CNRS Nantes University US2B US2B
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Should you encounter any unexpected behaviour,
please let us know.
 elNémo has been hacked on november 27th.
It has been moved away and runs again.
**Still some additional cleaning from time to time**
Sorry for the inconvenience.


***  extreme_12  ***

CA strain for 260409131037910024

---  normal mode 8  ---

This graph displays the distance variation between successive pairs of CA atoms in the two extreme conformations that were computed for this mode (DQMIN/DQMAX). Large distance variations can be an indicator for residue pairs that support the important strain in that particular normal mode movement. Note that residue pairs between chain breaks or at flexible ends of the protein may also exhibit large CA-CA distance variations. If more than one residues ae grouped together into a rigid block (NRBL>1), CA-CA distance variations between CA atoms in the same block will be very low.

This feature is still experimental and will be further developped in the future.

CA iCA i+1vari
LEU 171PRO 172 0.0000
PRO 172ARG 173 0.0002
ARG 173LEU 174 -0.0001
LEU 174PRO 175 -0.0349
PRO 175VAL 176 -0.0003
VAL 176PRO 177 -0.0000
PRO 177ALA 178 0.0000
ALA 178VAL 179 -0.0469
VAL 179LYS 180 -0.0005
LYS 180ASP 181 -0.0001
ASP 181THR 182 0.0001
THR 182VAL 183 -0.0354
VAL 183ASN 184 0.0002
ASN 184ARG 185 -0.0003
ARG 185TYR 186 0.0002
TYR 186LEU 187 -0.0129
LEU 187GLN 188 0.0001
GLN 188SER 189 0.0003
SER 189VAL 190 -0.0003
VAL 190ARG 191 -0.0015
ARG 191PRO 192 -0.0001
PRO 192LEU 193 0.0002
LEU 193MET 194 0.0002
MET 194LYS 195 0.0717
LYS 195GLU 196 -0.0004
GLU 196GLU 197 0.0001
GLU 197ASP 198 0.0002
ASP 198PHE 199 0.0031
PHE 199LYS 200 0.0002
LYS 200ARG 201 0.0001
ARG 201MET 202 0.0001
MET 202THR 203 -0.0140
THR 203ALA 204 -0.0001
ALA 204LEU 205 0.0000
LEU 205ALA 206 0.0000
ALA 206GLN 207 -0.0033
GLN 207ASP 208 -0.0004
ASP 208PHE 209 0.0001
PHE 209ALA 210 -0.0001
ALA 210VAL 211 0.0023
VAL 211GLY 212 0.0001
GLY 212LEU 213 -0.0001
LEU 213GLY 214 0.0001
GLY 214PRO 215 -0.0192
PRO 215ARG 216 0.0002
ARG 216LEU 217 0.0002
LEU 217GLN 218 0.0000
GLN 218TRP 219 -0.0046
TRP 219TYR 220 0.0001
TYR 220LEU 221 -0.0001
LEU 221LYS 222 -0.0001
LYS 222LEU 223 -0.0282
LEU 223LYS 224 0.0002
LYS 224SER 225 0.0001
SER 225TRP 226 -0.0001
TRP 226TRP 227 0.0061
TRP 227ALA 228 0.0002
ALA 228THR 229 0.0000
THR 229ASN 230 -0.0003
ASN 230TYR 231 -0.0027
TYR 231VAL 232 -0.0004
VAL 232SER 233 0.0003
SER 233ASP 234 -0.0001
ASP 234TRP 235 0.0077
TRP 235TRP 236 -0.0004
TRP 236GLU 237 -0.0001
GLU 237GLU 238 -0.0001
GLU 238TYR 239 -0.0550
TYR 239ILE 240 0.0004
ILE 240TYR 241 -0.0003
TYR 241LEU 242 0.0004
LEU 242ARG 243 -0.0415
ARG 243GLY 244 -0.0004
GLY 244ARG 245 0.0003
ARG 245GLY 246 0.0001
GLY 246PRO 247 -0.1933
PRO 247LEU 248 -0.0003
LEU 248MET 249 -0.0002
MET 249VAL 250 -0.0002
VAL 250ASN 251 -0.0697
ASN 251SER 252 -0.0003
SER 252ASN 253 0.0001
ASN 253TYR 254 0.0001
TYR 254TYR 255 -0.0002
TYR 255ALA 256 0.0001
ALA 256MET 257 -0.0002
MET 257ASP 258 0.0001
ASP 258LEU 259 0.0122
LEU 259LEU 260 0.0002
LEU 260TYR 261 -0.0000
TYR 261ILE 262 0.0002
ILE 262LEU 263 -0.0828
LEU 263PRO 264 -0.0001
PRO 264THR 265 -0.0004
THR 265HIS 266 -0.0001
HIS 266ILE 267 -0.0392
ILE 267GLN 268 0.0003
GLN 268ALA 269 0.0004
ALA 269ALA 270 -0.0002
ALA 270ARG 271 -0.0107
ARG 271ALA 272 -0.0004
ALA 272GLY 273 0.0002
GLY 273ASN 274 -0.0002
ASN 274ALA 275 0.0134
ALA 275ILE 276 -0.0001
ILE 276HIS 277 -0.0003
HIS 277ALA 278 -0.0001
ALA 278ILE 279 0.0150
ILE 279LEU 280 0.0001
LEU 280LEU 281 0.0002
LEU 281TYR 282 0.0001
TYR 282ARG 283 0.0011
ARG 283ARG 284 0.0002
ARG 284LYS 285 -0.0000
LYS 285LEU 286 -0.0001
LEU 286ASP 287 0.0145
ASP 287ARG 288 0.0003
ARG 288GLU 289 -0.0002
GLU 289GLU 290 0.0001
GLU 290ILE 291 -0.0194
ILE 291LYS 292 0.0001
LYS 292PRO 293 0.0001
PRO 293ILE 294 -0.0001
ILE 294ARG 295 -0.0241
ARG 295LEU 296 -0.0001
LEU 296LEU 297 -0.0002
LEU 297GLY 298 0.0000
GLY 298SER 299 0.0262
SER 299THR 300 -0.0000
THR 300ILE 301 0.0002
ILE 301PRO 302 -0.0001
PRO 302LEU 303 -0.0412
LEU 303CYS 304 0.0001
CYS 304SER 305 -0.0002
SER 305ALA 306 -0.0000
ALA 306GLN 307 -0.0581
GLN 307TRP 308 -0.0001
TRP 308GLU 309 0.0000
GLU 309ARG 310 0.0001
ARG 310MET 311 0.0574
MET 311PHE 312 0.0003
PHE 312ASN 313 -0.0000
ASN 313THR 314 -0.0000
THR 314SER 315 -0.1002
SER 315ARG 316 0.0001
ARG 316ILE 317 0.0001
ILE 317PRO 318 -0.0002
PRO 318GLY 319 -0.0059
GLY 319GLU 320 0.0000
GLU 320GLU 321 0.0004
GLU 321THR 322 -0.0000
THR 322ASP 323 0.0014
ASP 323THR 324 0.0003
THR 324ILE 325 -0.0004
ILE 325GLN 326 0.0003
GLN 326HIS 327 0.1083
HIS 327MET 328 0.0004
MET 328ARG 329 -0.0001
ARG 329ASP 330 -0.0000
ASP 330SER 331 0.0108
SER 331LYS 332 0.0001
LYS 332HIS 333 0.0002
HIS 333ILE 334 -0.0000
ILE 334VAL 335 -0.0163
VAL 335VAL 336 0.0001
VAL 336TYR 337 0.0004
TYR 337HIS 338 -0.0003
HIS 338ARG 339 -0.0011
ARG 339GLY 340 -0.0004
GLY 340ARG 341 -0.0001
ARG 341TYR 342 0.0002
TYR 342PHE 343 -0.0010
PHE 343LYS 344 -0.0002
LYS 344VAL 345 0.0002
VAL 345TRP 346 0.0001
TRP 346LEU 347 -0.0370
LEU 347TYR 348 -0.0002
TYR 348HIS 349 0.0004
HIS 349ASP 350 -0.0002
ASP 350GLY 351 -0.0202
GLY 351ARG 352 -0.0004
ARG 352LEU 353 0.0002
LEU 353LEU 354 0.0003
LEU 354LYS 355 0.0076
LYS 355PRO 356 0.0002
PRO 356ARG 357 -0.0001
ARG 357GLU 358 -0.0003
GLU 358MET 359 0.0148
MET 359GLU 360 -0.0001
GLU 360GLN 361 -0.0002
GLN 361GLN 362 0.0001
GLN 362MET 363 0.0097
MET 363GLN 364 0.0002
GLN 364ARG 365 -0.0000
ARG 365ILE 366 0.0001
ILE 366LEU 367 0.0009
LEU 367ASP 368 0.0001
ASP 368ASN 369 -0.0003
ASN 369THR 370 0.0003
THR 370SER 371 -0.0050
SER 371GLU 372 0.0003
GLU 372PRO 373 -0.0002
PRO 373GLN 374 0.0003
GLN 374PRO 375 -0.0015
PRO 375GLY 376 -0.0005
GLY 376GLU 377 -0.0001
GLU 377ALA 378 -0.0001
ALA 378ARG 379 -0.0071
ARG 379LEU 380 0.0001
LEU 380ALA 381 0.0001
ALA 381ALA 382 0.0002
ALA 382LEU 383 -0.0171
LEU 383THR 384 -0.0002
THR 384ALA 385 0.0003
ALA 385GLY 386 0.0001
GLY 386ASP 387 -0.0608
ASP 387ARG 388 0.0000
ARG 388VAL 389 -0.0001
VAL 389PRO 390 -0.0002
PRO 390TRP 391 -0.0023
TRP 391ALA 392 -0.0002
ALA 392ARG 393 -0.0005
ARG 393CYS 394 -0.0002
CYS 394ARG 395 -0.0043
ARG 395GLN 396 -0.0001
GLN 396ALA 397 0.0003
ALA 397TYR 398 0.0000
TYR 398PHE 399 -0.0083
PHE 399GLY 400 0.0003
GLY 400ARG 401 0.0001
ARG 401GLY 402 0.0004
GLY 402LYS 403 -0.0071
LYS 403ASN 404 0.0000
ASN 404LYS 405 -0.0003
LYS 405GLN 406 0.0004
GLN 406SER 407 -0.0007
SER 407LEU 408 0.0003
LEU 408ASP 409 -0.0000
ASP 409ALA 410 -0.0000
ALA 410VAL 411 0.0037
VAL 411GLU 412 -0.0001
GLU 412LYS 413 -0.0001
LYS 413ALA 414 -0.0001
ALA 414ALA 415 -0.0570
ALA 415PHE 416 0.0002
PHE 416PHE 417 -0.0003
PHE 417VAL 418 0.0003
VAL 418THR 419 -0.0053
THR 419LEU 420 -0.0001
LEU 420ASP 421 -0.0001
ASP 421GLU 422 0.0003
GLU 422THR 423 0.0247
THR 423GLU 424 -0.0002
GLU 424GLU 425 0.0002
GLU 425GLY 426 -0.0003
GLY 426TYR 427 -0.0508
TYR 427ARG 428 0.0002
ARG 428SER 429 -0.0002
SER 429GLU 430 -0.0000
GLU 430ASP 431 0.0057
ASP 431PRO 432 -0.0002
PRO 432ASP 433 -0.0002
ASP 433THR 434 0.0002
THR 434SER 435 -0.0080
SER 435MET 436 0.0001
MET 436ASP 437 0.0000
ASP 437SER 438 0.0002
SER 438TYR 439 0.0039
TYR 439ALA 440 -0.0002
ALA 440LYS 441 -0.0001
LYS 441SER 442 0.0001
SER 442LEU 443 -0.0094
LEU 443LEU 444 0.0001
LEU 444HIS 445 0.0001
HIS 445GLY 446 -0.0001
GLY 446ARG 447 0.0345
ARG 447CYS 448 0.0004
CYS 448TYR 449 0.0002
TYR 449ASP 450 0.0001
ASP 450ARG 451 -0.0127
ARG 451TRP 452 0.0002
TRP 452PHE 453 -0.0002
PHE 453ASP 454 -0.0000
ASP 454LYS 455 -0.0131
LYS 455SER 456 0.0002
SER 456PHE 457 -0.0002
PHE 457THR 458 -0.0001
THR 458PHE 459 -0.0013
PHE 459VAL 460 0.0001
VAL 460VAL 461 0.0001
VAL 461PHE 462 0.0003
PHE 462LYS 463 0.0091
LYS 463ASN 464 0.0000
ASN 464GLY 465 0.0002
GLY 465LYS 466 -0.0001
LYS 466MET 467 0.0092
MET 467GLY 468 -0.0003
GLY 468LEU 469 -0.0000
LEU 469ASN 470 -0.0002
ASN 470ALA 471 -0.0088
ALA 471GLU 472 -0.0001
GLU 472HIS 473 0.0001
HIS 473SER 474 -0.0002
SER 474TRP 475 -0.0034
TRP 475ALA 476 0.0001
ALA 476ASP 477 -0.0003
ASP 477ALA 478 -0.0000
ALA 478PRO 479 0.0132
PRO 479ILE 480 0.0000
ILE 480VAL 481 0.0003
VAL 481ALA 482 0.0000
ALA 482HIS 483 -0.0054
HIS 483LEU 484 -0.0002
LEU 484TRP 485 -0.0001
TRP 485GLU 486 0.0003
GLU 486TYR 487 -0.0232
TYR 487VAL 488 0.0001
VAL 488MET 489 -0.0000
MET 489SER 490 -0.0001
SER 490ILE 491 -0.0166
ILE 491ASP 492 0.0001
ASP 492SER 493 0.0002
SER 493LEU 494 -0.0001
LEU 494GLN 495 -0.0692
GLN 495LEU 496 0.0001
LEU 496GLY 497 0.0002
GLY 497TYR 498 -0.0003
TYR 498ALA 499 -0.0006
ALA 499GLU 500 0.0003
GLU 500ASP 501 -0.0001
ASP 501GLY 502 0.0003
GLY 502HIS 503 -0.0230
HIS 503CYS 504 -0.0002
CYS 504LYS 505 0.0001
LYS 505GLY 506 0.0001
GLY 506ASP 507 -0.0343
ASP 507ILE 508 -0.0001
ILE 508ASN 509 0.0001
ASN 509PRO 510 0.0000
PRO 510ASN 511 -0.0029
ASN 511ILE 512 -0.0001
ILE 512PRO 513 -0.0003
PRO 513TYR 514 0.0000
TYR 514PRO 515 0.0213
PRO 515THR 516 -0.0004
THR 516ARG 517 0.0002
ARG 517LEU 518 0.0002
LEU 518GLN 519 -0.0360
GLN 519TRP 520 -0.0000
TRP 520ASP 521 0.0001
ASP 521ILE 522 0.0002
ILE 522PRO 523 -0.0276
PRO 523GLY 524 -0.0003
GLY 524GLU 525 0.0001
GLU 525CYS 526 0.0003
CYS 526GLN 527 0.0120
GLN 527GLU 528 0.0000
GLU 528VAL 529 -0.0001
VAL 529ILE 530 0.0001
ILE 530GLU 531 0.0112
GLU 531THR 532 0.0001
THR 532SER 533 0.0004
SER 533LEU 534 -0.0004
LEU 534ASN 535 -0.0048
ASN 535THR 536 0.0000
THR 536ALA 537 0.0004
ALA 537ASN 538 -0.0001
ASN 538LEU 539 0.0709
LEU 539LEU 540 -0.0002
LEU 540ALA 541 -0.0004
ALA 541ASN 542 0.0001
ASN 542ASP 543 0.0416
ASP 543VAL 544 -0.0001
VAL 544ASP 545 0.0001
ASP 545PHE 546 0.0001
PHE 546HIS 547 0.0491
HIS 547SER 548 -0.0001
SER 548PHE 549 -0.0000
PHE 549PRO 550 -0.0002
PRO 550PHE 551 -0.0055
PHE 551VAL 552 -0.0005
VAL 552ALA 553 0.0002
ALA 553PHE 554 -0.0004
PHE 554GLY 555 -0.0052
GLY 555LYS 556 -0.0004
LYS 556GLY 557 -0.0001
GLY 557ILE 558 0.0002
ILE 558ILE 559 0.0188
ILE 559LYS 560 -0.0001
LYS 560LYS 561 -0.0001
LYS 561CYS 562 0.0003
CYS 562ARG 563 0.0764
ARG 563THR 564 -0.0002
THR 564SER 565 0.0002
SER 565PRO 566 0.0001
PRO 566ASP 567 -0.0033
ASP 567ALA 568 0.0002
ALA 568PHE 569 0.0000
PHE 569VAL 570 -0.0000
VAL 570GLN 571 -0.0332
GLN 571LEU 572 0.0002
LEU 572ALA 573 -0.0001
ALA 573LEU 574 -0.0000
LEU 574GLN 575 -0.0139
GLN 575LEU 576 -0.0002
LEU 576ALA 577 0.0001
ALA 577HIS 578 -0.0002
HIS 578TYR 579 0.0170
TYR 579LYS 580 0.0004
LYS 580ASP 581 -0.0002
ASP 581MET 582 0.0002
MET 582GLY 583 0.0194
GLY 583LYS 584 0.0002
LYS 584PHE 585 -0.0002
PHE 585CYS 586 0.0001
CYS 586LEU 587 -0.0857
LEU 587THR 588 0.0000
THR 588TYR 589 0.0002
TYR 589GLU 590 0.0001
GLU 590ALA 591 0.0051
ALA 591SER 592 0.0002
SER 592MET 593 0.0002
MET 593THR 594 0.0001
THR 594ARG 595 -0.0088
ARG 595LEU 596 -0.0001
LEU 596PHE 597 0.0001
PHE 597ARG 598 -0.0003
ARG 598GLU 599 -0.0492
GLU 599GLY 600 0.0002
GLY 600ARG 601 -0.0001
ARG 601THR 602 0.0001
THR 602GLU 603 0.0240
GLU 603THR 604 0.0003
THR 604VAL 605 0.0001
VAL 605ARG 606 -0.0004
ARG 606SER 607 -0.0086
SER 607CYS 608 0.0003
CYS 608THR 609 -0.0000
THR 609THR 610 -0.0002
THR 610GLU 611 -0.0454
GLU 611SER 612 -0.0002
SER 612CYS 613 -0.0002
CYS 613ASP 614 -0.0000
ASP 614PHE 615 -0.0293
PHE 615VAL 616 0.0002
VAL 616ARG 617 -0.0000
ARG 617ALA 618 -0.0002
ALA 618MET 619 -0.0174
MET 619VAL 620 -0.0001
VAL 620ASP 621 -0.0000
ASP 621PRO 622 0.0000
PRO 622ALA 623 0.0186
ALA 623GLN 624 -0.0001
GLN 624THR 625 0.0001
THR 625VAL 626 -0.0005
VAL 626GLU 627 -0.0067
GLU 627GLN 628 0.0001
GLN 628ARG 629 -0.0001
ARG 629LEU 630 0.0002
LEU 630LYS 631 0.0036
LYS 631LEU 632 -0.0001
LEU 632PHE 633 -0.0001
PHE 633LYS 634 -0.0002
LYS 634LEU 635 0.0105
LEU 635ALA 636 -0.0002
ALA 636SER 637 -0.0003
SER 637GLU 638 -0.0000
GLU 638LYS 639 0.0139
LYS 639HIS 640 -0.0004
HIS 640GLN 641 0.0005
GLN 641HIS 642 0.0001
HIS 642MET 643 0.0279
MET 643TYR 644 -0.0002
TYR 644ARG 645 -0.0003
ARG 645LEU 646 0.0001
LEU 646ALA 647 -0.0065
ALA 647MET 648 -0.0001
MET 648THR 649 -0.0001
THR 649GLY 650 -0.0001
GLY 650SER 651 -0.0551
SER 651GLY 652 -0.0001
GLY 652ILE 653 -0.0001
ILE 653ASP 654 -0.0002
ASP 654ARG 655 0.0226
ARG 655HIS 656 -0.0001
HIS 656LEU 657 0.0003
LEU 657PHE 658 -0.0003
PHE 658CYS 659 -0.0610
CYS 659LEU 660 -0.0001
LEU 660TYR 661 0.0002
TYR 661VAL 662 -0.0002
VAL 662VAL 663 0.0005
VAL 663SER 664 -0.0003
SER 664LYS 665 0.0002
LYS 665TYR 666 -0.0002
TYR 666LEU 667 -0.0026
LEU 667ALA 668 -0.0000
ALA 668VAL 669 0.0000
VAL 669GLU 670 0.0001
GLU 670SER 671 0.0028
SER 671PRO 672 -0.0001
PRO 672PHE 673 0.0001
PHE 673LEU 674 -0.0000
LEU 674LYS 675 -0.0163
LYS 675GLU 676 -0.0001
GLU 676VAL 677 0.0001
VAL 677LEU 678 -0.0001
LEU 678SER 679 -0.0927
SER 679GLU 680 -0.0000
GLU 680PRO 681 0.0004
PRO 681TRP 682 -0.0004
TRP 682ARG 683 -0.0602
ARG 683LEU 684 -0.0001
LEU 684SER 685 -0.0004
SER 685THR 686 -0.0000
THR 686SER 687 0.0094
SER 687GLN 688 0.0003
GLN 688THR 689 0.0000
THR 689PRO 690 -0.0002
PRO 690GLN 691 -0.0130
GLN 691GLN 692 0.0003
GLN 692GLN 693 0.0002
GLN 693VAL 694 -0.0003
VAL 694GLU 695 0.0218
GLU 695LEU 696 0.0000
LEU 696PHE 697 0.0001
PHE 697ASP 698 -0.0001
ASP 698LEU 699 -0.0281
LEU 699GLU 700 -0.0002
GLU 700ASN 701 0.0002
ASN 701ASN 702 0.0000
ASN 702PRO 703 0.0266
PRO 703GLU 704 0.0000
GLU 704TYR 705 -0.0002
TYR 705VAL 706 0.0001
VAL 706SER 707 0.0390
SER 707SER 708 -0.0001
SER 708GLY 709 0.0002
GLY 709GLY 710 0.0001
GLY 710GLY 711 0.0324
GLY 711PHE 712 0.0002
PHE 712GLY 713 0.0002
GLY 713PRO 714 -0.0002
PRO 714VAL 715 0.0103
VAL 715ALA 716 -0.0003
ALA 716ASP 717 -0.0001
ASP 717ASP 718 0.0000
ASP 718GLY 719 -0.0265
GLY 719TYR 720 -0.0000
TYR 720GLY 721 -0.0001
GLY 721VAL 722 0.0001
VAL 722SER 723 -0.0123
SER 723TYR 724 0.0001
TYR 724ILE 725 0.0003
ILE 725LEU 726 0.0001
LEU 726VAL 727 -0.0395
VAL 727GLY 728 -0.0000
GLY 728GLU 729 0.0003
GLU 729ASN 730 -0.0000
ASN 730LEU 731 0.0311
LEU 731ILE 732 0.0002
ILE 732ASN 733 0.0000
ASN 733PHE 734 -0.0001
PHE 734HIS 735 0.0249
HIS 735ILE 736 -0.0003
ILE 736SER 737 -0.0000
SER 737SER 738 0.0003
SER 738LYS 739 0.0266
LYS 739PHE 740 0.0000
PHE 740SER 741 -0.0001
SER 741CYS 742 -0.0001
CYS 742PRO 743 -0.0147
PRO 743GLU 744 0.0003
GLU 744THR 745 0.0001
THR 745ASP 746 -0.0003
ASP 746SER 747 -0.0243
SER 747HIS 748 -0.0005
HIS 748ARG 749 0.0001
ARG 749PHE 750 0.0000
PHE 750GLY 751 -0.0200
GLY 751ARG 752 0.0001
ARG 752HIS 753 -0.0002
HIS 753LEU 754 0.0000
LEU 754LYS 755 -0.0059
LYS 755GLU 756 -0.0000
GLU 756ALA 757 -0.0000
ALA 757MET 758 0.0003
MET 758THR 759 0.0132
THR 759ASP 760 0.0001
ASP 760ILE 761 -0.0000
ILE 761ILE 762 -0.0003
ILE 762THR 763 -0.0267
THR 763LEU 764 -0.0002
LEU 764PHE 765 -0.0003
PHE 765GLY 766 -0.0001
GLY 766LEU 767 -0.0436
LEU 767SER 768 -0.0001
SER 768SER 769 0.0001
SER 769ASN 770 0.0000
ASN 770SER 771 -0.0107
SER 771LYS 772 0.0002
LYS 772LYS 773 0.0006

If you find results from this site helpful for your research, please cite one of our papers:

elNémo is maintained by Yves-Henri Sanejouand.
It was developed by Karsten Suhre.
Between 2003 and 2014, it was hosted by IGS (Marseille).
Between 2015 and 2025, it was hosted by US2B (Nantes).
Last modification: december 26th, 2025.