -0.46 GLU 1593

LYS 1488 0.29 GLU 121 -0.38 GLU 1593

LYS 1488 0.30 ILE 122 -0.34 GLU 1593

LYS 1488 0.34 GLU 123 -0.27 GLU 1593

LYS 1488 0.38 GLY 124 -0.25 GLU 1593

GLU 1487 0.35 GLU 125 -0.32 GLU 1593

GLU 1487 0.42 ARG 126 -0.34 ALA 1592

GLU 1487 0.33 VAL 127 -0.41 ALA 1592

LYS 1488 0.27 LEU 128 -0.45 GLU 1593

GLU 1487 0.23 ALA 129 -0.49 GLU 1593

LYS 1488 0.19 ALA 130 -0.55 GLU 1593

LYS 1488 0.19 SER 131 -0.52 GLU 1593

LYS 1488 0.16 CYS 132 -0.57 GLU 1593

GLU 1487 0.17 LYS 133 -0.55 GLU 1593

LYS 1488 0.20 ARG 134 -0.48 GLU 1593

LYS 1488 0.20 THR 135 -0.44 GLU 1593

LYS 1488 0.22 PRO 136 -0.38 GLU 1593

LYS 1488 0.23 ALA 137 -0.33 GLU 1593

LYS 1488 0.23 ILE 138 -0.29 GLU 1593

LYS 1488 0.26 GLY 139 -0.25 GLU 1593

LYS 1488 0.28 MET 140 -0.29 GLU 1593

LYS 1488 0.27 LYS 141 -0.28 GLU 1593

LYS 1488 0.26 VAL 142 -0.34 GLU 1593

LYS 1488 0.26 LYS 143 -0.34 GLU 1593

LYS 1488 0.23 SER 144 -0.41 GLU 1593

LYS 1488 0.21 ALA 145 -0.37 GLU 1593

LYS 1488 0.24 THR 146 -0.32 GLU 1593

TYR 1489 0.22 GLU 147 -0.33 GLU 1593

TYR 1489 0.25 ARG 148 -0.38 ALA 1592

LYS 1488 0.22 ALA 149 -0.47 GLU 1593

LYS 1488 0.18 THR 150 -0.51 GLU 1593

TYR 1489 0.17 LYS 151 -0.53 ALA 1592

GLY 1490 0.19 ALA 152 -0.59 ALA 1592

GLY 1490 0.16 ARG 153 -0.66 GLU 1593

GLY 1490 0.13 ALA 154 -0.72 GLU 1593

GLY 1490 0.13 MET 155 -0.78 ALA 1592

GLY 1490 0.14 VAL 156 -0.81 GLU 1593

GLY 1490 0.12 LEU 157 -0.90 GLU 1593

GLY 1490 0.11 GLU 158 -0.98 GLU 1593

GLY 1490 0.11 LEU 159 -1.01 ALA 1592

GLY 1490 0.10 LEU 160 -1.04 GLU 1593

GLY 1490 0.09 VAL 161 -1.16 GLU 1593

GLU 573 0.09 ALA 162 -1.28 GLU 1593

GLU 573 0.09 ASP 163 -1.26 GLU 1593

GLU 573 0.09 GLN 164 -1.26 GLU 1593

GLU 573 0.09 PRO 165 -1.31 GLU 1593

GLU 573 0.08 GLU 166 -1.35 GLU 1593

PRO 342 0.08 ARG 167 -1.18 GLU 1593

PRO 342 0.09 ALA 168 -1.11 GLU 1593

PRO 342 0.10 THR 169 -1.13 GLU 1593

PRO 342 0.09 SER 170 -1.12 GLU 1593

TYR 510 0.09 HSD 171 -1.02 GLU 1593

ALA 509 0.09 ASP 172 -0.97 GLU 1593

PRO 342 0.08 PRO 173 -1.00 GLU 1593

LYS 1488 0.09 SER 174 -0.89 GLU 1593

LYS 1488 0.09 SER 175 -0.90 GLU 1593

LYS 1488 0.10 HSD 176 -0.84 GLU 1593

LYS 1488 0.11 PHE 177 -0.91 GLU 1593

LYS 1488 0.10 TRP 178 -0.95 GLU 1593

LYS 1488 0.10 VAL 179 -0.83 GLU 1593

LYS 1488 0.11 GLN 180 -0.80 GLU 1593

LYS 1488 0.10 ALA 181 -0.89 GLU 1593

LYS 1488 0.10 ASP 182 -0.83 GLU 1593

LYS 1488 0.11 VAL 183 -0.71 GLU 1593

LYS 1488 0.12 LEU 184 -0.72 GLU 1593

LYS 1488 0.10 ASP 185 -0.76 GLU 1593

LYS 1488 0.09 VAL 186 -0.90 GLU 1593

LYS 1488 0.08 THR 187 -1.05 GLU 1593

GLU 573 0.07 GLU 188 -1.20 GLU 1593

GLU 573 0.08 SER 189 -1.23 ALA 1592

GLU 573 0.07 ARG 190 -1.32 ALA 1592

GLU 573 0.08 PHE 191 -1.36 ALA 1592

GLU 573 0.09 PRO 192 -1.48 ALA 1592

GLU 573 0.09 ALA 193 -1.36 GLU 1593

GLU 573 0.10 ALA 194 -1.21 GLU 1593

GLU 573 0.11 GLU 195 -1.20 GLU 1593

GLU 573 0.11 ARG 196 -1.10 GLU 1593

GLU 573 0.12 TRP 197 -1.02 GLU 1593

GLU 573 0.12 THR 198 -1.01 GLU 1593

THR 574 0.11 SER 199 -0.97 GLU 1593

THR 574 0.12 ASP 200 -0.88 GLU 1593

THR 574 0.11 VAL 201 -0.84 GLU 1593

THR 574 0.12 SER 202 -0.79 GLU 1593

ALA 509 0.12 HSD 203 -0.76 GLU 1593

ALA 509 0.11 PRO 204 -0.74 GLU 1593

VAL 891 0.14 ALA 205 -0.74 GLU 1593

ALA 509 0.12 MET 206 -0.79 GLU 1593

ALA 509 0.11 SER 207 -0.86 GLU 1593

TYR 510 0.12 VAL 208 -0.90 GLU 1593

THR 574 0.11 ASN 209 -0.99 GLU 1593

GLU 573 0.11 LEU 210 -1.00 GLU 1593

GLU 573 0.11 ASP 211 -1.11 GLU 1593

GLU 573 0.10 ALA 212 -1.09 GLU 1593

GLU 577 0.11 CYS 213 -1.00 GLU 1593

GLY 1490 0.11 ILE 214 -0.96 GLU 1593

GLU 577 0.12 GLN 215 -0.87 GLU 1593

GLY 1490 0.11 CYS 216 -0.81 GLU 1593

GLU 577 0.12 ASN 217 -0.76 GLU 1593

TYR 510 0.11 LEU 218 -0.75 GLU 1593

TYR 510 0.13 CYS 219 -0.76 GLU 1593

TYR 510 0.15 VAL 220 -0.72 GLU 1593

TYR 510 0.12 ARG 221 -0.67 GLU 1593

TYR 510 0.11 ALA 222 -0.68 GLU 1593

ALA 509 0.14 CYS 223 -0.67 GLU 1593

TYR 510 0.17 ARG 224 -0.64 GLU 1593

ALA 493 0.16 GLU 225 -0.61 GLU 1593

ALA 493 0.12 VAL 226 -0.61 GLU 1593

ALA 509 0.13 GLN 227 -0.61 GLU 1593

ALA 509 0.18 VAL 228 -0.60 GLU 1593

ALA 509 0.21 ASN 229 -0.63 GLU 1593

ALA 509 0.23 ASP 230 -0.64 GLU 1593

ALA 509 0.19 VAL 231 -0.68 GLU 1593

TYR 510 0.17 ILE 232 -0.72 GLU 1593

TYR 510 0.17 GLY 233 -0.73 GLU 1593

GLU 577 0.15 MET 234 -0.76 GLU 1593

GLU 577 0.17 ALA 235 -0.75 GLU 1593

GLU 573 0.16 TYR 236 -0.77 GLU 1593

GLU 577 0.15 ARG 237 -0.76 GLU 1593

GLU 577 0.13 ALA 238 -0.80 GLU 1593

GLU 573 0.13 ALA 239 -0.90 GLU 1593

GLU 573 0.14 GLY 240 -0.89 GLU 1593

GLU 577 0.14 SER 241 -0.84 GLU 1593

GLU 573 0.14 LYS 242 -0.87 GLU 1593

TYR 510 0.14 VAL 243 -0.84 GLU 1593

TYR 510 0.16 VAL 244 -0.79 GLU 1593

TYR 510 0.17 PHE 245 -0.75 GLU 1593

TYR 510 0.20 ASP 246 -0.70 GLU 1593

THR 574 0.19 PHE 247 -0.71 GLU 1593

THR 574 0.17 ASP 248 -0.77 GLU 1593

THR 574 0.17 ASP 249 -0.75 GLU 1593

THR 574 0.15 PRO 250 -0.78 GLU 1593

ALA 509 0.14 MET 251 -0.77 GLU 1593

THR 574 0.13 GLY 252 -0.73 GLU 1593

THR 574 0.15 GLY 253 -0.70 GLU 1593

THR 574 0.16 SER 254 -0.70 GLU 1593

THR 504 0.19 THR 255 -0.66 GLU 1593

ALA 509 0.17 CYS 256 -0.69 GLU 1593

ALA 509 0.16 VAL 257 -0.66 GLU 1593

ALA 509 0.14 ALA 258 -0.69 GLU 1593

ALA 509 0.14 CYS 259 -0.66 GLU 1593

ALA 509 0.12 GLY 260 -0.71 GLU 1593

ALA 509 0.12 GLU 261 -0.70 GLU 1593

ALA 509 0.13 CYS 262 -0.75 GLU 1593

ALA 509 0.11 VAL 263 -0.78 GLU 1593

ALA 509 0.10 GLN 264 -0.74 GLU 1593

ALA 509 0.10 ALA 265 -0.75 GLU 1593

TYR 510 0.10 CYS 266 -0.82 GLU 1593

LYS 1488 0.10 PRO 267 -0.85 GLU 1593

GLY 1490 0.10 THR 268 -0.94 GLU 1593

TYR 510 0.10 GLY 269 -0.94 GLU 1593

TYR 510 0.11 ALA 270 -0.96 GLU 1593

ALA 509 0.11 LEU 271 -0.88 GLU 1593

ALA 509 0.11 MET 272 -0.85 GLU 1593

ALA 509 0.11 PRO 273 -0.80 GLU 1593

HSD 341 0.11 ALA 274 -0.81 GLU 1593

HSD 341 0.13 ALA 275 -0.77 GLU 1593

PRO 342 0.10 TYR 276 -0.81 GLU 1593

PRO 342 0.12 LEU 277 -0.88 GLU 1593

PRO 342 0.13 ASP 278 -0.88 GLU 1593

PRO 342 0.13 ALA 279 -0.89 GLU 1593

PRO 342 0.11 ASN 280 -0.99 GLU 1593

PRO 342 0.11 GLN 281 -0.99 GLU 1593

PRO 342 0.10 THR 282 -1.00 GLU 1593

PRO 342 0.10 ARG 283 -0.93 GLU 1593

PRO 342 0.09 THR 284 -0.87 GLU 1593

PRO 342 0.09 VAL 285 -0.79 GLU 1593

LYS 1488 0.08 TYR 286 -0.75 GLU 1593

LYS 1488 0.08 PRO 287 -0.69 GLU 1593

LYS 1488 0.08 ASP 288 -0.63 GLU 1593

LYS 1488 0.08 ARG 289 -0.61 GLU 1593

LYS 1488 0.08 GLU 290 -0.61 GLU 1593

LYS 1488 0.08 VAL 291 -0.57 GLU 1593

LYS 1488 0.07 LYS 292 -0.56 GLU 1593

LYS 1488 0.07 SER 293 -0.55 GLU 1593

LYS 1488 0.07 LEU 294 -0.55 GLU 1593

LYS 1488 0.07 CYS 295 -0.56 GLU 1593

LYS 1488 0.06 PRO 296 -0.54 GLU 1593

LYS 1488 0.06 TYR 297 -0.54 GLU 1593

LYS 1488 0.06 CYS 298 -0.53 GLU 1593

LYS 1488 0.06 GLY 299 -0.51 GLU 1593

LYS 1488 0.06 VAL 300 -0.53 GLU 1593

LYS 1488 0.06 GLY 301 -0.53 GLU 1593

LYS 1488 0.07 CYS 302 -0.56 GLU 1593

LYS 1488 0.07 GLN 303 -0.56 GLU 1593

LYS 1488 0.07 VAL 304 -0.59 GLU 1593

LYS 1488 0.08 SER 305 -0.61 GLU 1593

LYS 1488 0.08 TYR 306 -0.62 GLU 1593

LYS 1488 0.08 LYS 307 -0.65 GLU 1593

VAL 765 0.08 VAL 308 -0.62 GLU 1593

PRO 768 0.08 LYS 309 -0.64 GLU 1593

PRO 768 0.10 ASP 310 -0.60 GLU 1593

ALA 766 0.11 GLU 311 -0.57 GLU 1593

PRO 768 0.12 ARG 312 -0.60 GLU 1593

PRO 768 0.09 ILE 313 -0.62 GLU 1593

PRO 768 0.08 VAL 314 -0.67 GLU 1593

ALA 509 0.08 TYR 315 -0.68 GLU 1593

ALA 509 0.08 ALA 316 -0.66 GLU 1593

ALA 509 0.08 GLU 317 -0.66 GLU 1593

ALA 509 0.08 GLY 318 -0.63 GLU 1593

LYS 1488 0.08 VAL 319 -0.60 GLU 1593

LYS 1488 0.08 ASN 320 -0.57 GLU 1593

LYS 1488 0.07 GLY 321 -0.54 GLU 1593

LYS 1488 0.07 PRO 322 -0.52 GLU 1593

LYS 1488 0.06 ALA 323 -0.53 GLU 1593

GLY 623 0.08 ASN 324 -0.56 GLU 1593

LYS 1488 0.08 GLN 325 -0.57 GLU 1593

LYS 1488 0.08 ASN 326 -0.61 GLU 1593

ALA 509 0.09 ARG 327 -0.61 GLU 1593

ALA 509 0.09 LEU 328 -0.62 GLU 1593

ALA 509 0.11 CYS 329 -0.62 GLU 1593

ALA 509 0.11 VAL 330 -0.64 GLU 1593

ALA 509 0.09 LYS 331 -0.60 GLU 1593

ALA 509 0.08 GLY 332 -0.61 GLU 1593

ALA 509 0.10 ARG 333 -0.65 GLU 1593

ALA 509 0.10 PHE 334 -0.65 GLU 1593

ALA 509 0.09 GLY 335 -0.61 GLU 1593

ALA 509 0.07 PHE 336 -0.60 GLU 1593

HSD 341 0.10 ASP 337 -0.60 GLU 1593

ALA 275 0.07 TYR 338 -0.56 GLU 1593

LYS 1488 0.07 VAL 339 -0.55 GLU 1593

ARG 344 0.11 HSD 340 -0.56 GLU 1593

ALA 275 0.13 HSD 341 -0.54 GLU 1593

ASP 278 0.13 PRO 342 -0.51 GLU 1593

ALA 279 0.11 HSD 343 -0.49 GLU 1593

HSD 340 0.11 ARG 344 -0.49 GLU 1593

ASP 278 0.09 LEU 345 -0.46 GLU 1593

ASP 278 0.10 THR 346 -0.44 GLU 1593

ASP 278 0.09 VAL 347 -0.42 GLU 1593

ALA 279 0.08 PRO 348 -0.40 GLU 1593

ALA 279 0.09 LEU 349 -0.40 GLU 1593

ALA 279 0.08 ILE 350 -0.38 GLU 1593

ALA 279 0.08 ARG 351 -0.38 GLU 1593

ALA 279 0.08 LEU 352 -0.36 GLU 1593

ALA 279 0.08 GLU 353 -0.35 GLU 1593

MET 1022 0.09 ASN 354 -0.35 GLU 1593

MET 1022 0.09 VAL 355 -0.37 GLU 1593

MET 1022 0.11 PRO 356 -0.37 GLU 1593

MET 1022 0.09 LYS 357 -0.38 GLU 1593

MET 1022 0.11 ASP 358 -0.39 GLU 1593

THR 1028 0.12 ALA 359 -0.40 GLU 1593

THR 1028 0.17 ASN 360 -0.41 GLU 1593

THR 1028 0.10 ASP 361 -0.41 GLU 1593

ALA 987 0.09 GLN 362 -0.43 GLU 1593

ALA 1033 0.09 VAL 363 -0.43 GLU 1593

ALA 1033 0.13 ASP 364 -0.45 GLU 1593

ALA 1033 0.12 PRO 365 -0.46 GLU 1593

ALA 279 0.13 ALA 366 -0.46 GLU 1593

ALA 279 0.12 ASN 367 -0.43 GLU 1593

ALA 279 0.10 PRO 368 -0.42 GLU 1593

ALA 279 0.10 TRP 369 -0.40 GLU 1593

ALA 279 0.10 THR 370 -0.39 GLU 1593

ALA 279 0.09 HSD 371 -0.39 GLU 1593

ALA 279 0.09 PHE 372 -0.39 GLU 1593

ALA 279 0.10 ARG 373 -0.38 GLU 1593

ALA 279 0.10 GLU 374 -0.38 GLU 1593

ALA 279 0.09 ALA 375 -0.37 GLU 1593

ALA 279 0.08 THR 376 -0.37 GLU 1593

ASP 278 0.08 TRP 377 -0.37 GLU 1593

ALA 279 0.07 GLU 378 -0.35 GLU 1593

ALA 279 0.07 GLU 379 -0.35 GLU 1593

ALA 279 0.07 ALA 380 -0.37 GLU 1593

ALA 279 0.07 LEU 381 -0.37 GLU 1593

ALA 279 0.07 ASP 382 -0.35 GLU 1593

ALA 279 0.07 ARG 383 -0.35 GLU 1593

ALA 279 0.07 ALA 384 -0.37 GLU 1593

ALA 279 0.06 ALA 385 -0.35 GLU 1593

ALA 279 0.06 GLY 386 -0.34 GLU 1593

MET 1022 0.07 GLY 387 -0.35 GLU 1593

MET 1022 0.07 LEU 388 -0.35 GLU 1593

MET 1022 0.07 LYS 389 -0.34 GLU 1593

MET 1022 0.08 ALA 390 -0.33 GLU 1593

MET 1022 0.08 ILE 391 -0.34 GLU 1593

MET 1022 0.07 ARG 392 -0.34 GLU 1593

MET 1022 0.07 ASP 393 -0.32 GLU 1593

MET 1022 0.08 THR 394 -0.32 GLU 1593

MET 1022 0.08 ASN 395 -0.33 GLU 1593

MET 1022 0.07 GLY 396 -0.33 GLU 1593

GLU 1024 0.07 ARG 397 -0.34 GLU 1593

GLU 1024 0.07 LYS 398 -0.35 GLU 1593

GLU 1024 0.08 ALA 399 -0.35 GLU 1593

GLU 1024 0.07 LEU 400 -0.36 GLU 1593

GLU 1024 0.06 ALA 401 -0.38 GLU 1593

GLU 1024 0.05 GLY 402 -0.40 GLU 1593

PRO 701 0.05 PHE 403 -0.42 GLU 1593

LYS 1488 0.05 GLY 404 -0.43 GLU 1593

LYS 1488 0.05 SER 405 -0.45 GLU 1593

LYS 1488 0.05 ALA 406 -0.46 GLU 1593

LYS 1488 0.06 LYS 407 -0.48 GLU 1593

LYS 1488 0.06 GLY 408 -0.47 GLU 1593

LYS 1488 0.05 SER 409 -0.46 GLU 1593

GLY 749 0.07 ASN 410 -0.44 GLU 1593

GLY 749 0.07 GLU 411 -0.43 GLU 1593

LYS 1488 0.05 GLU 412 -0.43 GLU 1593

LYS 1488 0.05 ALA 413 -0.42 GLU 1593

GLY 749 0.05 TYR 414 -0.41 GLU 1593

GLU 412 0.05 LEU 415 -0.40 GLU 1593

LYS 1488 0.05 PHE 416 -0.40 GLU 1593

GLU 1024 0.04 GLN 417 -0.39 GLU 1593

GLU 1024 0.04 LYS 418 -0.38 GLU 1593

GLU 1024 0.05 LEU 419 -0.37 GLU 1593

GLU 1024 0.05 VAL 420 -0.37 GLU 1593

GLU 1024 0.05 ARG 421 -0.39 GLU 845

GLU 1024 0.05 LEU 422 -0.38 GLU 845

GLU 1024 0.06 GLY 423 -0.35 GLU 1593

GLU 1024 0.06 PHE 424 -0.35 GLU 1593

GLU 1024 0.06 GLY 425 -0.38 GLU 845

GLU 1024 0.06 THR 426 -0.39 GLU 845

GLU 1024 0.06 ASN 427 -0.41 GLU 845

GLU 1024 0.06 ASN 428 -0.38 GLU 1593

GLU 1024 0.05 VAL 429 -0.40 GLU 1593

VAL 679 0.05 ASP 430 -0.41 GLU 1593

ASP 705 0.05 HSD 431 -0.43 GLU 1593

LYS 1488 0.05 CYS 432 -0.45 GLU 1593

SER 807 0.06 THR 433 -0.45 GLU 1593

SER 807 0.06 ARG 434 -0.43 GLU 1593

ILE 968 0.06 LEU 435 -0.44 GLU 1593

ILE 968 0.08 CYS 436 -0.46 GLU 1593

PRO 825 0.08 HSD 437 -0.44 GLU 1593

GLY 966 0.16 ALA 438 -0.43 GLU 1593

PRO 825 0.06 SER 439 -0.41 GLU 1593

LYS 1488 0.05 SER 440 -0.42 GLU 1593

PRO 825 0.07 VAL 441 -0.42 GLU 1593

PRO 825 0.06 ALA 442 -0.40 GLU 1593

THR 603 0.09 ALA 443 -0.39 GLU 1593

GLU 1060 0.06 LEU 444 -0.40 GLU 1593

THR 1065 0.06 MET 445 -0.56 SER 653

THR 1065 0.08 GLU 446 -0.55 SER 653

THR 1065 0.09 GLY 447 -0.50 SER 653

THR 1065 0.08 LEU 448 -0.53 SER 653

THR 1065 0.07 ASN 449 -0.70 SER 653

GLY 1484 0.06 SER 450 -0.62 TYR 651

PRO 825 0.06 GLY 451 -0.42 GLU 1593

PRO 825 0.08 ALA 452 -0.43 GLU 1593

LYS 1488 0.06 VAL 453 -0.43 GLU 1593

LYS 1488 0.06 THR 454 -0.42 GLU 1593

TYR 839 0.07 ALA 455 -0.44 GLU 1593

LYS 1488 0.07 PRO 456 -0.46 GLU 1593

LYS 1488 0.07 PHE 457 -0.48 GLU 1593

ASN 324 0.08 SER 458 -0.48 GLU 1593

GLY 623 0.12 ALA 459 -0.45 GLU 1593

GLY 623 0.14 ALA 460 -0.46 GLU 1593

GLU 225 0.10 LEU 461 -0.46 GLU 1593

PRO 1374 0.11 ASP 462 -0.43 GLU 1593

ALA 487 0.12 ALA 463 -0.42 GLU 1593

GLY 492 0.20 GLU 464 -0.40 GLU 1593

SER 1100 0.18 VAL 465 -0.41 GLU 1593

SER 1100 0.14 ILE 466 -0.43 GLU 1593

SER 1100 0.14 VAL 467 -0.43 GLU 1593

SER 1100 0.10 VAL 468 -0.45 GLU 1593

LEU 609 0.09 ILE 469 -0.45 GLU 1593

LYS 1056 0.07 GLY 470 -0.46 GLU 1593

LYS 1488 0.06 ALA 471 -0.48 GLU 1593

LEU 877 0.07 ASN 472 -0.50 GLU 1593

ALA 509 0.07 PRO 473 -0.52 GLU 1593

VAL 257 0.10 THR 474 -0.55 GLU 1593

LEU 877 0.16 VAL 475 -0.55 GLU 1593

LYS 1488 0.06 ASN 476 -0.53 GLU 1593

ALA 509 0.06 HSD 477 -0.54 GLU 1593

ALA 509 0.08 PRO 478 -0.56 GLU 1593

ALA 509 0.07 VAL 479 -0.56 GLU 1593

GLY 623 0.07 ALA 480 -0.53 GLU 1593

ALA 509 0.09 ALA 481 -0.53 GLU 1593

ALA 509 0.09 THR 482 -0.56 GLU 1593

GLY 623 0.10 PHE 483 -0.53 GLU 1593

ILE 466 0.11 LEU 484 -0.51 GLU 1593

ALA 493 0.13 LYS 485 -0.53 GLU 1593

GLU 225 0.13 ASN 486 -0.52 GLU 1593

GLU 464 0.14 ALA 487 -0.49 GLU 1593

ALA 493 0.30 VAL 488 -0.49 GLU 1593

ALA 493 0.17 LYS 489 -0.50 GLU 1593

GLU 225 0.14 GLN 490 -0.49 GLU 1593

LYS 586 0.15 ARG 491 -0.46 GLU 1593

ALA 585 0.21 GLY 492 -0.45 GLU 1593

VAL 488 0.30 ALA 493 -0.43 GLU 1593

SER 1100 0.23 LYS 494 -0.42 GLU 1593

SER 1100 0.20 LEU 495 -0.44 GLU 1593

SER 1100 0.21 ILE 496 -0.43 GLU 1593

SER 1100 0.15 ILE 497 -0.45 GLU 1593

ASP 1097 0.14 MET 498 -0.44 GLU 1593

VAL 1051 0.10 ASP 499 -0.45 GLU 1593

ASP 937 0.18 PRO 500 -0.45 GLU 1593

ASP 937 0.15 ARG 501 -0.48 GLU 1593

ALA 514 0.19 ARG 502 -0.49 GLU 1593

THR 255 0.14 GLN 503 -0.51 GLU 1593

THR 255 0.19 THR 504 -0.54 GLU 1593

ALA 509 0.17 LEU 505 -0.52 GLU 1593

HSD 512 0.24 SER 506 -0.50 GLU 1593

ALA 509 0.23 ARG 507 -0.51 GLU 1593

ALA 509 0.39 HSD 508 -0.50 GLU 1593

HSD 508 0.39 ALA 509 -0.45 GLU 1593

SER 1100 0.40 TYR 510 -0.42 GLU 1593

SER 1100 0.36 ARG 511 -0.42 GLU 1593

ASP 1097 0.26 HSD 512 -0.43 GLU 1593

ASP 1097 0.23 LEU 513 -0.42 GLU 1593

ASP 937 0.27 ALA 514 -0.42 GLU 1593

PRO 939 0.22 PHE 515 -0.41 GLU 1593

PRO 939 0.28 ARG 516 -0.41 GLU 1593

PRO 939 0.17 PRO 517 -0.42 GLU 1593

PRO 939 0.12 GLY 518 -0.41 GLU 1593

PRO 939 0.15 SER 519 -0.40 GLU 1593

VAL 1057 0.13 ASP 520 -0.40 GLU 1593

GLU 1060 0.13 VAL 521 -0.38 GLU 1593

VAL 1057 0.17 ALA 522 -0.37 GLU 1593

GLU 1060 0.18 MET 523 -0.38 GLU 1593

GLU 1098 0.17 LEU 524 -0.38 GLU 1593

THR 1065 0.19 ASN 525 -0.36 GLU 1593

THR 1065 0.23 ALA 526 -0.34 GLU 1593

THR 1065 0.23 MET 527 -0.35 GLU 1593

THR 1065 0.22 LEU 528 -0.34 GLU 1593

THR 1065 0.25 ASN 529 -0.33 GLU 1593

THR 1065 0.28 VAL 530 -0.32 GLU 1593

PRO 1067 0.26 ILE 531 -0.32 GLU 1593

THR 1065 0.24 VAL 532 -0.31 GLU 1593

THR 1065 0.28 THR 533 -0.30 GLU 1593

THR 1065 0.30 GLU 534 -0.29 GLU 1593

PRO 1067 0.27 GLY 535 -0.29 LYS 656

PRO 1067 0.27 LEU 536 -0.30 GLU 1593

PRO 1067 0.24 TYR 537 -0.32 LYS 656

PRO 1266 0.22 ASP 538 -0.34 LYS 656

PRO 1266 0.22 GLU 539 -0.36 LYS 656

PRO 1266 0.22 GLN 540 -0.37 LYS 656

PRO 1266 0.18 TYR 541 -0.38 LYS 656

PRO 1266 0.18 ILE 542 -0.41 LYS 656

PRO 1266 0.19 ALA 543 -0.43 LYS 656

PRO 1266 0.17 GLY 544 -0.45 LYS 656

PRO 1266 0.14 TYR 545 -0.47 LYS 656

THR 1065 0.15 THR 546 -0.49 LYS 656

THR 1065 0.15 GLU 547 -0.53 LYS 656

THR 1065 0.16 ASN 548 -0.50 LYS 656

THR 1065 0.18 PHE 549 -0.44 LYS 656

THR 1065 0.19 GLU 550 -0.42 LYS 656

THR 1065 0.18 ALA 551 -0.42 LYS 656

THR 1065 0.19 LEU 552 -0.38 LYS 656

THR 1065 0.22 ARG 553 -0.36 LYS 656

THR 1065 0.21 GLU 554 -0.35 LYS 656

THR 1065 0.20 LYS 555 -0.34 GLU 655

THR 1065 0.22 ILE 556 -0.32 GLU 1593

THR 1065 0.24 VAL 557 -0.31 GLU 1593

THR 1065 0.23 ASP 558 -0.32 GLU 1593

THR 1065 0.23 PHE 559 -0.33 GLU 1593

THR 1065 0.28 THR 560 -0.32 GLU 1593

THR 1065 0.30 PRO 561 -0.33 GLU 1593

THR 1065 0.32 GLU 562 -0.32 GLU 1593

GLU 1061 0.27 LYS 563 -0.32 GLU 1593

VAL 1057 0.25 MET 564 -0.34 GLU 1593

VAL 1057 0.28 ALA 565 -0.35 GLU 1593

VAL 1057 0.27 SER 566 -0.35 GLU 1593

VAL 1057 0.22 VAL 567 -0.36 GLU 1593

PRO 939 0.22 CYS 568 -0.38 GLU 1593

PRO 939 0.29 GLY 569 -0.37 GLU 1593

VAL 1057 0.29 ILE 570 -0.37 GLU 1593

GLU 1060 0.36 ASP 571 -0.35 GLU 1593

GLU 1060 0.35 ALA 572 -0.33 GLU 1593

THR 1065 0.41 GLU 573 -0.33 GLU 1593

GLU 1098 0.37 THR 574 -0.35 GLU 1593

GLU 1098 0.30 LEU 575 -0.35 GLU 1593

THR 1065 0.33 ARG 576 -0.33 GLU 1593

ARG 1068 0.36 GLU 577 -0.34 GLU 1593

SER 1100 0.30 VAL 578 -0.36 GLU 1593

ARG 1068 0.26 ALA 579 -0.35 GLU 1593

PRO 1067 0.30 ARG 580 -0.33 GLU 1593

GLN 1069 0.28 LEU 581 -0.35 GLU 1593

SER 1100 0.22 TYR 582 -0.37 GLU 1593

ARG 1068 0.22 ALA 583 -0.35 GLU 1593

GLN 1069 0.25 ARG 584 -0.34 GLU 1593

ASN 1383 0.23 ALA 585 -0.35 GLU 1593

ASN 1383 0.20 LYS 586 -0.35 GLU 1593

GLY 492 0.15 SER 587 -0.38 GLU 1593

SER 1100 0.15 SER 588 -0.39 GLU 1593

GLN 618 0.11 LEU 589 -0.42 GLU 1593

SER 1100 0.10 ILE 590 -0.43 GLU 1593

LYS 1488 0.07 PHE 591 -0.45 GLU 1593

LYS 1488 0.06 TRP 592 -0.45 GLU 1593

LYS 1488 0.06 GLY 593 -0.46 GLU 1593

LYS 1488 0.05 MET 594 -0.46 GLU 1593

LYS 1488 0.06 GLY 595 -0.45 GLU 1593

VAL 1057 0.07 VAL 596 -0.43 GLU 1593

LYS 1488 0.05 SER 597 -0.43 GLU 1593

PRO 825 0.05 GLN 598 -0.44 GLU 1593

ASP 860 0.05 HSD 599 -0.42 GLU 1593

ASP 860 0.10 VAL 600 -0.40 GLU 1593

ASP 860 0.09 HSD 601 -0.40 GLU 1593

VAL 1057 0.06 GLY 602 -0.41 GLU 1593

ALA 443 0.09 THR 603 -0.40 GLU 1593

VAL 1057 0.08 ASP 604 -0.39 GLU 1593

VAL 1057 0.10 ASN 605 -0.40 GLU 1593

GLU 1060 0.09 SER 606 -0.40 GLU 1593

GLU 1060 0.10 ARG 607 -0.38 GLU 1593

GLU 1060 0.12 CYS 608 -0.38 GLU 1593

GLU 1098 0.12 LEU 609 -0.39 GLU 1593

GLU 1098 0.11 ILE 610 -0.38 GLU 1593

THR 1065 0.13 ALA 611 -0.36 GLU 1593

GLU 1098 0.15 LEU 612 -0.37 GLU 1593

SER 1100 0.14 ALA 613 -0.37 GLU 1593

PRO 1067 0.14 LEU 614 -0.36 LYS 656

PRO 1067 0.17 ILE 615 -0.34 LYS 656

PRO 1067 0.18 THR 616 -0.34 GLU 1593

PRO 1067 0.15 GLY 617 -0.34 GLU 1593

SER 1100 0.15 GLN 618 -0.36 GLU 1593

SER 1100 0.11 ILE 619 -0.38 GLU 1593

PRO 1374 0.10 GLY 620 -0.38 GLU 1593

PRO 1374 0.11 ARG 621 -0.38 GLU 1593

PRO 1374 0.10 PRO 622 -0.40 GLU 1593

ALA 460 0.14 GLY 623 -0.41 GLU 1593

ALA 460 0.10 THR 624 -0.40 GLU 1593

SER 1100 0.09 GLY 625 -0.40 GLU 1593

SER 1100 0.08 LEU 626 -0.42 GLU 1593

LYS 1488 0.07 HSD 627 -0.44 GLU 1593

LYS 1488 0.06 PRO 628 -0.45 GLU 1593

LYS 1488 0.05 LEU 629 -0.48 GLU 1593

LYS 1488 0.05 ARG 630 -0.48 GLU 1593

LYS 1488 0.05 GLY 631 -0.49 GLU 1593

LYS 1488 0.05 GLN 632 -0.50 GLU 1593

LYS 1488 0.05 ASN 633 -0.51 GLU 1593

LYS 1488 0.05 ASN 634 -0.48 GLU 1593

CYS 436 0.06 VAL 635 -0.47 GLU 1593

CYS 436 0.06 GLN 636 -0.46 GLU 1593

SER 807 0.05 GLY 637 -0.45 GLU 1593

THR 433 0.05 ALA 638 -0.44 GLU 1593

SER 807 0.06 SER 639 -0.43 GLU 1593

SER 807 0.08 ASP 640 -0.43 GLU 1593

SER 807 0.05 ALA 641 -0.42 GLU 1593

MET 805 0.05 GLY 642 -0.41 GLU 1593

SER 807 0.04 LEU 643 -0.41 GLU 1593

THR 678 0.05 ILE 644 -0.41 GLU 1593

LEU 677 0.08 PRO 645 -0.39 GLU 1593

LEU 677 0.08 MET 646 -0.52 MET 445

LEU 677 0.05 VAL 647 -0.54 ASN 449

LEU 677 0.04 TYR 648 -0.49 THR 844

MET 805 0.05 PRO 649 -0.44 PRO 843

PRO 806 0.08 ASP 650 -0.50 PRO 843

PRO 806 0.05 TYR 651 -0.62 SER 450

LEU 677 0.04 GLN 652 -0.69 THR 844

LEU 677 0.05 SER 653 -0.73 THR 844

LEU 677 0.04 VAL 654 -0.65 GLU 845

LEU 677 0.04 GLU 655 -0.72 GLU 845

GLU 1024 0.04 LYS 656 -0.90 GLU 845

GLU 1024 0.04 ASP 657 -0.80 GLU 845

GLU 1024 0.04 ALA 658 -0.84 GLU 845

GLU 1024 0.04 VAL 659 -0.78 GLU 845

GLU 1024 0.04 ARG 660 -0.67 GLU 845

GLU 1024 0.04 GLU 661 -0.64 GLU 845

GLU 1024 0.04 LEU 662 -0.61 GLU 845

GLU 1024 0.04 PHE 663 -0.55 GLU 845

LEU 787 0.05 GLU 664 -0.53 GLU 845

ASP 788 0.05 GLU 665 -0.50 GLU 845

TRP 789 0.04 PHE 666 -0.46 GLU 845

TRP 789 0.06 TRP 667 -0.43 GLU 845

ASP 788 0.09 GLY 668 -0.43 GLU 845

LEU 787 0.08 GLN 669 -0.44 GLU 845

ASP 786 0.06 SER 670 -0.48 GLU 845

GLU 1024 0.05 LEU 671 -0.50 GLU 845

GLY 425 0.06 ASP 672 -0.49 GLU 845

GLU 1024 0.05 PRO 673 -0.57 GLU 845

GLU 1024 0.05 GLN 674 -0.51 GLU 845

GLU 1024 0.05 LYS 675 -0.48 GLU 446

GLU 1024 0.05 GLY 676 -0.40 GLU 446

PRO 645 0.08 LEU 677 -0.38 GLU 1593

PRO 645 0.08 THR 678 -0.40 GLU 1593

PRO 645 0.05 VAL 679 -0.41 GLU 1593

ARG 925 0.06 VAL 680 -0.41 GLU 1593

GLU 1024 0.06 GLU 681 -0.39 GLU 1593

GLU 1024 0.07 ILE 682 -0.39 GLU 1593

GLU 1024 0.07 MET 683 -0.40 GLU 1593

ARG 925 0.08 ARG 684 -0.38 GLU 1593

GLU 1024 0.08 ALA 685 -0.37 GLU 1593

GLU 1024 0.09 ILE 686 -0.38 GLU 1593

GLU 1024 0.10 HSD 687 -0.37 GLU 1593

GLU 1024 0.10 ALA 688 -0.36 GLU 1593

GLU 1024 0.10 GLY 689 -0.35 GLU 1593

GLU 1024 0.09 GLU 690 -0.35 GLU 1593

GLU 1024 0.08 ILE 691 -0.36 GLU 1593

GLU 1024 0.09 ARG 692 -0.36 GLU 1593

GLU 1024 0.07 GLY 693 -0.37 GLU 1593

GLU 1024 0.06 MET 694 -0.39 GLU 1593

ALA 279 0.05 PHE 695 -0.40 GLU 1593

ALA 279 0.05 VAL 696 -0.42 GLU 1593

LYS 1488 0.05 GLU 697 -0.43 GLU 1593

LYS 1488 0.06 GLY 698 -0.45 GLU 1593

LYS 1488 0.05 GLU 699 -0.45 GLU 1593

THR 882 0.06 ASN 700 -0.46 GLU 1593

PHE 403 0.05 PRO 701 -0.44 GLU 1593

LYS 1488 0.05 ALA 702 -0.44 GLU 1593

LYS 1488 0.05 MET 703 -0.46 GLU 1593

LYS 1488 0.05 SER 704 -0.46 GLU 1593

HSD 431 0.05 ASP 705 -0.44 GLU 1593

MET 683 0.06 PRO 706 -0.44 GLU 1593

MET 683 0.07 ASP 707 -0.43 GLU 1593

MET 683 0.06 LEU 708 -0.43 GLU 1593

GLY 1027 0.10 ASN 709 -0.42 GLU 1593

GLU 1024 0.10 HSD 710 -0.40 GLU 1593

GLU 1024 0.07 ALA 711 -0.41 GLU 1593

THR 1028 0.09 ARG 712 -0.41 GLU 1593

GLU 1024 0.10 HSD 713 -0.40 GLU 1593

GLU 1024 0.09 ALA 714 -0.39 GLU 1593

THR 1028 0.08 LEU 715 -0.40 GLU 1593

THR 1028 0.09 ALA 716 -0.39 GLU 1593

MET 1022 0.10 MET 717 -0.37 GLU 1593

MET 1022 0.09 LEU 718 -0.37 GLU 1593

MET 1022 0.09 ASP 719 -0.36 GLU 1593

MET 1022 0.08 HSD 720 -0.37 GLU 1593

MET 1022 0.07 LEU 721 -0.39 GLU 1593

ALA 279 0.06 VAL 722 -0.39 GLU 1593

ALA 279 0.07 VAL 723 -0.42 GLU 1593

ASP 725 0.08 GLN 724 -0.43 GLU 1593

GLN 724 0.08 ASP 725 -0.45 GLU 1593

ASP 278 0.07 LEU 726 -0.48 GLU 1593

ALA 279 0.08 PHE 727 -0.48 GLU 1593

ALA 279 0.08 LEU 728 -0.46 GLU 1593

ALA 279 0.07 THR 729 -0.46 GLU 1593

ALA 279 0.07 GLU 730 -0.45 GLU 1593

ALA 279 0.06 THR 731 -0.44 GLU 1593

ALA 279 0.07 ALA 732 -0.43 GLU 1593

ALA 279 0.08 PHE 733 -0.42 GLU 1593

THR 1028 0.08 HSD 734 -0.41 GLU 1593

ALA 279 0.07 ALA 735 -0.40 GLU 1593

ALA 279 0.07 ASP 736 -0.38 GLU 1593

ALA 279 0.07 VAL 737 -0.39 GLU 1593

ALA 279 0.08 VAL 738 -0.41 GLU 1593

ALA 279 0.07 LEU 739 -0.41 GLU 1593

ASP 278 0.08 PRO 740 -0.43 GLU 1593

ASP 278 0.06 ALA 741 -0.45 GLU 1593

LYS 1488 0.07 SER 742 -0.47 GLU 1593

LYS 1488 0.07 ALA 743 -0.50 GLU 1593

LYS 1488 0.06 PHE 744 -0.51 GLU 1593

LYS 1488 0.07 ALA 745 -0.53 GLU 1593

LYS 1488 0.07 GLU 746 -0.50 GLU 1593

LYS 1488 0.06 LYS 747 -0.48 GLU 1593

LYS 1488 0.06 ALA 748 -0.47 GLU 1593

ASN 410 0.07 GLY 749 -0.47 GLU 1593

LYS 1488 0.05 THR 750 -0.47 GLU 1593

LYS 1488 0.06 PHE 751 -0.48 GLU 1593

LYS 1488 0.05 THR 752 -0.47 GLU 1593

LYS 1488 0.06 ASN 753 -0.49 GLU 1593

LYS 1488 0.05 THR 754 -0.48 GLU 1593

LYS 1488 0.05 ASP 755 -0.47 GLU 1593

THR 823 0.06 ARG 756 -0.46 GLU 1593

LYS 1488 0.05 ARG 757 -0.47 GLU 1593

ALA 821 0.06 VAL 758 -0.47 GLU 1593

LYS 1488 0.06 GLN 759 -0.49 GLU 1593

LYS 1488 0.06 ILE 760 -0.49 GLU 1593

LYS 1488 0.06 ALA 761 -0.50 GLU 1593

LYS 1488 0.06 GLN 762 -0.51 GLU 1593

GLY 793 0.07 PRO 763 -0.51 GLU 1593

LYS 1488 0.07 VAL 764 -0.54 GLU 1593

VAL 308 0.08 VAL 765 -0.53 GLU 1593

GLU 311 0.11 ALA 766 -0.49 GLU 1593

ARG 312 0.10 PRO 767 -0.48 GLU 1593

ARG 312 0.12 PRO 768 -0.48 GLU 1593

ARG 312 0.10 GLY 769 -0.45 GLU 1593

ASP 278 0.08 ASP 770 -0.43 GLU 1593

ASP 278 0.07 ALA 771 -0.44 GLU 1593

LYS 1488 0.06 ARG 772 -0.43 GLU 1593

GLU 311 0.07 GLN 773 -0.43 GLU 1593

LYS 1488 0.06 ASP 774 -0.43 GLU 1593

LYS 1488 0.06 TRP 775 -0.41 GLU 1593

GLU 311 0.06 TRP 776 -0.40 GLU 1593

GLU 311 0.06 ILE 777 -0.40 GLU 1593

GLY 668 0.05 ILE 778 -0.39 GLU 1593

GLY 668 0.07 GLN 779 -0.38 GLU 1593

GLY 668 0.06 GLU 780 -0.37 GLU 1593

ALA 279 0.06 LEU 781 -0.37 GLU 1593

GLY 668 0.06 ALA 782 -0.36 GLU 1593

GLY 668 0.06 ARG 783 -0.35 GLU 1593

ALA 279 0.06 ARG 784 -0.34 GLU 1593

GLN 669 0.06 LEU 785 -0.34 GLU 1593

GLN 669 0.07 ASP 786 -0.33 GLU 1593

GLY 668 0.08 LEU 787 -0.34 GLU 1593

GLY 668 0.09 ASP 788 -0.33 GLU 1593

GLY 668 0.08 TRP 789 -0.35 GLU 1593

GLY 668 0.07 ASN 790 -0.35 GLU 1593

GLY 668 0.06 TYR 791 -0.37 GLU 1593

PRO 763 0.06 GLY 792 -0.38 GLU 1593

PRO 763 0.07 GLY 793 -0.40 GLU 1593

LYS 1488 0.06 PRO 794 -0.42 GLU 1593

LYS 1488 0.05 ALA 795 -0.41 GLU 1593

LYS 1488 0.05 ASP 796 -0.39 GLU 1593

GLY 749 0.05 ILE 797 -0.40 GLU 1593

GLY 749 0.06 PHE 798 -0.41 GLU 1593

LYS 1488 0.04 ALA 799 -0.39 GLU 1593

LYS 1488 0.04 GLU 800 -0.38 GLU 1593

GLY 749 0.04 MET 801 -0.39 GLU 1593

GLY 749 0.03 ALA 802 -0.39 GLU 1593

LYS 1488 0.03 GLN 803 -0.37 GLU 1593

GLY 642 0.03 VAL 804 -0.42 PRO 843

ASP 650 0.07 MET 805 -0.40 PRO 843

ASP 650 0.08 PRO 806 -0.39 GLU 1593

ASP 640 0.08 SER 807 -0.41 GLU 1593

ASP 640 0.06 LEU 808 -0.41 GLU 1593

PRO 829 0.09 ASN 809 -0.40 GLU 1593

PRO 829 0.15 ASN 810 -0.40 GLU 1593

ASP 830 0.05 ILE 811 -0.42 GLU 1593

ASP 830 0.07 THR 812 -0.42 GLU 1593

LYS 1488 0.05 TRP 813 -0.43 GLU 1593

LYS 1488 0.05 GLU 814 -0.43 GLU 1593

THR 812 0.06 ARG 815 -0.44 GLU 1593

LYS 1488 0.05 LEU 816 -0.46 GLU 1593

LYS 1488 0.06 GLU 817 -0.47 GLU 1593

LYS 1488 0.05 ARG 818 -0.47 GLU 1593

PRO 832 0.06 GLU 819 -0.49 GLU 1593

LYS 1488 0.06 GLY 820 -0.50 GLU 1593

VAL 758 0.06 ALA 821 -0.49 GLU 1593

GLY 966 0.05 VAL 822 -0.47 GLU 1593

GLY 966 0.06 THR 823 -0.46 GLU 1593

HSD 437 0.07 TYR 824 -0.44 GLU 1593

ALA 438 0.08 PRO 825 -0.42 GLU 1593

ALA 438 0.07 VAL 826 -0.42 GLU 1593

PRO 829 0.07 ASP 827 -0.40 GLU 1593

PRO 829 0.11 ALA 828 -0.40 GLU 1593

ASN 810 0.15 PRO 829 -0.42 GLU 1593

ASN 810 0.07 ASP 830 -0.42 GLU 1593

LEU 965 0.05 GLN 831 -0.42 GLU 1593

GLU 819 0.06 PRO 832 -0.44 GLU 1593

ALA 438 0.05 GLY 833 -0.43 GLU 1593

ALA 452 0.06 ASN 834 -0.42 GLU 1593

LYS 1488 0.06 GLU 835 -0.43 GLU 1593

ILE 837 0.10 ILE 836 -0.41 GLU 1593

ILE 836 0.10 ILE 837 -0.40 GLU 1593

GLY 1484 0.08 PHE 838 -0.37 GLU 1593

PRO 1374 0.10 TYR 839 -0.36 GLU 1593

PRO 1374 0.10 ALA 840 -0.39 ALA 658

THR 1065 0.10 GLY 841 -0.45 ALA 658

THR 1065 0.09 PHE 842 -0.52 GLN 652

THR 1065 0.08 PRO 843 -0.67 GLN 652

THR 1065 0.09 THR 844 -0.74 LYS 656

THR 1065 0.09 GLU 845 -0.90 LYS 656

THR 1065 0.11 SER 846 -0.73 LYS 656

THR 1065 0.11 GLY 847 -0.63 LYS 656

THR 1065 0.12 ARG 848 -0.58 LYS 656

THR 1065 0.12 ALA 849 -0.54 LYS 656

THR 1065 0.13 LYS 850 -0.54 LYS 656

THR 1065 0.14 ILE 851 -0.45 LYS 656

THR 1065 0.13 VAL 852 -0.42 GLU 655

THR 1065 0.15 PRO 853 -0.36 GLU 655

THR 1065 0.14 ALA 854 -0.36 GLU 1593

THR 1065 0.14 ALA 855 -0.36 GLU 1593

VAL 1057 0.13 ILE 856 -0.36 GLU 1593

VAL 1057 0.11 VAL 857 -0.37 GLU 1593

ILE 940 0.10 PRO 858 -0.38 GLU 1593

PRO 939 0.07 PRO 859 -0.40 GLU 1593

VAL 600 0.10 ASP 860 -0.40 GLU 1593

VAL 600 0.05 GLU 861 -0.40 GLU 1593

PRO 858 0.08 VAL 862 -0.41 GLU 1593

PRO 858 0.08 PRO 863 -0.41 GLU 1593

PRO 858 0.06 ASP 864 -0.40 GLU 1593

ILE 856 0.06 ASP 865 -0.40 GLU 1593

ARG 684 0.04 GLU 866 -0.41 GLU 1593

PRO 858 0.04 PHE 867 -0.42 GLU 1593

PRO 858 0.07 PRO 868 -0.43 GLU 1593

SER 566 0.07 MET 869 -0.44 GLU 1593

PRO 858 0.08 VAL 870 -0.44 GLU 1593

PRO 517 0.06 LEU 871 -0.46 GLU 1593

PRO 517 0.06 SER 872 -0.47 GLU 1593

LYS 1488 0.04 THR 873 -0.48 GLU 1593

PRO 500 0.06 GLY 874 -0.50 GLU 1593

ALA 514 0.07 ARG 875 -0.52 GLU 1593

ALA 514 0.09 VAL 876 -0.55 GLU 1593

VAL 475 0.16 LEU 877 -0.57 GLU 1593

ALA 509 0.10 GLU 878 -0.59 GLU 1593

VAL 475 0.08 HSD 879 -0.56 GLU 1593

VAL 475 0.07 TRP 880 -0.53 GLU 1593

LYS 1488 0.05 HSD 881 -0.51 GLU 1593

ASN 700 0.06 THR 882 -0.50 GLU 1593

LYS 1488 0.06 GLY 883 -0.53 GLU 1593

THR 729 0.07 SER 884 -0.52 GLU 1593

LYS 1488 0.06 MET 885 -0.54 GLU 1593

ALA 509 0.07 THR 886 -0.56 GLU 1593

ALA 509 0.07 ARG 887 -0.56 GLU 1593

ALA 279 0.08 ARG 888 -0.56 GLU 1593

HSD 341 0.09 ALA 889 -0.59 GLU 1593

ALA 205 0.09 GLY 890 -0.62 GLU 1593

ALA 205 0.14 VAL 891 -0.65 GLU 1593

ALA 509 0.10 LEU 892 -0.62 GLU 1593

ALA 509 0.09 ASP 893 -0.60 GLU 1593

ALA 509 0.10 ALA 894 -0.64 GLU 1593

ALA 509 0.11 LEU 895 -0.64 GLU 1593

HSD 512 0.10 GLU 896 -0.60 GLU 1593

ASP 571 0.09 PRO 897 -0.59 GLU 1593

ASP 571 0.09 GLU 898 -0.56 GLU 1593

GLY 569 0.08 ALA 899 -0.53 GLU 1593

GLY 569 0.10 VAL 900 -0.53 GLU 1593

GLY 569 0.10 ALA 901 -0.52 GLU 1593

GLY 569 0.13 PHE 902 -0.52 GLU 1593

GLY 569 0.17 MET 903 -0.50 GLU 1593

GLY 569 0.21 ALA 904 -0.50 GLU 1593

GLY 569 0.20 PRO 905 -0.51 GLU 1593

GLY 569 0.21 LYS 906 -0.49 GLU 1593

GLY 569 0.18 GLU 907 -0.48 GLU 1593

GLY 569 0.16 LEU 908 -0.49 GLU 1593

SER 566 0.17 TYR 909 -0.48 GLU 1593

SER 566 0.17 ARG 910 -0.46 GLU 1593

SER 566 0.13 LEU 911 -0.46 GLU 1593

SER 566 0.13 GLY 912 -0.47 GLU 1593

SER 566 0.13 LEU 913 -0.50 GLU 1593

ASP 571 0.13 ARG 914 -0.52 GLU 1593

ASP 571 0.14 PRO 915 -0.54 GLU 1593

ASP 571 0.12 GLY 916 -0.55 GLU 1593

ASP 571 0.11 GLY 917 -0.53 GLU 1593

GLY 569 0.09 SER 918 -0.51 GLU 1593

GLY 569 0.09 MET 919 -0.49 GLU 1593

GLY 569 0.07 ARG 920 -0.47 GLU 1593

GLY 569 0.06 LEU 921 -0.46 GLU 1593

ARG 684 0.06 GLU 922 -0.44 GLU 1593

ARG 684 0.06 THR 923 -0.43 GLU 1593

ARG 684 0.07 ARG 924 -0.42 GLU 1593

ARG 684 0.08 ARG 925 -0.42 GLU 1593

ASN 709 0.09 GLY 926 -0.43 GLU 1593

ASN 709 0.09 ALA 927 -0.45 GLU 1593

ASN 709 0.09 VAL 928 -0.47 GLU 1593

ASN 360 0.07 VAL 929 -0.48 GLU 1593

GLY 569 0.08 LEU 930 -0.51 GLU 1593

GLY 569 0.10 LYS 931 -0.53 GLU 1593

GLY 569 0.12 VAL 932 -0.52 GLU 1593

GLY 569 0.13 ARG 933 -0.54 GLU 1593

GLY 569 0.16 SER 934 -0.54 GLU 1593

GLY 569 0.19 ASP 935 -0.54 GLU 1593

GLY 569 0.24 ARG 936 -0.52 GLU 1593

ALA 514 0.27 ASP 937 -0.52 GLU 1593

GLY 569 0.22 VAL 938 -0.50 GLU 1593

GLY 569 0.29 PRO 939 -0.48 GLU 1593

GLY 569 0.26 ILE 940 -0.46 GLU 1593

SER 566 0.16 GLY 941 -0.45 GLU 1593

GLY 569 0.14 MET 942 -0.47 GLU 1593

GLY 569 0.11 ILE 943 -0.48 GLU 1593

GLY 569 0.10 PHE 944 -0.49 GLU 1593

GLY 569 0.08 MET 945 -0.50 GLU 1593

ALA 514 0.07 PRO 946 -0.51 GLU 1593

LYS 1488 0.05 PHE 947 -0.50 GLU 1593

ASN 700 0.06 CYS 948 -0.52 GLU 1593

ALA 514 0.06 TYR 949 -0.51 GLU 1593

GLU 730 0.06 ALA 950 -0.49 GLU 1593

ASN 360 0.06 GLU 951 -0.49 GLU 1593

GLY 569 0.06 ALA 952 -0.49 GLU 1593

LYS 1488 0.05 ALA 953 -0.48 GLU 1593

LYS 1488 0.05 ALA 954 -0.47 GLU 1593

LYS 1488 0.05 ASN 955 -0.46 GLU 1593

MET 683 0.06 LEU 956 -0.45 GLU 1593

MET 683 0.06 LEU 957 -0.44 GLU 1593

LYS 1488 0.04 THR 958 -0.44 GLU 1593

SER 807 0.04 ASN 959 -0.42 GLU 1593

SER 807 0.05 PRO 960 -0.42 GLU 1593

SER 807 0.05 ALA 961 -0.40 GLU 1593

SER 807 0.06 LEU 962 -0.40 GLU 1593

PRO 825 0.06 ASP 963 -0.40 GLU 1593

ALA 438 0.07 PRO 964 -0.38 GLU 1593

ALA 438 0.11 LEU 965 -0.38 GLU 1593

ALA 438 0.16 GLY 966 -0.40 GLU 1593

SER 807 0.08 LYS 967 -0.40 GLU 1593

CYS 436 0.08 ILE 968 -0.42 GLU 1593

SER 807 0.05 PRO 969 -0.42 GLU 1593

PRO 825 0.05 GLU 970 -0.43 GLU 1593

LYS 1488 0.05 PHE 971 -0.45 GLU 1593

LYS 1488 0.05 LYS 972 -0.45 GLU 1593

LYS 1488 0.04 PHE 973 -0.44 GLU 1593

LYS 1488 0.04 CYS 974 -0.43 GLU 1593

PRO 858 0.04 ALA 975 -0.43 GLU 1593

ARG 684 0.04 ALA 976 -0.44 GLU 1593

SER 566 0.06 ARG 977 -0.44 GLU 1593

SER 566 0.08 VAL 978 -0.46 GLU 1593

SER 566 0.08 VAL 979 -0.46 GLU 1593

ALA 981 0.12 PRO 980 -0.47 GLU 1593

PRO 980 0.12 ALA 981 -0.48 GLU 1593

ASP 571 0.08 GLU 982 -0.49 GLU 1593

ASP 571 0.09 ALA 983 -0.51 GLU 1593

ASN 360 0.08 ALA 984 -0.51 GLU 1593

ASN 360 0.09 PRO 985 -0.50 GLU 1593

ASN 360 0.10 MET 986 -0.48 GLU 1593

ASN 360 0.12 ALA 987 -0.48 GLU 1593

ASN 360 0.10 ALA 988 -0.49 GLU 1593

ASN 360 0.09 GLU 989 -0.48 GLU 1593

ASP 358 0.11 MET 1022 -0.43 GLU 1593

ASN 360 0.10 SER 1023 -0.44 GLU 1593

HSD 713 0.10 GLU 1024 -0.43 GLU 1593

ASN 709 0.10 ALA 1025 -0.44 GLU 1593

ASN 709 0.10 SER 1026 -0.45 GLU 1593

ASN 360 0.12 GLY 1027 -0.45 GLU 1593

ASN 360 0.17 THR 1028 -0.44 GLU 1593

ASN 360 0.11 VAL 1029 -0.47 GLU 1593

ASN 360 0.07 ARG 1030 -0.46 GLU 1593

GLN 362 0.07 SER 1031 -0.49 GLU 1593

ALA 279 0.07 PHE 1032 -0.50 GLU 1593

ASP 364 0.13 ALA 1033 -0.51 GLU 1593

ALA 366 0.10 HSD 1034 -0.54 GLU 1593

ALA 366 0.11 PRO 1035 -0.56 GLU 1593

ALA 279 0.09 GLY 1036 -0.58 GLU 1593

ALA 279 0.08 ARG 1037 -0.56 GLU 1593

ALA 366 0.10 GLY 1038 -0.59 GLU 1593

ASP 571 0.09 ARG 1039 -0.61 GLU 1593

ASP 571 0.09 ASN 1040 -0.58 GLU 1593

ASP 571 0.10 VAL 1041 -0.59 GLU 1593

ASP 571 0.11 ALA 1042 -0.59 GLU 1593

ASP 571 0.13 ARG 1043 -0.60 GLU 1593

ASP 571 0.14 ALA 1044 -0.57 GLU 1593

ASP 571 0.17 VAL 1045 -0.58 GLU 1593

ASP 571 0.17 PRO 1046 -0.59 GLU 1593

ASP 571 0.16 LYS 1047 -0.63 GLU 1593

THR 574 0.18 GLY 1048 -0.65 GLU 1593

ASP 571 0.20 ARG 1049 -0.64 GLU 1593

ASP 571 0.23 GLN 1050 -0.60 GLU 1593

ASP 571 0.27 VAL 1051 -0.57 GLU 1593

ASP 571 0.27 ASP 1052 -0.55 GLU 1593

ASP 571 0.30 PRO 1053 -0.52 GLU 1593

ASP 571 0.30 HSD 1054 -0.52 GLU 1593

ASP 571 0.29 ALA 1055 -0.54 GLU 1593

ASP 571 0.34 LYS 1056 -0.53 GLU 1593

ASP 571 0.36 VAL 1057 -0.50 GLU 1593

GLU 573 0.32 GLU 1058 -0.51 GLU 1593

GLU 573 0.33 ILE 1059 -0.52 GLU 1593

GLU 573 0.38 GLU 1060 -0.49 GLU 1593

GLU 573 0.36 GLU 1061 -0.48 GLU 1593

GLU 573 0.32 LEU 1062 -0.49 GLU 1593

GLU 573 0.35 LEU 1063 -0.49 GLU 1593

GLU 573 0.38 GLY 1064 -0.46 GLU 1593

GLU 573 0.41 THR 1065 -0.45 GLU 1593

GLU 573 0.37 ARG 1066 -0.46 GLU 1593

GLU 573 0.37 PRO 1067 -0.47 GLU 1593

GLU 577 0.36 ARG 1068 -0.50 GLU 1593

GLU 577 0.34 GLN 1069 -0.50 GLU 1593

GLU 577 0.30 ARG 1070 -0.53 GLU 1593

GLU 577 0.26 ASP 1071 -0.52 GLU 1593

GLU 577 0.27 LEU 1072 -0.51 GLU 1593

GLU 573 0.26 LEU 1073 -0.55 GLU 1593

GLU 573 0.24 ILE 1074 -0.55 GLU 1593

GLU 573 0.25 GLU 1075 -0.51 GLU 1593

GLU 573 0.27 HSD 1076 -0.53 GLU 1593

GLU 573 0.25 LEU 1077 -0.56 GLU 1593

GLU 573 0.24 HSD 1078 -0.53 GLU 1593

GLU 573 0.26 LEU 1079 -0.51 GLU 1593

GLU 573 0.26 ILE 1080 -0.54 GLU 1593

GLU 573 0.23 GLN 1081 -0.55 GLU 1593

GLU 573 0.23 ASP 1082 -0.51 GLU 1593

GLU 573 0.24 THR 1083 -0.50 GLU 1593

GLU 573 0.23 TYR 1084 -0.53 GLU 1593

GLU 573 0.21 GLY 1085 -0.54 GLU 1593

GLU 573 0.22 GLN 1086 -0.59 GLU 1593

GLU 573 0.23 ILE 1087 -0.60 GLU 1593

GLU 573 0.23 SER 1088 -0.61 GLU 1593

GLU 573 0.23 ALA 1089 -0.64 GLU 1593

GLU 573 0.25 ASP 1090 -0.60 GLU 1593

GLU 573 0.27 HSD 1091 -0.58 GLU 1593

GLU 573 0.26 LEU 1092 -0.60 GLU 1593

THR 574 0.27 ALA 1093 -0.60 GLU 1593

GLU 573 0.30 ALA 1094 -0.56 GLU 1593

GLU 573 0.31 LEU 1095 -0.56 GLU 1593

THR 574 0.29 ALA 1096 -0.58 GLU 1593

THR 574 0.33 ASP 1097 -0.55 GLU 1593

THR 574 0.37 GLU 1098 -0.53 GLU 1593

THR 574 0.35 MET 1099 -0.53 GLU 1593

TYR 510 0.40 SER 1100 -0.54 GLU 1593

TYR 510 0.32 LEU 1101 -0.58 GLU 1593

TYR 510 0.29 ALA 1102 -0.61 GLU 1593

TYR 510 0.24 PHE 1103 -0.64 GLU 1593

TYR 510 0.21 ALA 1104 -0.68 GLU 1593

TYR 510 0.23 GLU 1105 -0.64 GLU 1593

GLU 577 0.23 VAL 1106 -0.63 GLU 1593

GLU 573 0.21 PHE 1107 -0.67 GLU 1593

GLU 577 0.19 GLU 1108 -0.69 GLU 1593

GLU 577 0.20 THR 1109 -0.65 GLU 1593

GLU 573 0.21 ALA 1110 -0.64 GLU 1593

GLU 573 0.19 THR 1111 -0.70 GLU 1593

GLU 573 0.18 PHE 1112 -0.68 GLU 1593

GLU 573 0.19 TYR 1113 -0.64 GLU 1593

GLU 573 0.18 ALA 1114 -0.64 GLU 1593

GLU 573 0.19 HSD 1115 -0.59 GLU 1593

GLU 573 0.20 PHE 1116 -0.62 GLU 1593

GLU 573 0.20 ASP 1117 -0.64 GLU 1593

GLU 573 0.21 VAL 1118 -0.66 GLU 1593

GLU 573 0.21 VAL 1119 -0.67 GLU 1593

GLU 573 0.20 LYS 1120 -0.68 GLU 1593

ASP 571 0.20 GLU 1121 -0.66 GLU 1593

ASP 571 0.19 GLY 1122 -0.67 GLU 1593

GLU 573 0.19 GLU 1123 -0.68 GLU 1593

GLU 573 0.19 ALA 1124 -0.65 GLU 1593

GLU 573 0.20 ASP 1125 -0.62 GLU 1593

GLU 573 0.19 ILE 1126 -0.59 GLU 1593

GLU 573 0.18 PRO 1127 -0.54 GLU 1593

GLU 573 0.17 ARG 1128 -0.50 GLU 1593

GLU 573 0.16 LEU 1129 -0.48 GLU 1593

GLU 573 0.16 THR 1130 -0.51 GLU 1593

GLU 573 0.15 ILE 1131 -0.48 GLU 1593

GLU 573 0.15 ARG 1132 -0.49 GLU 1593

GLU 573 0.14 VAL 1133 -0.45 GLU 1593

GLU 573 0.13 CYS 1134 -0.44 GLU 1593

GLU 573 0.13 ASP 1135 -0.46 ALA 1592

ASP 1582 0.13 SER 1136 -0.45 ALA 1592

ASP 1582 0.18 ILE 1137 -0.40 ALA 1592

ASP 1582 0.20 THR 1138 -0.33 ALA 1592

ASP 1582 0.16 CYS 1139 -0.35 ALA 1592

ASP 1582 0.14 ALA 1140 -0.36 ALA 1592

ASP 1582 0.20 MET 1141 -0.29 ALA 1592

ASP 1582 0.18 PHE 1142 -0.26 ALA 1592

ASP 1582 0.13 GLY 1143 -0.29 ALA 1592

GLU 573 0.13 ALA 1144 -0.37 GLU 1593

GLU 573 0.13 ASP 1145 -0.41 GLU 1593

GLU 573 0.13 GLU 1146 -0.36 GLU 1593

GLU 573 0.13 LEU 1147 -0.37 GLU 1593

GLU 573 0.14 LEU 1148 -0.44 GLU 1593

GLU 573 0.13 GLU 1149 -0.45 GLU 1593

GLU 573 0.13 THR 1150 -0.39 GLU 1593

GLU 573 0.14 LEU 1151 -0.42 GLU 1593

GLU 573 0.15 GLN 1152 -0.48 GLU 1593

GLU 573 0.14 ARG 1153 -0.44 GLU 1593

GLU 573 0.13 GLU 1154 -0.40 GLU 1593

GLU 573 0.14 LEU 1155 -0.43 GLU 1593

GLU 573 0.15 ALA 1156 -0.49 GLU 1593

GLU 573 0.16 SER 1157 -0.49 GLU 1593

GLU 573 0.17 ASP 1158 -0.52 GLU 1593

GLU 573 0.16 ALA 1159 -0.50 GLU 1593

GLU 573 0.16 VAL 1160 -0.49 GLU 1593

GLU 573 0.16 ARG 1161 -0.54 GLU 1593

GLU 573 0.15 VAL 1162 -0.52 GLU 1593

GLU 573 0.16 VAL 1163 -0.56 GLU 1593

GLU 573 0.15 ARG 1164 -0.55 GLU 1593

GLU 573 0.15 ALA 1165 -0.53 GLU 1593

GLU 573 0.14 PRO 1166 -0.51 GLU 1593

GLU 573 0.13 CYS 1167 -0.44 ALA 1592

GLU 573 0.13 VAL 1168 -0.42 GLU 1593

ASP 1582 0.16 GLY 1169 -0.37 ALA 1592

ASP 1582 0.17 LEU 1170 -0.33 ALA 1592

ASP 1582 0.20 CYS 1171 -0.31 ALA 1592

ASP 1582 0.22 ASP 1172 -0.26 ALA 1592

ASP 1582 0.19 HSD 1173 -0.26 ALA 1592

ASP 1582 0.18 ALA 1174 -0.29 ALA 1592

ASP 1582 0.15 PRO 1175 -0.31 GLU 1593

ASP 1582 0.13 ALA 1176 -0.35 GLU 1593

GLU 573 0.13 VAL 1177 -0.39 GLU 1593

GLU 573 0.14 GLU 1178 -0.42 GLU 1593

GLU 573 0.14 VAL 1179 -0.42 GLU 1593

GLU 573 0.15 GLY 1180 -0.44 GLU 1593

GLU 573 0.14 HSD 1181 -0.42 GLU 1593

GLU 573 0.13 ASN 1182 -0.38 GLU 1593

GLU 534 0.12 PHE 1183 -0.37 GLU 1593

ASP 1582 0.13 LEU 1184 -0.33 GLU 1593

ASP 1582 0.15 HSD 1185 -0.29 GLU 1593

ASP 1582 0.16 ARG 1186 -0.26 GLU 1593

ASP 1582 0.13 ALA 1187 -0.30 GLU 1593

ASP 1582 0.11 ASP 1188 -0.29 GLU 1593

GLU 573 0.12 LEU 1189 -0.31 GLU 1593

GLU 573 0.11 ALA 1190 -0.28 GLU 1593

GLU 573 0.11 SER 1191 -0.29 GLU 1593

GLU 573 0.12 VAL 1192 -0.34 GLU 1593

GLU 573 0.12 ARG 1193 -0.34 GLU 1593

GLU 573 0.11 ALA 1194 -0.31 GLU 1593

GLU 573 0.12 ALA 1195 -0.34 GLU 1593

GLU 573 0.13 VAL 1196 -0.38 GLU 1593

GLU 573 0.12 GLU 1197 -0.35 GLU 1593

GLU 573 0.11 ALA 1198 -0.33 GLU 1593

GLU 573 0.12 GLU 1199 -0.37 GLU 1593

GLU 573 0.11 ASP 1200 -0.35 GLU 1593

GLU 573 0.13 THR 1201 -0.39 GLU 1593

GLU 534 0.12 HSD 1202 -0.38 GLU 1593

GLU 534 0.12 ALA 1203 -0.36 GLU 1593

ASP 1582 0.13 HSD 1204 -0.32 GLU 1593

ASP 1582 0.13 ILE 1205 -0.31 GLU 1593

ASP 1582 0.16 PRO 1206 -0.26 GLU 1593

ASP 1582 0.17 THR 1207 -0.24 GLU 1593

ASP 1582 0.17 TYR 1208 -0.24 GLU 1593

ASP 1582 0.17 VAL 1209 -0.23 GLU 1593

ASP 1582 0.15 ASP 1210 -0.26 GLU 1593

ASP 1582 0.13 TYR 1211 -0.26 GLU 1593

ASP 1582 0.14 ASP 1212 -0.24 GLU 1593

ASP 1582 0.16 ALA 1213 -0.21 GLU 1593

ASP 1582 0.16 TYR 1214 -0.22 GLU 1593

ASP 1582 0.14 ARG 1215 -0.22 GLU 1593

ASP 1582 0.15 ALA 1216 -0.20 GLU 1593

ASP 1582 0.17 GLY 1217 -0.19 GLU 1593

ASP 1582 0.15 GLY 1218 -0.20 GLU 1593

ASP 1582 0.15 GLY 1219 -0.22 GLU 1593

ASP 1582 0.13 TYR 1220 -0.25 GLU 1593

ASP 1582 0.13 ALA 1221 -0.23 GLU 1593

ASP 1582 0.13 THR 1222 -0.23 GLU 1593

ASP 1582 0.11 LEU 1223 -0.26 GLU 1593

ASP 1582 0.11 GLU 1224 -0.25 GLU 1593

ASP 1582 0.11 ARG 1225 -0.24 GLU 1593

GLY 535 0.10 LEU 1226 -0.26 GLU 1593

GLY 535 0.10 ARG 1227 -0.28 GLU 1593

ASP 1582 0.09 SER 1228 -0.26 GLU 1593

GLY 535 0.09 GLY 1229 -0.25 GLU 1593

ASP 1582 0.10 GLU 1230 -0.23 GLU 1593

ASP 1582 0.10 LEU 1231 -0.23 GLU 1593

GLY 535 0.12 PRO 1232 -0.24 GLU 1593

GLY 535 0.14 VAL 1233 -0.27 GLU 1593

GLY 535 0.14 ASP 1234 -0.25 GLU 1593

GLY 535 0.12 ASP 1235 -0.23 ALA 1592

GLY 535 0.13 VAL 1236 -0.24 ALA 1592

GLY 535 0.15 LEU 1237 -0.26 ALA 1592

GLN 540 0.14 LYS 1238 -0.23 ALA 1592

GLY 535 0.13 VAL 1239 -0.21 ALA 1592

GLY 535 0.14 LEU 1240 -0.24 ALA 1592

GLN 540 0.15 ASP 1241 -0.23 ALA 1592

GLN 540 0.14 ASP 1242 -0.20 ALA 1592

ASP 1582 0.14 GLY 1243 -0.20 ALA 1592

GLN 540 0.14 GLY 1244 -0.22 ALA 1592

GLY 535 0.14 LEU 1245 -0.24 ALA 1592

GLY 535 0.15 ARG 1246 -0.27 ALA 1592

GLY 535 0.15 GLY 1247 -0.31 ALA 1592

ASP 1582 0.16 LEU 1248 -0.31 ALA 1592

GLY 535 0.15 GLY 1249 -0.36 ALA 1592

LEU 536 0.15 GLY 1250 -0.35 ALA 1592

LEU 536 0.16 ALA 1251 -0.36 ALA 1592

GLY 535 0.16 GLY 1252 -0.31 ALA 1592

GLY 535 0.16 PHE 1253 -0.32 ALA 1592

GLY 535 0.16 PRO 1254 -0.29 ALA 1592

GLY 535 0.16 THR 1255 -0.30 ALA 1592

GLY 535 0.16 GLY 1256 -0.28 ALA 1592

GLY 535 0.17 ARG 1257 -0.30 ALA 1592

GLY 535 0.18 LYS 1258 -0.34 ALA 1592

GLY 535 0.17 TRP 1259 -0.33 GLU 1593

GLY 535 0.18 ARG 1260 -0.31 GLU 1593

GLY 535 0.20 SER 1261 -0.35 GLU 1593

GLY 535 0.20 VAL 1262 -0.37 GLU 1593

GLY 535 0.19 ARG 1263 -0.35 GLU 1593

GLY 535 0.20 GLY 1264 -0.35 GLU 1593

GLY 535 0.22 GLU 1265 -0.38 GLU 1593

GLY 535 0.24 PRO 1266 -0.39 GLU 1593

GLY 535 0.24 GLY 1267 -0.39 GLU 1593

GLY 535 0.24 PRO 1268 -0.40 GLU 1593

GLY 535 0.22 ARG 1269 -0.40 GLU 1593

GLU 534 0.21 LEU 1270 -0.41 GLU 1593

GLU 534 0.19 MET 1271 -0.40 GLU 1593

GLU 534 0.18 ALA 1272 -0.42 GLU 1593

GLU 534 0.16 VAL 1273 -0.40 GLU 1593

GLU 534 0.16 ASN 1274 -0.42 GLU 1593

GLU 534 0.15 GLY 1275 -0.41 GLU 1593

GLU 534 0.15 ASP 1276 -0.45 GLU 1593

GLU 534 0.14 GLU 1277 -0.41 ALA 1592

GLU 534 0.14 GLY 1278 -0.45 ALA 1592

ASP 1582 0.15 GLU 1279 -0.43 ALA 1592

ASP 1582 0.17 PRO 1280 -0.41 ALA 1592

ASP 1582 0.21 GLY 1281 -0.34 ALA 1592

ASP 1582 0.19 THR 1282 -0.34 ALA 1592

ASP 1582 0.19 PHE 1283 -0.32 ALA 1592

ASP 1582 0.19 LYS 1284 -0.29 ALA 1592

ASP 1582 0.16 ASP 1285 -0.32 ALA 1592

ASP 1582 0.16 GLN 1286 -0.32 GLU 1593

ASP 1582 0.19 LEU 1287 -0.27 ALA 1592

ASP 1582 0.17 TYR 1288 -0.27 GLU 1593

ASP 1582 0.15 LEU 1289 -0.31 GLU 1593

ASP 1582 0.16 ASN 1290 -0.29 GLU 1593

ASP 1582 0.17 THR 1291 -0.25 GLU 1593

ASP 1582 0.16 ASP 1292 -0.25 GLU 1593

ASP 1582 0.14 PRO 1293 -0.29 GLU 1593

ASP 1582 0.14 HSD 1294 -0.28 GLU 1593

ASP 1582 0.15 ARG 1295 -0.26 GLU 1593

ASP 1582 0.14 PHE 1296 -0.29 GLU 1593

ASP 1582 0.12 LEU 1297 -0.31 GLU 1593

ASP 1582 0.12 GLU 1298 -0.28 GLU 1593

GLY 535 0.13 GLY 1299 -0.29 GLU 1593

GLU 534 0.14 MET 1300 -0.33 GLU 1593

GLU 534 0.13 LEU 1301 -0.32 GLU 1593

GLY 535 0.13 ILE 1302 -0.30 GLU 1593

GLY 535 0.15 GLY 1303 -0.32 GLU 1593

GLU 534 0.16 ALA 1304 -0.34 GLU 1593

GLY 535 0.15 HSD 1305 -0.32 GLU 1593

GLY 535 0.16 VAL 1306 -0.31 GLU 1593

GLY 535 0.18 VAL 1307 -0.35 GLU 1593

GLY 535 0.18 GLU 1308 -0.35 GLU 1593

GLU 534 0.18 ALA 1309 -0.38 GLU 1593

GLU 534 0.19 ALA 1310 -0.38 GLU 1593

GLU 534 0.19 ASP 1311 -0.40 GLU 1593

GLU 534 0.18 VAL 1312 -0.40 GLU 1593

GLU 534 0.18 TYR 1313 -0.43 GLU 1593

GLU 534 0.17 ILE 1314 -0.42 GLU 1593

GLU 534 0.17 TYR 1315 -0.45 GLU 1593

GLU 534 0.15 LEU 1316 -0.44 GLU 1593

GLU 534 0.15 ARG 1317 -0.46 GLU 1593

GLU 573 0.16 ASP 1318 -0.48 GLU 1593

GLU 573 0.15 GLU 1319 -0.45 GLU 1593

GLU 534 0.14 TYR 1320 -0.40 GLU 1593

GLU 534 0.13 PRO 1321 -0.40 GLU 1593

ASP 1582 0.12 ILE 1322 -0.35 GLU 1593

GLU 534 0.13 SER 1323 -0.36 GLU 1593

GLU 534 0.13 ARG 1324 -0.39 GLU 1593

GLU 534 0.12 GLU 1325 -0.37 GLU 1593

ASP 1582 0.12 ILE 1326 -0.33 GLU 1593

GLU 534 0.12 LEU 1327 -0.35 GLU 1593

GLU 534 0.12 ALA 1328 -0.37 GLU 1593

ASP 1582 0.11 ARG 1329 -0.34 GLU 1593

ASP 1582 0.12 GLU 1330 -0.32 GLU 1593

GLU 534 0.11 ILE 1331 -0.34 GLU 1593

GLU 534 0.09 ALA 1332 -0.35 GLU 1593

ASP 1582 0.10 LYS 1333 -0.31 GLU 1593

ASP 1582 0.11 LEU 1334 -0.31 GLU 1593

ASP 1582 0.10 PRO 1335 -0.31 GLU 1593

ASP 1582 0.08 GLU 1336 -0.33 GLU 1593

GLU 534 0.10 GLY 1337 -0.33 GLU 1593

GLU 534 0.12 GLY 1338 -0.34 GLU 1593

GLU 534 0.14 THR 1339 -0.36 GLU 1593

GLU 534 0.15 ARG 1340 -0.38 GLU 1593

GLU 534 0.15 ILE 1341 -0.39 GLU 1593

GLU 534 0.18 HSD 1342 -0.42 GLU 1593

GLU 534 0.17 LEU 1343 -0.42 GLU 1593

GLU 534 0.18 ARG 1344 -0.46 GLU 1593

GLU 573 0.18 ARG 1345 -0.48 GLU 1593

GLU 573 0.18 GLY 1346 -0.52 GLU 1593

GLU 573 0.19 ALA 1347 -0.55 GLU 1593

GLU 573 0.17 GLY 1348 -0.56 GLU 1593

GLU 573 0.17 ALA 1349 -0.59 GLU 1593

GLU 577 0.15 TYR 1350 -0.54 GLU 1593

GLU 577 0.15 ILE 1351 -0.57 GLU 1593

GLU 577 0.16 CYS 1352 -0.54 GLU 1593

GLU 534 0.15 GLY 1353 -0.48 GLU 1593

LEU 536 0.15 GLU 1354 -0.50 GLU 1593

LEU 536 0.16 GLU 1355 -0.47 GLU 1593

LEU 536 0.17 SER 1356 -0.51 GLU 1593

GLU 577 0.17 SER 1357 -0.55 GLU 1593

GLU 577 0.17 LEU 1358 -0.52 GLU 1593

GLU 577 0.18 ILE 1359 -0.51 GLU 1593

GLU 577 0.20 GLU 1360 -0.56 GLU 1593

GLU 577 0.20 SER 1361 -0.55 GLU 1593

GLU 577 0.20 LEU 1362 -0.51 GLU 1593

GLU 577 0.23 GLU 1363 -0.53 GLU 1593

GLU 577 0.23 GLY 1364 -0.56 GLU 1593

GLU 577 0.22 LYS 1365 -0.60 GLU 1593

GLU 577 0.19 ARG 1366 -0.63 GLU 1593

GLU 577 0.18 GLY 1367 -0.60 GLU 1593

GLU 577 0.17 LEU 1368 -0.63 GLU 1593

GLU 577 0.16 PRO 1369 -0.59 GLU 1593

LEU 536 0.16 ARG 1370 -0.57 GLU 1593

LEU 536 0.15 HSD 1371 -0.56 GLU 1593

ALA 1251 0.15 LYS 1372 -0.50 GLU 1593

LEU 536 0.15 PRO 1373 -0.47 PRO 1374

ARG 584 0.19 PRO 1374 -0.48 GLU 1593

LEU 536 0.19 PHE 1375 -0.46 GLU 1593

LEU 536 0.19 PRO 1376 -0.46 GLU 1593

LEU 536 0.19 PHE 1377 -0.42 GLU 1593

LEU 536 0.21 GLN 1378 -0.43 GLU 1593

LEU 536 0.21 VAL 1379 -0.46 GLU 1593

LEU 536 0.21 GLY 1380 -0.47 GLU 1593

LEU 536 0.21 LEU 1381 -0.48 GLU 1593

ARG 580 0.24 PHE 1382 -0.49 GLU 1593

ARG 584 0.24 ASN 1383 -0.49 GLU 1593

LEU 536 0.24 ARG 1384 -0.45 GLU 1593

LEU 536 0.22 PRO 1385 -0.42 GLU 1593

GLY 535 0.20 THR 1386 -0.42 GLU 1593

GLY 535 0.18 LEU 1387 -0.39 GLU 1593

GLU 534 0.17 ILE 1388 -0.40 GLU 1593

GLU 534 0.16 ASN 1389 -0.37 GLU 1593

GLU 534 0.15 ASN 1390 -0.36 ALA 1592

GLU 534 0.14 ILE 1391 -0.34 GLU 1593

ASP 1582 0.16 GLU 1392 -0.30 ALA 1592

ASP 1582 0.14 THR 1393 -0.30 ALA 1592

GLY 535 0.14 LEU 1394 -0.30 ALA 1592

ASP 1582 0.15 PHE 1395 -0.27 ALA 1592

ASP 1582 0.16 TRP 1396 -0.24 ALA 1592

ASP 1582 0.14 VAL 1397 -0.25 ALA 1592

ASP 1582 0.15 ARG 1398 -0.23 ALA 1592

ASP 1582 0.17 ASP 1399 -0.20 ALA 1592

ASP 1582 0.16 LEU 1400 -0.20 ALA 1592

ASP 1582 0.14 ILE 1401 -0.21 ALA 1592

ASP 1582 0.15 GLU 1402 -0.19 ALA 1592

ASP 1582 0.16 ARG 1403 -0.17 ALA 1592

ASP 1582 0.15 GLY 1404 -0.17 ALA 1592

ASP 1582 0.15 ALA 1405 -0.17 ALA 1592

ASP 1582 0.16 GLU 1406 -0.14 ALA 1592

ASP 1582 0.18 TRP 1407 -0.14 ALA 1592

ASP 1582 0.18 TRP 1408 -0.16 ALA 1592

ASP 1582 0.18 LYS 1409 -0.14 ALA 1592

ASP 1582 0.20 SER 1410 -0.11 ALA 1592

ASP 1582 0.22 HSD 1411 -0.12 ALA 1592

ASP 1582 0.24 GLY 1412 -0.11 ALA 1592

ASP 1582 0.27 ARG 1413 -0.07 ALA 1592

ASP 1582 0.27 ASN 1414 -0.05 ALA 1592

GLY 124 0.24 GLY 1415 -0.07 ALA 1592

GLY 124 0.23 ARG 1416 -0.11 ALA 1592

ASP 1582 0.21 VAL 1417 -0.14 ALA 1592

ASP 1582 0.20 GLY 1418 -0.16 ALA 1592

ASP 1582 0.22 LEU 1419 -0.17 ALA 1592

ASP 1582 0.23 ARG 1420 -0.20 ALA 1592

ASP 1582 0.23 SER 1421 -0.22 ALA 1592

ASP 1582 0.25 TYR 1422 -0.22 ALA 1592

ASP 1582 0.24 SER 1423 -0.26 ALA 1592

ASP 1582 0.28 VAL 1424 -0.22 ALA 1592

ASP 1582 0.27 SER 1425 -0.24 ALA 1592

ASP 1582 0.29 GLY 1426 -0.22 ALA 1592

ASP 1582 0.33 ARG 1427 -0.16 ALA 1592

ASP 1582 0.32 VAL 1428 -0.13 ALA 1592

ASP 1582 0.28 LYS 1429 -0.12 ALA 1592

ASP 1582 0.27 GLU 1430 -0.15 ALA 1592

ASP 1582 0.26 PRO 1431 -0.19 ALA 1592

ASP 1582 0.24 GLY 1432 -0.22 ALA 1592

ASP 1582 0.23 VAL 1433 -0.22 ALA 1592

ASP 1582 0.25 LYS 1434 -0.18 ALA 1592

ASP 1582 0.24 LEU 1435 -0.18 ALA 1592

ASP 1582 0.26 ALA 1436 -0.14 ALA 1592

ASP 1582 0.26 PRO 1437 -0.13 ALA 1592

ASP 1582 0.24 ALA 1438 -0.15 ALA 1592

ASP 1582 0.27 GLY 1439 -0.12 ALA 1592

ASP 1582 0.30 LEU 1440 -0.10 ALA 1592

ASP 1582 0.35 THR 1441 -0.08 ALA 1592

ASP 1582 0.39 ILE 1442 -0.10 ALA 1592

ASP 1582 0.41 GLN 1443 -0.06 PHE 1142

ASP 1582 0.35 GLU 1444 -0.06 PHE 1142

ASP 1582 0.33 LEU 1445 -0.11 ALA 1592

ASP 1582 0.36 ILE 1446 -0.09 ALA 1592

ASP 1582 0.35 ASP 1447 -0.07 PHE 1142

ASP 1582 0.31 GLU 1448 -0.07 PHE 1142

ASP 1582 0.29 TYR 1449 -0.11 ALA 1592

ASP 1582 0.30 CYS 1450 -0.12 ALA 1592

ASP 1582 0.30 GLY 1451 -0.10 PHE 1142

ASP 1582 0.35 GLY 1452 -0.10 PHE 1142

ASP 1582 0.37 ILE 1453 -0.10 PHE 1142

ASP 1582 0.30 SER 1454 -0.13 PHE 1142

ASP 1582 0.29 ASP 1455 -0.11 GLY 1143

ASP 1582 0.29 GLY 1456 -0.11 GLY 1143

ASP 1582 0.35 HSD 1457 -0.10 GLY 1143

ASP 1582 0.44 SER 1458 -0.08 GLY 1143

ASP 1582 0.50 PHE 1459 -0.07 PHE 1142

ASP 1582 0.61 ALA 1460 -0.15 SER 1502

ASP 1582 0.55 ALA 1461 -0.13 ALA 1592

ASP 1582 0.42 TYR 1462 -0.19 ALA 1592

ASP 1582 0.33 LEU 1463 -0.27 ALA 1592

ASP 1582 0.31 PRO 1464 -0.25 ALA 1592

ASP 1582 0.24 GLY 1465 -0.31 ALA 1592

ASP 1582 0.22 GLY 1466 -0.36 ALA 1592

ASP 1582 0.18 ALA 1467 -0.43 ALA 1592

LEU 1565 0.16 SER 1468 -0.44 ALA 1592

ASP 1582 0.21 GLY 1469 -0.35 ALA 1592

ASP 1582 0.24 GLY 1470 -0.34 ALA 1592

ASP 1582 0.34 ILE 1471 -0.28 ALA 1592

ASP 1582 0.46 LEU 1472 -0.18 ALA 1592

ASP 1582 0.65 PRO 1473 -0.09 ALA 1592

ASP 1582 0.60 ALA 1474 -0.11 SER 1502

ASP 1582 0.60 SER 1475 -0.09 SER 1502

ASP 1582 0.48 MET 1476 -0.06 SER 1502

ASP 1582 0.43 ASN 1477 -0.06 SER 1502

ASP 1582 0.39 ASP 1478 -0.05 PHE 1142

ASP 1582 0.35 ILE 1479 -0.07 ALA 1592

ASP 1582 0.30 PRO 1480 -0.10 ALA 1592

ASP 1582 0.28 LEU 1481 -0.16 ALA 1592

GLY 124 0.23 ASP 1482 -0.19 ALA 1592

GLY 124 0.25 PHE 1483 -0.23 ALA 1592

ARG 126 0.33 GLY 1484 -0.21 ALA 1592

GLY 124 0.32 THR 1485 -0.16 ALA 1592

ARG 126 0.32 LEU 1486 -0.20 ALA 1592

ARG 126 0.42 GLU 1487 -0.23 ALA 1592

ARG 126 0.40 LYS 1488 -0.16 ALA 1592

ARG 126 0.33 TYR 1489 -0.17 ALA 1592

ARG 126 0.35 GLY 1490 -0.26 ALA 1592

ARG 126 0.30 CYS 1491 -0.28 ALA 1592

ARG 126 0.28 PHE 1492 -0.29 ALA 1592

ASP 1582 0.22 ILE 1493 -0.27 ALA 1592

ASP 1582 0.19 GLY 1494 -0.32 ALA 1592

ASP 1582 0.19 SER 1495 -0.32 ALA 1592

ASP 1582 0.23 ALA 1496 -0.27 ALA 1592

ASP 1582 0.24 ALA 1497 -0.30 ALA 1592

ASP 1582 0.29 VAL 1498 -0.25 ALA 1592

ASP 1582 0.30 VAL 1499 -0.26 ALA 1592

ASP 1582 0.37 ILE 1500 -0.19 ALA 1592

ASP 1582 0.40 LEU 1501 -0.18 ALA 1592

ASP 1582 0.38 SER 1502 -0.15 ALA 1460

ASP 1582 0.40 ASP 1503 -0.08 ALA 1592

ASP 1582 0.30 GLN 1504 -0.13 ALA 1592

ASP 1582 0.31 ASP 1505 -0.20 ALA 1592

ASP 1582 0.27 ASP 1506 -0.24 ALA 1592

ASP 1582 0.34 VAL 1507 -0.26 ALA 1592

ASP 1582 0.16 ARG 1508 -0.36 ALA 1592

ASP 1582 0.15 GLY 1509 -0.40 ALA 1592

ASP 1582 0.20 ALA 1510 -0.40 ALA 1592

ASP 1582 0.16 ALA 1511 -0.47 ALA 1592

GLU 573 0.10 LEU 1512 -0.58 ALA 1592

ASP 1582 0.11 ASN 1513 -0.53 ALA 1592

ASP 1582 0.14 LEU 1514 -0.53 ALA 1592

GLU 573 0.11 MET 1515 -0.64 ALA 1592

GLU 573 0.11 LYS 1516 -0.67 ALA 1592

GLU 573 0.12 PHE 1517 -0.59 ALA 1592

GLU 573 0.12 PHE 1518 -0.65 ALA 1592

GLU 573 0.12 GLU 1519 -0.75 ALA 1592

GLU 573 0.13 ASP 1520 -0.70 ALA 1592

GLU 573 0.13 GLU 1521 -0.64 GLU 1593

GLU 577 0.13 SER 1522 -0.68 GLU 1593

GLU 577 0.14 CYS 1523 -0.69 GLU 1593

GLU 577 0.14 GLY 1524 -0.77 GLU 1593

GLU 577 0.14 GLN 1525 -0.73 GLU 1593

GLY 1490 0.13 CYS 1526 -0.73 GLU 1593

GLY 1490 0.13 THR 1527 -0.81 GLU 1593

GLY 1490 0.15 PRO 1528 -0.76 ALA 1592

GLY 1490 0.14 CYS 1529 -0.73 ALA 1592

GLU 577 0.11 ARG 1530 -0.80 GLU 1593

GLU 577 0.11 SER 1531 -0.92 ALA 1592

GLY 1490 0.11 GLY 1532 -0.87 ALA 1592

GLU 573 0.10 THR 1533 -0.82 ALA 1592

ASP 1145 0.09 GLN 1534 -0.92 ALA 1592

SER 1574 0.10 LYS 1535 -1.04 ALA 1592

SER 1574 0.12 ALA 1536 -0.88 ALA 1592

GLU 573 0.08 ARG 1537 -0.85 ALA 1592

GLU 573 0.08 MET 1538 -1.01 ALA 1592

GLU 147 0.08 LEU 1539 -1.00 ALA 1592

ARG 148 0.08 MET 1540 -0.76 ALA 1592

GLU 573 0.08 GLU 1541 -0.80 ALA 1591

GLU 147 0.07 ASN 1542 -0.82 ALA 1591

GLU 147 0.08 GLY 1543 -0.57 ALA 1591

GLU 147 0.10 VAL 1544 -0.63 PRO 1585

GLU 147 0.11 TRP 1545 -0.61 ALA 1592

GLU 147 0.12 ASP 1546 -0.79 PRO 1587

GLU 147 0.15 THR 1547 -0.52 ALA 1592

GLU 147 0.19 ASP 1548 -0.54 ALA 1592

GLU 147 0.14 LEU 1549 -0.77 ALA 1592

SER 1574 0.13 LEU 1550 -0.70 ALA 1592

SER 1574 0.18 GLY 1551 -0.53 ALA 1592

ARG 148 0.18 GLU 1552 -0.62 ALA 1592

SER 1574 0.16 LEU 1553 -0.74 ALA 1592

SER 1574 0.25 ALA 1554 -0.60 ALA 1592

GLY 1490 0.21 GLN 1555 -0.53 ALA 1592

GLY 1490 0.18 CYS 1556 -0.63 ALA 1592

GLY 1490 0.19 MET 1557 -0.63 ALA 1592

GLY 1490 0.27 ARG 1558 -0.53 ALA 1592

GLY 1490 0.24 ASP 1559 -0.51 ALA 1592

GLY 1490 0.19 ALA 1560 -0.59 ALA 1592

GLY 1490 0.17 SER 1561 -0.61 ALA 1592

GLU 1487 0.16 ILE 1562 -0.58 GLU 1593

GLU 1487 0.16 CYS 1563 -0.54 ALA 1592

PHE 1492 0.19 GLY 1564 -0.50 ALA 1592

SER 1468 0.16 LEU 1565 -0.56 ALA 1592

CYS 1529 0.13 GLY 1566 -0.61 ALA 1592

GLY 1490 0.17 GLN 1567 -0.53 ALA 1592

CYS 1491 0.16 ALA 1568 -0.50 ALA 1592

GLU 577 0.11 ALA 1569 -0.58 ALA 1592

MET 1557 0.13 SER 1570 -0.57 ALA 1592

ASP 1582 0.18 ASN 1571 -0.44 ALA 1592

ASP 1582 0.21 PRO 1572 -0.43 ALA 1592

ARG 148 0.13 VAL 1573 -0.49 ALA 1592

ALA 1554 0.25 SER 1574 -0.38 ALA 1592

ASP 1582 0.22 THR 1575 -0.29 ALA 1592

ASP 1582 0.27 VAL 1576 -0.29 ALA 1592

ARG 148 0.16 ILE 1577 -0.28 ALA 1592

ARG 148 0.19 LYS 1578 -0.18 ALA 1592

ASP 1582 0.40 TYR 1579 -0.13 ALA 1592

ASP 1582 0.63 PHE 1580 -0.12 ALA 1592

PHE 1584 0.42 PRO 1581 -0.04 SER 1261

PRO 1473 0.65 ASP 1582 -0.18 VAL 1544

ALA 1460 0.35 LEU 1583 -0.18 ALA 1592

PRO 1581 0.42 PHE 1584 -0.41 TRP 1545

PRO 1581 0.39 PRO 1585 -0.63 VAL 1544

PRO 1581 0.36 GLU 1586 -0.71 ASP 1546

PRO 1581 0.26 PRO 1587 -0.79 ASP 1546

SER 1475 0.26 ARG 1588 -0.79 ARG 190

ALA 1591 0.28 ALA 1589 -0.87 ARG 190

SER 1475 0.21 VAL 1590 -1.00 PRO 192

ALA 1589 0.28 ALA 1591 -1.24 PRO 192

ALA 1589 0.27 ALA 1592 -1.48 PRO 192

ALA 1589 0.15 GLU 1593 -1.36 ALA 193

If you find results from this site helpful for your research, please cite one of our papers:

K. Suhre & Y.H. Sanejouand, ElNemo: a normal mode web-server for protein movement analysis and the generation of templates for molecular replacement. Nucleic Acids Research, 32, W610-W614, 2004.
K. Suhre & Y.H. Sanejouand, On the potential of normal mode analysis for solving difficult molecular replacement problems. Acta Cryst. D vol.60, p796-799, 2004 © International Union of Crystallography.

elNémo is maintained by Yves-Henri Sanejouand.
It was developed by Karsten Suhre.
Between 2003 and 2014, it was hosted by IGS (Marseille).
Between 2015 and 2025, it was hosted by US2B (Nantes).
Last modification: december 26th, 2025.

Should you encounter any unexpected behaviour, please let us know. elNémo has been hacked on november 27th. It has been moved away and runs again. **Still some additional cleaning from time to time** Sorry for the inconvenience.

*** ***

CA distance fluctuations for 260408115242648516

--- normal mode 16 ---

Should you encounter any unexpected behaviour,
please let us know.
elNémo has been hacked on november 27th.
It has been moved away and runs again.
Still some additional cleaning from time to time
Sorry for the inconvenience.

* *