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* LRRK2_7LI4_R1441C *

CA strain for 2605160929253032129

--- normal mode 9 ---

This graph displays the distance variation between successive pairs of CA atoms in the two extreme conformations that were computed for this mode (DQMIN/DQMAX). Large distance variations can be an indicator for residue pairs that support the important strain in that particular normal mode movement. Note that residue pairs between chain breaks or at flexible ends of the protein may also exhibit large CA-CA distance variations. If more than one residues ae grouped together into a rigid block (NRBL>1), CA-CA distance variations between CA atoms in the same block will be very low.

This feature is still experimental and will be further developped in the future.

CA i CA i+1 vari
GLY 558 ILE 559 -0.0003

ILE 559 GLN 560 -0.0001

GLN 560 LYS 561 0.0003

LYS 561 CYS 562 0.0000

CYS 562 GLY 563 0.0001

GLY 563 LEU 564 0.0002

LEU 564 LYS 565 -0.0000

LYS 565 VAL 566 0.0001

VAL 566 ILE 567 -0.0006

ILE 567 SER 568 -0.0002

SER 568 SER 569 0.0001

SER 569 ILE 570 0.0001

ILE 570 VAL 571 0.0001

VAL 571 HIS 572 0.0000

HIS 572 PHE 573 -0.0001

PHE 573 PRO 574 -0.0002

PRO 574 ASP 575 -0.0001

ASP 575 ALA 576 -0.0035

ALA 576 LEU 577 0.0004

LEU 577 GLY 584 0.0028

GLY 584 ALA 585 0.0002

ALA 585 MET 586 -0.0002

MET 586 ASP 587 0.0001

ASP 587 SER 588 0.0000

SER 588 VAL 589 0.0000

VAL 589 LEU 590 -0.0001

LEU 590 HIS 591 0.0002

HIS 591 THR 592 0.0003

THR 592 LEU 593 0.0051

LEU 593 GLN 594 -0.0001

GLN 594 MET 595 0.0001

MET 595 TYR 596 -0.0001

TYR 596 PRO 597 0.0002

PRO 597 ASP 598 -0.0003

ASP 598 ASP 599 0.0003

ASP 599 GLN 600 -0.0003

GLN 600 GLU 601 0.0002

GLU 601 ILE 602 0.0066

ILE 602 GLN 603 0.0001

GLN 603 CYS 604 0.0003

CYS 604 LEU 605 -0.0001

LEU 605 GLY 606 -0.0002

GLY 606 LEU 607 0.0003

LEU 607 SER 608 0.0001

SER 608 LEU 609 0.0000

LEU 609 ILE 610 -0.0002

ILE 610 GLY 611 -0.0100

GLY 611 TYR 612 -0.0000

TYR 612 GLY 624 0.0016

GLY 624 HIS 625 0.0003

HIS 625 LEU 626 0.0001

LEU 626 LEU 627 -0.0002

LEU 627 ALA 628 -0.0001

ALA 628 LYS 629 -0.0002

LYS 629 ILE 630 -0.0001

ILE 630 LEU 631 0.0003

LEU 631 VAL 632 0.0000

VAL 632 SER 633 -0.0039

SER 633 SER 634 -0.0000

SER 634 LEU 635 0.0001

LEU 635 TYR 636 0.0003

TYR 636 ARG 637 0.0000

ARG 637 PHE 638 -0.0002

PHE 638 LYS 639 -0.0002

LYS 639 ASP 640 -0.0001

ASP 640 VAL 641 0.0000

VAL 641 ALA 642 -0.0030

ALA 642 GLU 643 0.0002

GLU 643 ILE 644 0.0003

ILE 644 GLN 645 0.0001

GLN 645 THR 646 -0.0000

THR 646 LYS 647 -0.0000

LYS 647 GLY 648 -0.0000

GLY 648 PHE 649 -0.0000

PHE 649 GLN 650 -0.0001

GLN 650 THR 651 0.0043

THR 651 ILE 652 0.0002

ILE 652 LEU 653 -0.0003

LEU 653 ALA 654 -0.0002

ALA 654 ILE 655 -0.0000

ILE 655 LEU 656 0.0002

LEU 656 LYS 657 -0.0000

LYS 657 LEU 658 0.0000

LEU 658 SER 659 0.0001

SER 659 ALA 660 -0.0066

ALA 660 SER 661 0.0003

SER 661 PHE 662 -0.0006

PHE 662 SER 663 0.0004

SER 663 LYS 664 -0.0001

LYS 664 LEU 665 0.0001

LEU 665 LEU 666 -0.0001

LEU 666 VAL 667 0.0000

VAL 667 HIS 668 0.0002

HIS 668 HIS 669 -0.0069

HIS 669 SER 670 0.0002

SER 670 PHE 671 -0.0000

PHE 671 ASP 672 0.0003

ASP 672 LEU 673 0.0001

LEU 673 VAL 674 -0.0001

VAL 674 ILE 675 0.0000

ILE 675 PHE 676 0.0000

PHE 676 HIS 677 0.0001

HIS 677 GLN 678 -0.0024

GLN 678 MET 679 -0.0000

MET 679 SER 680 -0.0002

SER 680 SER 681 -0.0000

SER 681 ASN 682 -0.0004

ASN 682 ILE 683 0.0001

ILE 683 MET 684 -0.0001

MET 684 GLU 685 0.0002

GLU 685 GLN 686 -0.0001

GLN 686 LYS 687 -0.0007

LYS 687 ASP 688 0.0003

ASP 688 GLN 689 0.0001

GLN 689 GLN 690 -0.0000

GLN 690 PHE 691 0.0002

PHE 691 LEU 692 0.0000

LEU 692 ASN 693 0.0002

ASN 693 LEU 694 -0.0000

LEU 694 CYS 695 -0.0000

CYS 695 CYS 696 -0.0067

CYS 696 LYS 697 0.0002

LYS 697 CYS 698 0.0002

CYS 698 PHE 699 -0.0001

PHE 699 ALA 700 0.0002

ALA 700 LYS 701 -0.0002

LYS 701 VAL 702 -0.0003

VAL 702 ALA 703 0.0001

ALA 703 MET 704 -0.0003

MET 704 ASP 705 0.0067

ASP 705 ASP 706 0.0004

ASP 706 TYR 707 -0.0001

TYR 707 LEU 708 0.0003

LEU 708 LYS 709 0.0003

LYS 709 ASN 710 -0.0002

ASN 710 VAL 711 -0.0000

VAL 711 MET 712 0.0001

MET 712 LEU 713 -0.0001

LEU 713 GLU 714 -0.0040

GLU 714 ARG 715 -0.0002

ARG 715 ALA 716 -0.0001

ALA 716 CYS 717 0.0000

CYS 717 ASP 718 -0.0001

ASP 718 GLN 719 -0.0001

GLN 719 ASN 720 0.0000

ASN 720 ASN 721 -0.0001

ASN 721 SER 722 -0.0002

SER 722 ILE 723 0.0094

ILE 723 MET 724 -0.0001

MET 724 VAL 725 0.0002

VAL 725 GLU 726 0.0001

GLU 726 CYS 727 -0.0000

CYS 727 LEU 728 -0.0000

LEU 728 LEU 729 -0.0004

LEU 729 LEU 730 -0.0002

LEU 730 LEU 731 0.0002

LEU 731 GLY 732 0.0243

GLY 732 ALA 733 -0.0001

ALA 733 ASP 734 -0.0000

ASP 734 ALA 735 0.0003

ALA 735 ASN 736 0.0001

ASN 736 GLN 737 -0.0001

GLN 737 ALA 738 0.0000

ALA 738 LYS 739 -0.0001

LYS 739 GLU 740 -0.0003

GLU 740 GLY 741 -0.0017

GLY 741 SER 742 -0.0001

SER 742 SER 743 0.0003

SER 743 LEU 744 0.0000

LEU 744 ILE 745 0.0001

ILE 745 CYS 746 0.0005

CYS 746 GLN 747 0.0002

GLN 747 VAL 748 -0.0001

VAL 748 CYS 749 0.0002

CYS 749 GLU 750 -0.0033

GLU 750 LYS 751 -0.0004

LYS 751 GLU 752 -0.0001

GLU 752 SER 753 0.0000

SER 753 SER 754 0.0001

SER 754 PRO 755 0.0003

PRO 755 LYS 756 0.0002

LYS 756 LEU 757 -0.0000

LEU 757 VAL 758 0.0001

VAL 758 GLU 759 -0.0001

GLU 759 LEU 760 -0.0003

LEU 760 LEU 761 0.0001

LEU 761 LEU 762 0.0004

LEU 762 ASN 763 -0.0003

ASN 763 SER 764 -0.0001

SER 764 GLY 765 0.0003

GLY 765 SER 766 -0.0001

SER 766 ARG 767 -0.0004

ARG 767 GLU 768 -0.0213

GLU 768 GLN 769 0.0001

GLN 769 ASP 770 -0.0001

ASP 770 VAL 771 -0.0001

VAL 771 ARG 772 0.0000

ARG 772 LYS 773 -0.0001

LYS 773 ALA 774 0.0002

ALA 774 LEU 775 -0.0000

LEU 775 THR 776 -0.0001

THR 776 ILE 777 0.0043

ILE 777 SER 778 0.0000

SER 778 ILE 779 0.0001

ILE 779 GLY 780 0.0004

GLY 780 LYS 781 0.0001

LYS 781 GLY 782 0.0002

GLY 782 ASP 783 -0.0003

ASP 783 SER 784 0.0001

SER 784 GLN 785 -0.0003

GLN 785 ILE 786 0.0035

ILE 786 ILE 787 0.0002

ILE 787 SER 788 -0.0000

SER 788 LEU 789 -0.0005

LEU 789 LEU 790 0.0004

LEU 790 LEU 791 0.0003

LEU 791 ARG 792 -0.0002

ARG 792 ARG 793 -0.0000

ARG 793 LEU 794 0.0002

LEU 794 ALA 795 -0.0076

ALA 795 LEU 796 0.0001

LEU 796 ASP 797 0.0000

ASP 797 VAL 798 0.0001

VAL 798 ALA 799 0.0002

ALA 799 ASN 800 0.0000

ASN 800 ASN 801 0.0001

ASN 801 SER 802 -0.0001

SER 802 ILE 803 -0.0001

ILE 803 CYS 804 -0.0006

CYS 804 LEU 805 0.0000

LEU 805 GLY 806 0.0003

GLY 806 GLY 807 -0.0004

GLY 807 PHE 808 0.0003

PHE 808 CYS 809 0.0001

CYS 809 ILE 810 0.0005

ILE 810 GLY 811 0.0001

GLY 811 LYS 812 -0.0001

LYS 812 VAL 813 -0.0011

VAL 813 GLU 814 0.0001

GLU 814 PRO 815 -0.0002

PRO 815 SER 816 0.0001

SER 816 TRP 817 -0.0001

TRP 817 LEU 818 -0.0001

LEU 818 GLY 819 0.0001

GLY 819 PRO 820 -0.0002

PRO 820 LEU 821 0.0001

LEU 821 PHE 822 0.0007

PHE 822 PRO 823 0.0003

PRO 823 ASP 824 -0.0002

ASP 824 LYS 825 0.0001

LYS 825 THR 826 -0.0001

THR 826 SER 827 0.0002

SER 827 ASN 828 -0.0001

ASN 828 LEU 829 -0.0000

LEU 829 ARG 830 -0.0001

ARG 830 LYS 831 -0.0118

LYS 831 GLN 832 -0.0001

GLN 832 THR 833 0.0000

THR 833 ASN 834 0.0002

ASN 834 ILE 835 0.0001

ILE 835 ALA 836 -0.0004

ALA 836 SER 837 -0.0000

SER 837 THR 838 -0.0000

THR 838 LEU 839 0.0003

LEU 839 ALA 840 0.0029

ALA 840 ARG 841 0.0001

ARG 841 MET 842 -0.0003

MET 842 VAL 843 0.0002

VAL 843 ILE 844 0.0001

ILE 844 ARG 845 0.0001

ARG 845 TYR 846 -0.0001

TYR 846 GLN 847 -0.0002

GLN 847 MET 848 -0.0000

MET 848 LYS 849 -0.0044

LYS 849 SER 850 -0.0002

SER 850 ALA 851 -0.0003

ALA 851 VAL 852 0.0002

VAL 852 GLU 853 -0.0001

GLU 853 GLU 854 -0.0000

GLU 854 ARG 981 -0.0233

ARG 981 GLU 982 0.0002

GLU 982 TYR 983 0.0001

TYR 983 ILE 984 -0.0002

ILE 984 THR 985 -0.0003

THR 985 SER 986 -0.0000

SER 986 LEU 987 -0.0000

LEU 987 ASP 988 0.0001

ASP 988 LEU 989 -0.0003

LEU 989 SER 990 0.0070

SER 990 ALA 991 -0.0003

ALA 991 ASN 992 -0.0002

ASN 992 GLU 993 -0.0001

GLU 993 LEU 994 -0.0004

LEU 994 ARG 995 0.0001

ARG 995 ASP 996 -0.0002

ASP 996 ILE 997 0.0001

ILE 997 ASP 998 -0.0003

ASP 998 ALA 999 0.0071

ALA 999 LEU 1000 -0.0002

LEU 1000 SER 1001 -0.0004

SER 1001 GLN 1002 -0.0002

GLN 1002 LYS 1003 0.0000

LYS 1003 CYS 1004 0.0003

CYS 1004 CYS 1005 -0.0001

CYS 1005 ILE 1006 0.0002

ILE 1006 SER 1007 -0.0002

SER 1007 VAL 1008 0.0040

VAL 1008 HIS 1009 0.0002

HIS 1009 LEU 1010 -0.0001

LEU 1010 GLU 1011 0.0001

GLU 1011 HIS 1012 0.0004

HIS 1012 LEU 1013 -0.0001

LEU 1013 GLU 1014 -0.0001

GLU 1014 LYS 1015 0.0001

LYS 1015 LEU 1016 0.0002

LEU 1016 GLU 1017 0.0013

GLU 1017 LEU 1018 0.0005

LEU 1018 HIS 1019 0.0002

HIS 1019 GLN 1020 -0.0000

GLN 1020 ASN 1021 0.0002

ASN 1021 ALA 1022 -0.0001

ALA 1022 LEU 1023 0.0000

LEU 1023 THR 1024 0.0001

THR 1024 SER 1025 -0.0002

SER 1025 PHE 1026 0.0009

PHE 1026 PRO 1027 0.0003

PRO 1027 GLN 1028 -0.0000

GLN 1028 GLN 1029 -0.0001

GLN 1029 LEU 1030 -0.0002

LEU 1030 CYS 1031 -0.0002

CYS 1031 GLU 1032 -0.0000

GLU 1032 THR 1033 -0.0002

THR 1033 LEU 1034 0.0002

LEU 1034 LYS 1035 -0.0000

LYS 1035 SER 1036 0.0001

SER 1036 LEU 1037 -0.0004

LEU 1037 THR 1038 0.0001

THR 1038 HIS 1039 -0.0002

HIS 1039 LEU 1040 0.0002

LEU 1040 ASP 1041 -0.0002

ASP 1041 LEU 1042 0.0003

LEU 1042 HIS 1043 -0.0002

HIS 1043 SER 1044 -0.0039

SER 1044 ASN 1045 0.0002

ASN 1045 LYS 1046 -0.0001

LYS 1046 PHE 1047 -0.0001

PHE 1047 THR 1048 0.0000

THR 1048 SER 1049 0.0001

SER 1049 PHE 1050 0.0003

PHE 1050 PRO 1051 -0.0003

PRO 1051 SER 1052 0.0001

SER 1052 TYR 1053 0.0019

TYR 1053 LEU 1054 0.0003

LEU 1054 LEU 1055 -0.0001

LEU 1055 LYS 1056 0.0000

LYS 1056 MET 1057 -0.0001

MET 1057 SER 1058 -0.0001

SER 1058 CYS 1059 -0.0003

CYS 1059 ILE 1060 0.0002

ILE 1060 ALA 1061 0.0000

ALA 1061 ASN 1062 -0.0014

ASN 1062 LEU 1063 -0.0003

LEU 1063 ASP 1064 0.0001

ASP 1064 VAL 1065 0.0005

VAL 1065 SER 1066 -0.0000

SER 1066 ARG 1067 -0.0001

ARG 1067 ASN 1068 0.0003

ASN 1068 ASP 1069 0.0001

ASP 1069 ILE 1070 -0.0000

ILE 1070 GLY 1071 -0.0008

GLY 1071 PRO 1072 -0.0001

PRO 1072 SER 1073 -0.0000

SER 1073 VAL 1074 0.0001

VAL 1074 VAL 1075 0.0001

VAL 1075 LEU 1076 -0.0003

LEU 1076 ASP 1077 0.0003

ASP 1077 PRO 1078 -0.0000

PRO 1078 THR 1079 -0.0000

THR 1079 VAL 1080 -0.0008

VAL 1080 LYS 1081 -0.0002

LYS 1081 CYS 1082 -0.0000

CYS 1082 PRO 1083 0.0000

PRO 1083 THR 1084 0.0005

THR 1084 LEU 1085 -0.0002

LEU 1085 LYS 1086 0.0003

LYS 1086 GLN 1087 -0.0002

GLN 1087 PHE 1088 -0.0003

PHE 1088 ASN 1089 -0.0040

ASN 1089 LEU 1090 -0.0000

LEU 1090 SER 1091 -0.0000

SER 1091 TYR 1092 -0.0002

TYR 1092 ASN 1093 -0.0001

ASN 1093 GLN 1094 0.0000

GLN 1094 LEU 1095 -0.0000

LEU 1095 SER 1096 -0.0001

SER 1096 PHE 1097 -0.0003

PHE 1097 VAL 1098 -0.0009

VAL 1098 PRO 1099 -0.0002

PRO 1099 GLU 1100 -0.0001

GLU 1100 ASN 1101 -0.0004

ASN 1101 LEU 1102 0.0003

LEU 1102 THR 1103 0.0003

THR 1103 ASP 1104 -0.0003

ASP 1104 VAL 1105 -0.0003

VAL 1105 VAL 1106 -0.0002

VAL 1106 GLU 1107 0.0005

GLU 1107 LYS 1108 0.0004

LYS 1108 LEU 1109 0.0001

LEU 1109 GLU 1110 0.0003

GLU 1110 GLN 1111 -0.0003

GLN 1111 LEU 1112 0.0001

LEU 1112 ILE 1113 -0.0003

ILE 1113 LEU 1114 -0.0000

LEU 1114 GLU 1115 -0.0001

GLU 1115 GLY 1116 -0.0032

GLY 1116 ASN 1117 -0.0001

ASN 1117 LYS 1118 0.0001

LYS 1118 ILE 1119 -0.0001

ILE 1119 SER 1120 0.0003

SER 1120 GLY 1121 0.0001

GLY 1121 ILE 1122 -0.0000

ILE 1122 CYS 1123 -0.0000

CYS 1123 SER 1124 -0.0002

SER 1124 PRO 1125 -0.0025

PRO 1125 LEU 1126 -0.0001

LEU 1126 ARG 1127 0.0005

ARG 1127 LEU 1128 -0.0003

LEU 1128 LYS 1129 0.0002

LYS 1129 GLU 1130 -0.0000

GLU 1130 LEU 1131 0.0000

LEU 1131 LYS 1132 -0.0002

LYS 1132 ILE 1133 -0.0002

ILE 1133 LEU 1134 -0.0012

LEU 1134 ASN 1135 -0.0000

ASN 1135 LEU 1136 -0.0000

LEU 1136 SER 1137 0.0000

SER 1137 LYS 1138 0.0002

LYS 1138 ASN 1139 -0.0000

ASN 1139 HIS 1140 -0.0002

HIS 1140 ILE 1141 -0.0002

ILE 1141 SER 1142 -0.0002

SER 1142 SER 1143 -0.0012

SER 1143 LEU 1144 0.0000

LEU 1144 SER 1145 -0.0004

SER 1145 GLU 1146 0.0001

GLU 1146 ASN 1147 0.0002

ASN 1147 PHE 1148 -0.0002

PHE 1148 LEU 1149 0.0003

LEU 1149 GLU 1150 0.0000

GLU 1150 ALA 1151 0.0003

ALA 1151 CYS 1152 0.0006

CYS 1152 PRO 1153 0.0003

PRO 1153 LYS 1154 0.0005

LYS 1154 VAL 1155 0.0000

VAL 1155 GLU 1156 -0.0001

GLU 1156 SER 1157 -0.0002

SER 1157 PHE 1158 -0.0001

PHE 1158 SER 1159 0.0001

SER 1159 ALA 1160 -0.0003

ALA 1160 ARG 1161 -0.0003

ARG 1161 MET 1162 -0.0001

MET 1162 ASN 1163 0.0003

ASN 1163 PHE 1164 -0.0003

PHE 1164 LEU 1165 0.0003

LEU 1165 ALA 1166 -0.0002

ALA 1166 ALA 1167 0.0002

ALA 1167 MET 1168 -0.0002

MET 1168 PRO 1169 -0.0000

PRO 1169 PHE 1170 -0.0013

PHE 1170 LEU 1171 0.0004

LEU 1171 PRO 1172 0.0000

PRO 1172 PRO 1173 -0.0001

PRO 1173 SER 1174 0.0000

SER 1174 MET 1175 0.0002

MET 1175 THR 1176 -0.0001

THR 1176 ILE 1177 0.0000

ILE 1177 LEU 1178 0.0000

LEU 1178 LYS 1179 -0.0015

LYS 1179 LEU 1180 -0.0003

LEU 1180 SER 1181 -0.0002

SER 1181 GLN 1182 -0.0001

GLN 1182 ASN 1183 -0.0002

ASN 1183 LYS 1184 0.0004

LYS 1184 PHE 1185 -0.0001

PHE 1185 SER 1186 0.0001

SER 1186 CYS 1187 0.0002

CYS 1187 ILE 1188 -0.0011

ILE 1188 PRO 1189 -0.0002

PRO 1189 GLU 1190 0.0001

GLU 1190 ALA 1191 -0.0005

ALA 1191 ILE 1192 0.0001

ILE 1192 LEU 1193 0.0002

LEU 1193 ASN 1194 -0.0002

ASN 1194 LEU 1195 0.0000

LEU 1195 PRO 1196 0.0003

PRO 1196 HIS 1197 0.0010

HIS 1197 LEU 1198 0.0001

LEU 1198 ARG 1199 -0.0002

ARG 1199 SER 1200 -0.0003

SER 1200 LEU 1201 0.0000

LEU 1201 ASP 1202 0.0002

ASP 1202 MET 1203 -0.0000

MET 1203 SER 1204 0.0001

SER 1204 SER 1205 -0.0001

SER 1205 ASN 1206 -0.0007

ASN 1206 ASP 1207 0.0002

ASP 1207 ILE 1208 -0.0003

ILE 1208 GLN 1209 0.0000

GLN 1209 TYR 1210 0.0005

TYR 1210 LEU 1211 -0.0004

LEU 1211 PRO 1212 0.0001

PRO 1212 GLY 1213 -0.0002

GLY 1213 PRO 1214 -0.0001

PRO 1214 ALA 1215 -0.0003

ALA 1215 HIS 1216 0.0002

HIS 1216 TRP 1217 -0.0001

TRP 1217 LYS 1218 -0.0002

LYS 1218 SER 1219 -0.0002

SER 1219 LEU 1220 0.0002

LEU 1220 ASN 1221 0.0003

ASN 1221 LEU 1222 -0.0002

LEU 1222 ARG 1223 0.0000

ARG 1223 GLU 1224 -0.0002

GLU 1224 LEU 1225 0.0003

LEU 1225 LEU 1226 -0.0000

LEU 1226 PHE 1227 -0.0001

PHE 1227 SER 1228 0.0000

SER 1228 HIS 1229 -0.0002

HIS 1229 ASN 1230 0.0003

ASN 1230 GLN 1231 -0.0002

GLN 1231 ILE 1232 0.0002

ILE 1232 SER 1233 0.0029

SER 1233 ILE 1234 -0.0003

ILE 1234 LEU 1235 0.0001

LEU 1235 ASP 1236 -0.0003

ASP 1236 LEU 1237 -0.0000

LEU 1237 SER 1238 -0.0000

SER 1238 GLU 1239 -0.0004

GLU 1239 LYS 1240 0.0005

LYS 1240 ALA 1241 0.0000

ALA 1241 TYR 1242 -0.0031

TYR 1242 LEU 1243 0.0003

LEU 1243 TRP 1244 -0.0001

TRP 1244 SER 1245 0.0002

SER 1245 ARG 1246 0.0002

ARG 1246 VAL 1247 -0.0002

VAL 1247 GLU 1248 -0.0002

GLU 1248 LYS 1249 0.0003

LYS 1249 LEU 1250 -0.0003

LEU 1250 HIS 1251 0.0005

HIS 1251 LEU 1252 0.0001

LEU 1252 SER 1253 -0.0001

SER 1253 HIS 1254 0.0004

HIS 1254 ASN 1255 -0.0002

ASN 1255 LYS 1256 0.0001

LYS 1256 LEU 1257 -0.0001

LEU 1257 LYS 1258 0.0001

LYS 1258 GLU 1259 -0.0003

GLU 1259 ILE 1260 -0.0043

ILE 1260 PRO 1261 -0.0002

PRO 1261 PRO 1262 0.0001

PRO 1262 GLU 1263 -0.0001

GLU 1263 ILE 1264 -0.0001

ILE 1264 GLY 1265 0.0001

GLY 1265 CYS 1266 -0.0001

CYS 1266 LEU 1267 0.0003

LEU 1267 GLU 1268 -0.0001

GLU 1268 ASN 1269 -0.0029

ASN 1269 LEU 1270 0.0001

LEU 1270 THR 1271 -0.0001

THR 1271 SER 1272 0.0000

SER 1272 LEU 1273 -0.0001

LEU 1273 ASP 1274 0.0004

ASP 1274 VAL 1275 -0.0001

VAL 1275 SER 1276 -0.0002

SER 1276 TYR 1277 0.0002

TYR 1277 ASN 1278 0.0070

ASN 1278 LEU 1279 -0.0004

LEU 1279 GLU 1280 0.0001

GLU 1280 LEU 1281 -0.0001

LEU 1281 ARG 1282 -0.0002

ARG 1282 SER 1283 -0.0001

SER 1283 PHE 1284 -0.0001

PHE 1284 PRO 1285 -0.0001

PRO 1285 ASN 1286 -0.0005

ASN 1286 GLU 1287 -0.0004

GLU 1287 MET 1288 -0.0000

MET 1288 GLY 1289 -0.0002

GLY 1289 LYS 1290 -0.0002

LYS 1290 LEU 1291 -0.0000

LEU 1291 SER 1292 -0.0004

SER 1292 LYS 1293 0.0003

LYS 1293 ILE 1294 -0.0000

ILE 1294 TRP 1295 0.0000

TRP 1295 ASP 1296 -0.0066

ASP 1296 LEU 1297 0.0003

LEU 1297 PRO 1298 -0.0001

PRO 1298 LEU 1299 -0.0004

LEU 1299 ASP 1300 -0.0001

ASP 1300 GLU 1301 0.0000

GLU 1301 LEU 1302 0.0004

LEU 1302 HIS 1303 -0.0001

HIS 1303 LEU 1304 0.0000

LEU 1304 ASN 1305 0.0133

ASN 1305 PHE 1306 -0.0002

PHE 1306 ASP 1307 0.0001

ASP 1307 PHE 1308 -0.0001

PHE 1308 LYS 1309 -0.0001

LYS 1309 HIS 1310 -0.0002

HIS 1310 ILE 1311 0.0001

ILE 1311 GLY 1312 0.0000

GLY 1312 CYS 1313 0.0003

CYS 1313 LYS 1314 -0.0244

LYS 1314 ALA 1315 -0.0002

ALA 1315 LYS 1316 0.0003

LYS 1316 ASP 1317 -0.0003

ASP 1317 ILE 1318 -0.0003

ILE 1318 ILE 1319 -0.0004

ILE 1319 ARG 1320 0.0002

ARG 1320 PHE 1321 -0.0003

PHE 1321 LEU 1322 -0.0001

LEU 1322 GLN 1323 0.0019

GLN 1323 GLN 1324 0.0002

GLN 1324 ARG 1325 -0.0002

ARG 1325 LEU 1326 -0.0002

LEU 1326 LYS 1327 0.0001

LYS 1327 LYS 1328 -0.0003

LYS 1328 ALA 1329 0.0004

ALA 1329 VAL 1330 -0.0002

VAL 1330 PRO 1331 0.0001

PRO 1331 TYR 1332 0.0039

TYR 1332 ASN 1333 0.0001

ASN 1333 ARG 1334 -0.0000

ARG 1334 MET 1335 0.0002

MET 1335 LYS 1336 -0.0004

LYS 1336 LEU 1337 -0.0001

LEU 1337 MET 1338 -0.0001

MET 1338 ILE 1339 0.0002

ILE 1339 VAL 1340 -0.0005

VAL 1340 GLY 1341 -0.0046

GLY 1341 ASN 1342 -0.0002

ASN 1342 THR 1343 -0.0000

THR 1343 GLY 1344 -0.0004

GLY 1344 SER 1345 0.0002

SER 1345 GLY 1346 -0.0003

GLY 1346 LYS 1347 -0.0001

LYS 1347 THR 1348 -0.0000

THR 1348 THR 1349 0.0000

THR 1349 LEU 1350 -0.0008

LEU 1350 LEU 1351 -0.0001

LEU 1351 GLN 1352 0.0002

GLN 1352 GLN 1353 -0.0001

GLN 1353 LEU 1354 -0.0001

LEU 1354 MET 1355 0.0001

MET 1355 LYS 1356 -0.0002

LYS 1356 THR 1357 0.0002

THR 1357 LYS 1358 0.0001

LYS 1358 LYS 1359 0.0010

LYS 1359 SER 1360 -0.0003

SER 1360 ASP 1361 -0.0004

ASP 1361 LEU 1362 -0.0000

LEU 1362 GLY 1363 0.0000

GLY 1363 MET 1364 -0.0001

MET 1364 GLN 1365 0.0001

GLN 1365 SER 1366 0.0000

SER 1366 ALA 1367 0.0001

ALA 1367 THR 1368 -0.0009

THR 1368 VAL 1369 0.0003

VAL 1369 GLY 1370 0.0003

GLY 1370 ILE 1371 0.0001

ILE 1371 ASP 1372 0.0002

ASP 1372 VAL 1373 0.0002

VAL 1373 LYS 1374 -0.0002

LYS 1374 ASP 1375 -0.0001

ASP 1375 TRP 1376 -0.0001

TRP 1376 PRO 1377 -0.0010

PRO 1377 ILE 1378 -0.0002

ILE 1378 GLN 1379 -0.0001

GLN 1379 ILE 1380 0.0001

ILE 1380 ARG 1381 -0.0001

ARG 1381 ASP 1382 0.0002

ASP 1382 LYS 1383 0.0001

LYS 1383 ARG 1384 -0.0002

ARG 1384 LYS 1385 -0.0002

LYS 1385 ARG 1386 -0.0013

ARG 1386 ASP 1387 0.0002

ASP 1387 LEU 1388 -0.0001

LEU 1388 VAL 1389 0.0001

VAL 1389 LEU 1390 -0.0002

LEU 1390 ASN 1391 -0.0000

ASN 1391 VAL 1392 -0.0000

VAL 1392 TRP 1393 0.0002

TRP 1393 ASP 1394 -0.0002

ASP 1394 PHE 1395 0.0005

PHE 1395 ALA 1396 0.0003

ALA 1396 GLY 1397 0.0003

GLY 1397 ARG 1398 -0.0001

ARG 1398 GLU 1399 0.0002

GLU 1399 GLU 1400 -0.0002

GLU 1400 PHE 1401 0.0003

PHE 1401 TYR 1402 0.0002

TYR 1402 SER 1403 0.0003

SER 1403 THR 1404 0.0017

THR 1404 HIS 1405 0.0001

HIS 1405 PRO 1406 -0.0002

PRO 1406 HIS 1407 -0.0000

HIS 1407 PHE 1408 -0.0003

PHE 1408 MET 1409 0.0002

MET 1409 THR 1410 0.0001

THR 1410 GLN 1411 -0.0001

GLN 1411 ARG 1412 -0.0003

ARG 1412 ALA 1413 -0.0055

ALA 1413 LEU 1414 -0.0005

LEU 1414 TYR 1415 -0.0001

TYR 1415 LEU 1416 0.0003

LEU 1416 ALA 1417 0.0000

ALA 1417 VAL 1418 0.0001

VAL 1418 TYR 1419 -0.0002

TYR 1419 ASP 1420 0.0002

ASP 1420 LEU 1421 0.0002

LEU 1421 SER 1422 -0.0039

SER 1422 LYS 1423 -0.0002

LYS 1423 GLY 1424 0.0001

GLY 1424 GLN 1425 0.0001

GLN 1425 ALA 1426 -0.0004

ALA 1426 GLU 1427 -0.0003

GLU 1427 VAL 1428 0.0003

VAL 1428 ASP 1429 0.0003

ASP 1429 ALA 1430 -0.0002

ALA 1430 MET 1431 -0.0002

MET 1431 LYS 1432 -0.0004

LYS 1432 PRO 1433 -0.0002

PRO 1433 TRP 1434 -0.0001

TRP 1434 LEU 1435 -0.0000

LEU 1435 PHE 1436 0.0002

PHE 1436 ASN 1437 0.0001

ASN 1437 ILE 1438 -0.0002

ILE 1438 LYS 1439 -0.0005

LYS 1439 ALA 1440 0.0014

ALA 1440 CYS 1441 -0.0002

CYS 1441 ALA 1442 0.0001

ALA 1442 SER 1443 -0.0002

SER 1443 SER 1444 0.0002

SER 1444 SER 1445 -0.0000

SER 1445 PRO 1446 -0.0002

PRO 1446 VAL 1447 -0.0005

VAL 1447 ILE 1448 0.0003

ILE 1448 LEU 1449 -0.0014

LEU 1449 VAL 1450 0.0000

VAL 1450 GLY 1451 -0.0000

GLY 1451 THR 1452 -0.0001

THR 1452 HIS 1453 -0.0005

HIS 1453 LEU 1454 0.0001

LEU 1454 ASP 1455 -0.0001

ASP 1455 VAL 1456 0.0001

VAL 1456 SER 1457 0.0001

SER 1457 LYS 1463 0.0033

LYS 1463 ALA 1464 0.0000

ALA 1464 CYS 1465 0.0002

CYS 1465 MET 1466 0.0003

MET 1466 SER 1467 0.0002

SER 1467 LYS 1468 -0.0003

LYS 1468 ILE 1469 -0.0001

ILE 1469 THR 1470 0.0002

THR 1470 LYS 1471 0.0001

LYS 1471 GLU 1472 0.0008

GLU 1472 LEU 1473 -0.0001

LEU 1473 LEU 1474 -0.0002

LEU 1474 ASN 1475 0.0001

ASN 1475 LYS 1476 -0.0002

LYS 1476 ARG 1477 -0.0001

ARG 1477 GLY 1478 0.0002

GLY 1478 PHE 1479 0.0001

PHE 1479 PRO 1480 0.0002

PRO 1480 ALA 1481 -0.0001

ALA 1481 ILE 1482 -0.0000

ILE 1482 ARG 1483 -0.0001

ARG 1483 ASP 1484 -0.0002

ASP 1484 TYR 1485 0.0002

TYR 1485 HIS 1486 -0.0003

HIS 1486 PHE 1487 -0.0003

PHE 1487 VAL 1488 0.0003

VAL 1488 ASN 1489 0.0002

ASN 1489 ALA 1490 -0.0007

ALA 1490 THR 1491 -0.0002

THR 1491 GLU 1492 -0.0003

GLU 1492 GLU 1493 -0.0001

GLU 1493 SER 1494 0.0002

SER 1494 ASP 1495 0.0002

ASP 1495 ALA 1496 -0.0001

ALA 1496 LEU 1497 0.0001

LEU 1497 ALA 1498 0.0002

ALA 1498 LYS 1499 0.0014

LYS 1499 LEU 1500 0.0003

LEU 1500 ARG 1501 -0.0001

ARG 1501 LYS 1502 -0.0002

LYS 1502 THR 1503 0.0003

THR 1503 ILE 1504 0.0001

ILE 1504 ILE 1505 -0.0003

ILE 1505 ASN 1506 0.0004

ASN 1506 GLU 1507 -0.0005

GLU 1507 SER 1508 -0.0036

SER 1508 LEU 1509 0.0004

LEU 1509 ASN 1510 -0.0002

ASN 1510 PHE 1511 -0.0006

PHE 1511 LYS 1512 0.0001

LYS 1512 ILE 1513 -0.0001

ILE 1513 ARG 1514 -0.0003

ARG 1514 ASP 1515 0.0003

ASP 1515 GLN 1516 -0.0004

GLN 1516 LEU 1517 0.0042

LEU 1517 VAL 1518 0.0004

VAL 1518 VAL 1519 -0.0002

VAL 1519 GLY 1520 -0.0000

GLY 1520 GLN 1521 -0.0001

GLN 1521 LEU 1522 -0.0001

LEU 1522 ILE 1523 -0.0002

ILE 1523 PRO 1524 0.0002

PRO 1524 ASP 1525 -0.0001

ASP 1525 CYS 1526 -0.0028

CYS 1526 TYR 1527 -0.0001

TYR 1527 VAL 1528 0.0003

VAL 1528 GLU 1529 -0.0002

GLU 1529 LEU 1530 0.0004

LEU 1530 GLU 1531 -0.0000

GLU 1531 LYS 1532 -0.0003

LYS 1532 ILE 1533 0.0000

ILE 1533 ILE 1534 -0.0001

ILE 1534 LEU 1535 -0.0051

LEU 1535 SER 1536 0.0003

SER 1536 GLU 1537 0.0003

GLU 1537 ARG 1538 0.0001

ARG 1538 LYS 1539 -0.0003

LYS 1539 ASN 1540 0.0003

ASN 1540 VAL 1541 -0.0002

VAL 1541 PRO 1542 -0.0001

PRO 1542 ILE 1543 0.0001

ILE 1543 GLU 1544 0.0056

GLU 1544 PHE 1545 -0.0001

PHE 1545 PRO 1546 0.0002

PRO 1546 VAL 1547 0.0000

VAL 1547 ILE 1548 -0.0001

ILE 1548 ASP 1549 -0.0001

ASP 1549 ARG 1550 -0.0000

ARG 1550 LYS 1551 -0.0001

LYS 1551 ARG 1552 -0.0002

ARG 1552 LEU 1553 0.0008

LEU 1553 LEU 1554 -0.0002

LEU 1554 GLN 1555 -0.0002

GLN 1555 LEU 1556 0.0001

LEU 1556 VAL 1557 -0.0002

VAL 1557 ARG 1558 -0.0000

ARG 1558 GLU 1559 0.0001

GLU 1559 ASN 1560 0.0000

ASN 1560 GLN 1561 -0.0000

GLN 1561 LEU 1562 -0.0081

LEU 1562 GLN 1563 0.0000

GLN 1563 LEU 1564 0.0002

LEU 1564 ASP 1565 0.0000

ASP 1565 GLU 1566 -0.0002

GLU 1566 ASN 1567 -0.0003

ASN 1567 GLU 1568 0.0001

GLU 1568 LEU 1569 -0.0004

LEU 1569 PRO 1570 -0.0000

PRO 1570 HIS 1571 -0.0122

HIS 1571 ALA 1572 0.0000

ALA 1572 VAL 1573 -0.0001

VAL 1573 HIS 1574 -0.0001

HIS 1574 PHE 1575 -0.0001

PHE 1575 LEU 1576 0.0002

LEU 1576 ASN 1577 -0.0001

ASN 1577 GLU 1578 0.0000

GLU 1578 SER 1579 0.0002

SER 1579 GLY 1580 -0.0009

GLY 1580 VAL 1581 0.0000

VAL 1581 LEU 1582 0.0001

LEU 1582 LEU 1583 -0.0001

LEU 1583 HIS 1584 -0.0001

HIS 1584 PHE 1585 0.0003

PHE 1585 GLN 1586 -0.0001

GLN 1586 ASP 1587 -0.0004

ASP 1587 PRO 1588 -0.0002

PRO 1588 ALA 1589 -0.0040

ALA 1589 LEU 1590 -0.0003

LEU 1590 GLN 1591 0.0002

GLN 1591 LEU 1592 0.0002

LEU 1592 SER 1593 -0.0001

SER 1593 ASP 1594 0.0003

ASP 1594 LEU 1595 -0.0002

LEU 1595 TYR 1596 0.0000

TYR 1596 PHE 1597 0.0002

PHE 1597 VAL 1598 -0.0021

VAL 1598 GLU 1599 0.0000

GLU 1599 PRO 1600 0.0003

PRO 1600 LYS 1601 -0.0002

LYS 1601 TRP 1602 0.0000

TRP 1602 LEU 1603 0.0000

LEU 1603 CYS 1604 -0.0001

CYS 1604 LYS 1605 0.0003

LYS 1605 ILE 1606 -0.0002

ILE 1606 MET 1607 0.0009

MET 1607 ALA 1608 0.0001

ALA 1608 GLN 1609 0.0001

GLN 1609 ILE 1610 0.0003

ILE 1610 LEU 1611 0.0001

LEU 1611 THR 1612 -0.0003

THR 1612 VAL 1613 0.0002

VAL 1613 LYS 1614 -0.0003

LYS 1614 VAL 1615 0.0001

VAL 1615 GLU 1616 0.0016

GLU 1616 GLY 1617 0.0002

GLY 1617 CYS 1618 0.0002

CYS 1618 PRO 1619 0.0001

PRO 1619 LYS 1620 -0.0001

LYS 1620 HIS 1621 0.0001

HIS 1621 PRO 1622 -0.0004

PRO 1622 LYS 1623 0.0002

LYS 1623 GLY 1624 0.0002

GLY 1624 ILE 1625 0.0018

ILE 1625 ILE 1626 0.0001

ILE 1626 SER 1627 -0.0000

SER 1627 ARG 1628 -0.0006

ARG 1628 ARG 1629 -0.0001

ARG 1629 ASP 1630 0.0003

ASP 1630 PRO 1642 0.0026

PRO 1642 LYS 1643 0.0003

LYS 1643 ASN 1644 -0.0000

ASN 1644 TYR 1645 0.0001

TYR 1645 MET 1646 -0.0002

MET 1646 THR 1647 -0.0000

THR 1647 GLN 1648 -0.0002

GLN 1648 TYR 1649 0.0003

TYR 1649 PHE 1650 -0.0002

PHE 1650 LYS 1651 -0.0001

LYS 1651 LEU 1652 -0.0003

LEU 1652 LEU 1653 0.0002

LEU 1653 GLU 1654 -0.0001

GLU 1654 LYS 1655 0.0003

LYS 1655 PHE 1656 0.0002

PHE 1656 GLN 1657 0.0004

GLN 1657 ILE 1658 -0.0000

ILE 1658 ALA 1659 -0.0001

ALA 1659 LEU 1668 0.0121

LEU 1668 VAL 1669 0.0004

VAL 1669 PRO 1670 -0.0003

PRO 1670 SER 1671 0.0001

SER 1671 SER 1672 0.0002

SER 1672 LEU 1673 -0.0000

LEU 1673 SER 1674 0.0000

SER 1674 ASP 1675 -0.0002

ASP 1675 HIS 1676 0.0000

HIS 1676 ARG 1677 -0.0000

ARG 1677 PRO 1678 -0.0004

PRO 1678 VAL 1679 -0.0002

VAL 1679 ILE 1680 -0.0002

ILE 1680 GLU 1681 -0.0001

GLU 1681 LEU 1682 0.0002

LEU 1682 PRO 1683 -0.0002

PRO 1683 HIS 1684 0.0001

HIS 1684 CYS 1685 0.0001

CYS 1685 GLU 1686 0.0088

GLU 1686 ASN 1687 0.0002

ASN 1687 SER 1688 -0.0000

SER 1688 GLU 1689 -0.0001

GLU 1689 ILE 1690 -0.0002

ILE 1690 ILE 1691 0.0001

ILE 1691 ILE 1692 -0.0002

ILE 1692 ARG 1693 0.0004

ARG 1693 LEU 1694 -0.0003

LEU 1694 TYR 1695 0.0002

TYR 1695 GLU 1696 0.0003

GLU 1696 MET 1697 0.0002

MET 1697 PRO 1698 -0.0002

PRO 1698 TYR 1699 -0.0002

TYR 1699 PHE 1700 -0.0002

PHE 1700 PRO 1701 0.0003

PRO 1701 MET 1702 -0.0004

MET 1702 GLY 1703 -0.0002

GLY 1703 PHE 1704 0.0003

PHE 1704 TRP 1705 -0.0001

TRP 1705 SER 1706 0.0004

SER 1706 ARG 1707 0.0004

ARG 1707 LEU 1708 0.0001

LEU 1708 ILE 1709 0.0000

ILE 1709 ASN 1710 0.0001

ASN 1710 ARG 1711 0.0001

ARG 1711 LEU 1712 0.0001

LEU 1712 LEU 1713 0.0021

LEU 1713 GLU 1714 -0.0001

GLU 1714 ILE 1715 -0.0002

ILE 1715 SER 1716 0.0001

SER 1716 PRO 1717 -0.0001

PRO 1717 TYR 1718 0.0001

TYR 1718 MET 1719 0.0003

MET 1719 LEU 1720 -0.0001

LEU 1720 ALA 1726 -0.0051

ALA 1726 LEU 1727 0.0001

LEU 1727 ARG 1728 -0.0001

ARG 1728 PRO 1729 0.0000

PRO 1729 ASN 1730 0.0001

ASN 1730 ARG 1731 -0.0001

ARG 1731 MET 1732 -0.0001

MET 1732 TYR 1733 0.0005

TYR 1733 TRP 1734 0.0002

TRP 1734 ARG 1735 -0.0019

ARG 1735 GLN 1736 -0.0001

GLN 1736 GLY 1737 -0.0000

GLY 1737 ILE 1738 0.0001

ILE 1738 TYR 1739 -0.0003

TYR 1739 LEU 1740 -0.0001

LEU 1740 ASN 1741 0.0003

ASN 1741 TRP 1742 0.0002

TRP 1742 SER 1743 -0.0003

SER 1743 PRO 1744 0.0020

PRO 1744 GLU 1745 -0.0003

GLU 1745 ALA 1746 0.0004

ALA 1746 TYR 1747 -0.0001

TYR 1747 CYS 1748 -0.0001

CYS 1748 LEU 1749 -0.0001

LEU 1749 VAL 1750 -0.0000

VAL 1750 GLY 1751 -0.0002

GLY 1751 SER 1752 -0.0001

SER 1752 GLU 1753 0.0043

GLU 1753 VAL 1754 -0.0002

VAL 1754 LEU 1755 0.0003

LEU 1755 ASP 1756 -0.0003

ASP 1756 ASN 1757 0.0003

ASN 1757 HIS 1758 -0.0004

HIS 1758 PRO 1759 0.0002

PRO 1759 GLU 1760 0.0002

GLU 1760 SER 1761 0.0003

SER 1761 PHE 1762 0.0018

PHE 1762 LEU 1763 -0.0001

LEU 1763 LYS 1764 -0.0001

LYS 1764 ILE 1765 -0.0003

ILE 1765 THR 1766 0.0004

THR 1766 VAL 1767 -0.0001

VAL 1767 PRO 1768 -0.0001

PRO 1768 SER 1769 -0.0001

SER 1769 CYS 1770 -0.0002

CYS 1770 ARG 1771 0.0037

ARG 1771 LYS 1772 -0.0001

LYS 1772 GLY 1773 -0.0000

GLY 1773 CYS 1774 -0.0004

CYS 1774 ILE 1775 0.0003

ILE 1775 LEU 1776 -0.0001

LEU 1776 LEU 1777 -0.0003

LEU 1777 GLY 1778 0.0000

GLY 1778 GLN 1779 -0.0003

GLN 1779 VAL 1780 0.0009

VAL 1780 VAL 1781 0.0001

VAL 1781 ASP 1782 0.0004

ASP 1782 HIS 1783 -0.0000

HIS 1783 ILE 1784 -0.0002

ILE 1784 ASP 1785 -0.0001

ASP 1785 SER 1786 -0.0001

SER 1786 LEU 1787 -0.0001

LEU 1787 MET 1788 0.0000

MET 1788 GLU 1789 -0.0009

GLU 1789 GLU 1790 0.0001

GLU 1790 TRP 1791 -0.0002

TRP 1791 PHE 1792 0.0002

PHE 1792 PRO 1793 -0.0001

PRO 1793 GLY 1794 0.0001

GLY 1794 LEU 1795 -0.0002

LEU 1795 LEU 1796 -0.0001

LEU 1796 GLU 1797 0.0006

GLU 1797 ILE 1798 -0.0002

ILE 1798 ASP 1799 -0.0002

ASP 1799 ILE 1800 -0.0002

ILE 1800 CYS 1801 0.0001

CYS 1801 GLY 1802 0.0002

GLY 1802 GLU 1803 0.0001

GLU 1803 GLY 1804 0.0002

GLY 1804 GLU 1805 -0.0001

GLU 1805 THR 1806 -0.0001

THR 1806 LEU 1807 -0.0038

LEU 1807 LEU 1808 0.0001

LEU 1808 LYS 1809 0.0000

LYS 1809 LYS 1810 -0.0001

LYS 1810 TRP 1811 0.0001

TRP 1811 ALA 1812 0.0001

ALA 1812 LEU 1813 0.0005

LEU 1813 TYR 1814 -0.0000

TYR 1814 SER 1815 0.0002

SER 1815 PHE 1816 -0.0040

PHE 1816 ASN 1817 0.0003

ASN 1817 ASP 1818 0.0002

ASP 1818 GLY 1819 -0.0000

GLY 1819 GLU 1820 0.0001

GLU 1820 GLU 1821 -0.0002

GLU 1821 HIS 1822 -0.0000

HIS 1822 GLN 1823 -0.0003

GLN 1823 LYS 1824 0.0002

LYS 1824 ILE 1825 -0.0006

ILE 1825 LEU 1826 -0.0001

LEU 1826 LEU 1827 -0.0001

LEU 1827 ASP 1828 -0.0000

ASP 1828 ASP 1829 -0.0001

ASP 1829 LEU 1830 0.0001

LEU 1830 MET 1831 -0.0001

MET 1831 LYS 1832 -0.0001

LYS 1832 LYS 1833 -0.0000

LYS 1833 ALA 1834 -0.0108

ALA 1834 GLU 1835 -0.0001

GLU 1835 GLU 1836 -0.0002

GLU 1836 GLY 1837 0.0002

GLY 1837 ASP 1838 0.0001

ASP 1838 LEU 1839 -0.0001

LEU 1839 LEU 1840 0.0001

LEU 1840 VAL 1841 0.0001

VAL 1841 ASN 1842 -0.0000

ASN 1842 PRO 1843 0.0005

PRO 1843 ASP 1844 -0.0000

ASP 1844 GLN 1845 -0.0001

GLN 1845 PRO 1846 0.0003

PRO 1846 ARG 1847 -0.0001

ARG 1847 LEU 1848 -0.0000

LEU 1848 THR 1849 -0.0002

THR 1849 ILE 1850 0.0000

ILE 1850 PRO 1851 -0.0000

PRO 1851 ILE 1852 0.0022

ILE 1852 SER 1853 0.0002

SER 1853 GLN 1854 0.0000

GLN 1854 ILE 1855 -0.0002

ILE 1855 ALA 1856 -0.0001

ALA 1856 PRO 1857 0.0002

PRO 1857 ASP 1858 0.0001

ASP 1858 LEU 1859 -0.0002

LEU 1859 ILE 1860 -0.0002

ILE 1860 LEU 1861 0.0155

LEU 1861 ALA 1862 -0.0003

ALA 1862 ASP 1863 -0.0001

ASP 1863 LEU 1864 0.0001

LEU 1864 PRO 1865 -0.0003

PRO 1865 ARG 1866 0.0002

ARG 1866 ASN 1867 0.0002

ASN 1867 ILE 1868 -0.0002

ILE 1868 MET 1869 -0.0002

MET 1869 LEU 1870 -0.0106

LEU 1870 ASN 1871 -0.0002

ASN 1871 ASN 1872 0.0004

ASN 1872 ASP 1873 -0.0001

ASP 1873 GLU 1874 -0.0001

GLU 1874 LEU 1875 0.0001

LEU 1875 GLU 1876 0.0002

GLU 1876 PHE 1877 -0.0001

PHE 1877 GLU 1878 0.0002

GLU 1878 GLN 1879 0.0010

GLN 1879 ALA 1880 -0.0003

ALA 1880 PRO 1881 0.0000

PRO 1881 GLU 1882 0.0001

GLU 1882 PHE 1883 -0.0002

PHE 1883 LEU 1884 0.0001

LEU 1884 LEU 1885 0.0002

LEU 1885 GLY 1886 -0.0004

GLY 1886 ASP 1887 0.0000

ASP 1887 GLY 1888 0.0008

GLY 1888 SER 1889 0.0001

SER 1889 PHE 1890 -0.0001

PHE 1890 GLY 1891 -0.0002

GLY 1891 SER 1892 0.0003

SER 1892 VAL 1893 -0.0000

VAL 1893 TYR 1894 -0.0001

TYR 1894 ARG 1895 -0.0000

ARG 1895 ALA 1896 0.0004

ALA 1896 ALA 1897 -0.0032

ALA 1897 TYR 1898 -0.0004

TYR 1898 GLU 1899 0.0002

GLU 1899 GLY 1900 0.0002

GLY 1900 GLU 1901 0.0000

GLU 1901 GLU 1902 -0.0000

GLU 1902 VAL 1903 -0.0002

VAL 1903 ALA 1904 -0.0000

ALA 1904 VAL 1905 0.0000

VAL 1905 LYS 1906 0.0044

LYS 1906 ILE 1907 0.0001

ILE 1907 PHE 1908 -0.0000

PHE 1908 ASN 1909 0.0002

ASN 1909 LYS 1910 0.0000

LYS 1910 HIS 1911 0.0002

HIS 1911 THR 1912 0.0003

THR 1912 SER 1913 -0.0002

SER 1913 LEU 1914 0.0000

LEU 1914 ARG 1915 -0.0004

ARG 1915 LEU 1916 -0.0001

LEU 1916 LEU 1917 -0.0001

LEU 1917 ARG 1918 -0.0002

ARG 1918 GLN 1919 -0.0001

GLN 1919 GLU 1920 -0.0001

GLU 1920 LEU 1921 0.0001

LEU 1921 VAL 1922 0.0003

VAL 1922 VAL 1923 0.0000

VAL 1923 LEU 1924 0.0041

LEU 1924 CYS 1925 -0.0001

CYS 1925 HIS 1926 0.0003

HIS 1926 LEU 1927 0.0004

LEU 1927 HIS 1928 0.0000

HIS 1928 HIS 1929 -0.0002

HIS 1929 PRO 1930 0.0000

PRO 1930 SER 1931 0.0001

SER 1931 LEU 1932 -0.0000

LEU 1932 ILE 1933 0.0081

ILE 1933 SER 1934 -0.0002

SER 1934 LEU 1935 -0.0003

LEU 1935 LEU 1936 0.0001

LEU 1936 ALA 1937 -0.0001

ALA 1937 ALA 1938 -0.0000

ALA 1938 GLY 1939 0.0000

GLY 1939 ILE 1940 -0.0002

ILE 1940 ARG 1941 -0.0000

ARG 1941 PRO 1942 -0.0069

PRO 1942 ARG 1943 -0.0002

ARG 1943 MET 1944 0.0001

MET 1944 LEU 1945 -0.0002

LEU 1945 VAL 1946 0.0001

VAL 1946 MET 1947 0.0004

MET 1947 GLU 1948 -0.0001

GLU 1948 LEU 1949 -0.0001

LEU 1949 ALA 1950 -0.0002

ALA 1950 SER 1951 0.0014

SER 1951 LYS 1952 -0.0000

LYS 1952 GLY 1953 0.0004

GLY 1953 SER 1954 -0.0005

SER 1954 LEU 1955 0.0004

LEU 1955 ASP 1956 0.0000

ASP 1956 ARG 1957 -0.0001

ARG 1957 LEU 1958 0.0000

LEU 1958 LEU 1959 -0.0001

LEU 1959 GLN 1960 0.0056

GLN 1960 GLN 1961 0.0001

GLN 1961 ASP 1962 0.0000

ASP 1962 LYS 1963 -0.0002

LYS 1963 ALA 1964 0.0003

ALA 1964 SER 1965 -0.0002

SER 1965 LEU 1966 -0.0002

LEU 1966 THR 1967 0.0003

THR 1967 ARG 1968 0.0001

ARG 1968 THR 1969 -0.0132

THR 1969 LEU 1970 0.0001

LEU 1970 GLN 1971 -0.0004

GLN 1971 HIS 1972 0.0000

HIS 1972 ARG 1973 0.0001

ARG 1973 ILE 1974 -0.0002

ILE 1974 ALA 1975 0.0000

ALA 1975 LEU 1976 -0.0001

LEU 1976 HIS 1977 0.0001

HIS 1977 VAL 1978 0.0024

VAL 1978 ALA 1979 0.0003

ALA 1979 ASP 1980 -0.0001

ASP 1980 GLY 1981 0.0002

GLY 1981 LEU 1982 0.0002

LEU 1982 ARG 1983 0.0001

ARG 1983 TYR 1984 0.0002

TYR 1984 LEU 1985 -0.0003

LEU 1985 HIS 1986 -0.0000

HIS 1986 SER 1987 -0.0046

SER 1987 ALA 1988 -0.0001

ALA 1988 MET 1989 0.0000

MET 1989 ILE 1990 0.0001

ILE 1990 ILE 1991 0.0001

ILE 1991 TYR 1992 0.0004

TYR 1992 ARG 1993 -0.0005

ARG 1993 ASP 1994 -0.0001

ASP 1994 LEU 1995 -0.0000

LEU 1995 LYS 1996 0.0013

LYS 1996 PRO 1997 -0.0004

PRO 1997 HIS 1998 -0.0005

HIS 1998 ASN 1999 -0.0001

ASN 1999 VAL 2000 -0.0001

VAL 2000 LEU 2001 0.0002

LEU 2001 LEU 2002 -0.0003

LEU 2002 PHE 2003 0.0002

PHE 2003 THR 2004 -0.0001

THR 2004 LEU 2005 0.0111

LEU 2005 TYR 2006 0.0001

TYR 2006 PRO 2007 0.0002

PRO 2007 ASN 2008 -0.0000

ASN 2008 ALA 2009 -0.0002

ALA 2009 ALA 2010 -0.0001

ALA 2010 ILE 2011 0.0003

ILE 2011 ILE 2012 0.0002

ILE 2012 ALA 2013 -0.0000

ALA 2013 LYS 2014 0.0070

LYS 2014 ILE 2015 -0.0001

ILE 2015 ALA 2016 0.0001

ALA 2016 ASP 2017 -0.0001

ASP 2017 TYR 2018 0.0001

TYR 2018 GLY 2019 0.0001

GLY 2019 ILE 2020 -0.0002

ILE 2020 ALA 2021 -0.0004

ALA 2021 GLN 2022 0.0001

GLN 2022 TYR 2023 0.0021

TYR 2023 CYS 2024 0.0002

CYS 2024 CYS 2025 -0.0000

CYS 2025 ARG 2026 -0.0000

ARG 2026 MET 2027 0.0000

MET 2027 THR 2031 -0.0039

THR 2031 SER 2032 0.0002

SER 2032 GLU 2033 -0.0003

GLU 2033 GLY 2034 -0.0001

GLY 2034 THR 2035 -0.0002

THR 2035 PRO 2036 -0.0000

PRO 2036 GLY 2037 -0.0003

GLY 2037 PHE 2038 0.0002

PHE 2038 ARG 2039 0.0000

ARG 2039 ALA 2040 -0.0091

ALA 2040 PRO 2041 -0.0002

PRO 2041 GLU 2042 -0.0002

GLU 2042 VAL 2043 -0.0001

VAL 2043 ALA 2044 -0.0003

ALA 2044 ARG 2045 -0.0003

ARG 2045 GLY 2046 -0.0004

GLY 2046 ASN 2047 -0.0001

ASN 2047 VAL 2048 0.0003

VAL 2048 ILE 2049 0.0099

ILE 2049 TYR 2050 -0.0002

TYR 2050 ASN 2051 0.0002

ASN 2051 GLN 2052 -0.0003

GLN 2052 GLN 2053 -0.0002

GLN 2053 ALA 2054 0.0003

ALA 2054 ASP 2055 0.0000

ASP 2055 VAL 2056 0.0003

VAL 2056 TYR 2057 -0.0005

TYR 2057 SER 2058 0.0117

SER 2058 PHE 2059 0.0001

PHE 2059 GLY 2060 0.0001

GLY 2060 LEU 2061 -0.0000

LEU 2061 LEU 2062 0.0001

LEU 2062 LEU 2063 -0.0001

LEU 2063 TYR 2064 -0.0003

TYR 2064 ASP 2065 0.0000

ASP 2065 ILE 2066 -0.0003

ILE 2066 LEU 2067 -0.0005

LEU 2067 THR 2068 -0.0005

THR 2068 THR 2069 0.0001

THR 2069 GLY 2070 -0.0001

GLY 2070 GLY 2071 0.0003

GLY 2071 ARG 2072 0.0000

ARG 2072 ILE 2073 0.0000

ILE 2073 VAL 2074 0.0002

VAL 2074 GLU 2075 0.0002

GLU 2075 GLY 2076 -0.0066

GLY 2076 LEU 2077 -0.0002

LEU 2077 LYS 2078 0.0004

LYS 2078 PHE 2079 -0.0001

PHE 2079 PRO 2080 0.0001

PRO 2080 ASN 2081 -0.0002

ASN 2081 GLU 2082 -0.0002

GLU 2082 PHE 2083 0.0000

PHE 2083 ASP 2084 -0.0000

ASP 2084 GLU 2085 0.0037

GLU 2085 LEU 2086 0.0000

LEU 2086 GLU 2087 -0.0002

GLU 2087 ILE 2088 0.0001

ILE 2088 GLN 2089 -0.0002

GLN 2089 GLY 2090 0.0003

GLY 2090 LYS 2091 0.0002

LYS 2091 LEU 2092 -0.0001

LEU 2092 PRO 2093 0.0000

PRO 2093 ASP 2094 -0.0407

ASP 2094 PRO 2095 0.0003

PRO 2095 VAL 2096 -0.0001

VAL 2096 LYS 2097 -0.0003

LYS 2097 GLU 2098 0.0000

GLU 2098 TYR 2099 0.0000

TYR 2099 GLY 2100 0.0000

GLY 2100 CYS 2101 0.0000

CYS 2101 ALA 2102 0.0000

ALA 2102 PRO 2103 0.0351

PRO 2103 TRP 2104 0.0002

TRP 2104 PRO 2105 -0.0005

PRO 2105 MET 2106 0.0001

MET 2106 VAL 2107 0.0001

VAL 2107 GLU 2108 -0.0004

GLU 2108 LYS 2109 -0.0001

LYS 2109 LEU 2110 0.0000

LEU 2110 ILE 2111 -0.0004

ILE 2111 LYS 2112 0.0147

LYS 2112 GLN 2113 0.0001

GLN 2113 CYS 2114 -0.0005

CYS 2114 LEU 2115 -0.0002

LEU 2115 LYS 2116 0.0001

LYS 2116 GLU 2117 -0.0001

GLU 2117 ASN 2118 0.0002

ASN 2118 PRO 2119 0.0001

PRO 2119 GLN 2120 0.0001

GLN 2120 GLU 2121 -0.0000

GLU 2121 ARG 2122 -0.0001

ARG 2122 PRO 2123 0.0002

PRO 2123 THR 2124 -0.0003

THR 2124 SER 2125 0.0003

SER 2125 ALA 2126 -0.0002

ALA 2126 GLN 2127 -0.0001

GLN 2127 VAL 2128 0.0004

VAL 2128 PHE 2129 0.0000

PHE 2129 ASP 2130 -0.0020

ASP 2130 ILE 2131 -0.0001

ILE 2131 LEU 2132 0.0004

LEU 2132 ASN 2133 -0.0000

ASN 2133 SER 2134 0.0002

SER 2134 ALA 2135 0.0004

ALA 2135 GLU 2136 0.0003

GLU 2136 LEU 2137 0.0001

LEU 2137 VAL 2138 0.0004

VAL 2138 CYS 2139 0.0365

CYS 2139 LEU 2140 0.0005

LEU 2140 THR 2141 -0.0001

THR 2141 ARG 2142 0.0002

ARG 2142 ARG 2143 -0.0005

ARG 2143 ILE 2144 -0.0000

ILE 2144 LEU 2145 0.0001

LEU 2145 LEU 2146 -0.0001

LEU 2146 PRO 2147 0.0003

PRO 2147 LYS 2148 0.0268

LYS 2148 ASN 2149 0.0000

ASN 2149 VAL 2150 -0.0002

VAL 2150 ILE 2151 0.0004

ILE 2151 VAL 2152 -0.0003

VAL 2152 GLU 2153 -0.0001

GLU 2153 CYS 2154 -0.0002

CYS 2154 MET 2155 -0.0000

MET 2155 VAL 2156 0.0002

VAL 2156 ALA 2157 0.0014

ALA 2157 THR 2158 -0.0004

THR 2158 HIS 2159 0.0002

HIS 2159 HIS 2160 0.0001

HIS 2160 ASN 2161 0.0000

ASN 2161 SER 2162 0.0001

SER 2162 ARG 2163 -0.0001

ARG 2163 ASN 2164 0.0001

ASN 2164 ALA 2165 0.0001

ALA 2165 SER 2166 0.0248

SER 2166 ILE 2167 -0.0002

ILE 2167 TRP 2168 0.0003

TRP 2168 LEU 2169 0.0000

LEU 2169 GLY 2170 0.0000

GLY 2170 CYS 2171 0.0001

CYS 2171 GLY 2172 -0.0002

GLY 2172 HIS 2173 0.0001

HIS 2173 THR 2174 -0.0001

THR 2174 ASP 2175 -0.0018

ASP 2175 ARG 2176 -0.0004

ARG 2176 GLY 2177 0.0000

GLY 2177 GLN 2178 -0.0001

GLN 2178 LEU 2179 0.0003

LEU 2179 SER 2180 0.0002

SER 2180 PHE 2181 0.0002

PHE 2181 LEU 2182 -0.0001

LEU 2182 ASP 2183 0.0000

ASP 2183 LEU 2184 -0.0082

LEU 2184 ASN 2185 -0.0001

ASN 2185 THR 2186 0.0004

THR 2186 GLU 2187 -0.0001

GLU 2187 GLY 2188 -0.0002

GLY 2188 TYR 2189 0.0000

TYR 2189 THR 2190 -0.0001

THR 2190 SER 2191 -0.0002

SER 2191 GLU 2192 0.0002

GLU 2192 GLU 2193 0.0004

GLU 2193 VAL 2194 0.0001

VAL 2194 ALA 2195 -0.0003

ALA 2195 ASP 2196 0.0002

ASP 2196 SER 2197 0.0002

SER 2197 ARG 2198 -0.0002

ARG 2198 ILE 2199 0.0002

ILE 2199 LEU 2200 0.0001

LEU 2200 CYS 2201 0.0001

CYS 2201 LEU 2202 0.0024

LEU 2202 ALA 2203 0.0001

ALA 2203 LEU 2204 0.0002

LEU 2204 VAL 2205 -0.0001

VAL 2205 HIS 2206 0.0002

HIS 2206 LEU 2207 0.0000

LEU 2207 PRO 2208 0.0001

PRO 2208 VAL 2209 0.0002

VAL 2209 GLU 2210 -0.0001

GLU 2210 LYS 2211 -0.0048

LYS 2211 GLU 2212 0.0001

GLU 2212 SER 2213 0.0000

SER 2213 TRP 2214 0.0000

TRP 2214 ILE 2215 0.0001

ILE 2215 VAL 2216 -0.0001

VAL 2216 SER 2217 0.0003

SER 2217 GLY 2218 -0.0003

GLY 2218 THR 2219 -0.0001

THR 2219 GLN 2220 -0.0008

GLN 2220 SER 2221 0.0004

SER 2221 GLY 2222 -0.0002

GLY 2222 THR 2223 -0.0000

THR 2223 LEU 2224 0.0002

LEU 2224 LEU 2225 0.0003

LEU 2225 VAL 2226 0.0002

VAL 2226 ILE 2227 -0.0001

ILE 2227 ASN 2228 -0.0003

ASN 2228 THR 2229 0.0004

THR 2229 GLU 2230 0.0001

GLU 2230 ASP 2231 -0.0003

ASP 2231 GLY 2232 -0.0001

GLY 2232 LYS 2233 -0.0003

LYS 2233 LYS 2234 -0.0002

LYS 2234 ARG 2235 0.0001

ARG 2235 HIS 2236 -0.0001

HIS 2236 THR 2237 -0.0000

THR 2237 LEU 2238 0.0017

LEU 2238 GLU 2239 0.0001

GLU 2239 LYS 2240 -0.0003

LYS 2240 MET 2241 0.0000

MET 2241 THR 2242 0.0000

THR 2242 ASP 2243 0.0005

ASP 2243 SER 2244 -0.0000

SER 2244 VAL 2245 -0.0000

VAL 2245 THR 2246 -0.0000

THR 2246 CYS 2247 0.0018

CYS 2247 LEU 2248 -0.0002

LEU 2248 TYR 2249 0.0003

TYR 2249 CYS 2250 0.0000

CYS 2250 ASN 2251 0.0000

ASN 2251 SER 2252 -0.0002

SER 2252 PHE 2253 0.0002

PHE 2253 SER 2254 -0.0003

SER 2254 LYS 2255 0.0002

LYS 2255 GLN 2256 0.0036

GLN 2256 SER 2257 0.0003

SER 2257 LYS 2258 -0.0000

LYS 2258 GLN 2259 0.0001

GLN 2259 LYS 2260 -0.0001

LYS 2260 ASN 2261 0.0001

ASN 2261 PHE 2262 -0.0001

PHE 2262 LEU 2263 0.0000

LEU 2263 LEU 2264 0.0002

LEU 2264 VAL 2265 0.0042

VAL 2265 GLY 2266 -0.0002

GLY 2266 THR 2267 0.0002

THR 2267 ALA 2268 -0.0002

ALA 2268 ASP 2269 0.0005

ASP 2269 GLY 2270 0.0002

GLY 2270 LYS 2271 0.0002

LYS 2271 LEU 2272 -0.0000

LEU 2272 ALA 2273 0.0001

ALA 2273 ILE 2274 -0.0015

ILE 2274 PHE 2275 -0.0001

PHE 2275 GLU 2276 0.0000

GLU 2276 ASP 2277 0.0000

ASP 2277 LYS 2278 0.0003

LYS 2278 THR 2279 0.0002

THR 2279 VAL 2280 0.0001

VAL 2280 LYS 2281 0.0004

LYS 2281 LEU 2282 -0.0002

LEU 2282 LYS 2283 0.0026

LYS 2283 GLY 2284 0.0003

GLY 2284 ALA 2285 0.0003

ALA 2285 ALA 2286 -0.0003

ALA 2286 PRO 2287 0.0001

PRO 2287 LEU 2288 -0.0002

LEU 2288 LYS 2289 -0.0003

LYS 2289 ILE 2290 0.0003

ILE 2290 LEU 2291 -0.0002

LEU 2291 ASN 2292 -0.0005

ASN 2292 ILE 2293 -0.0000

ILE 2293 GLY 2294 -0.0002

GLY 2294 ASN 2295 0.0002

ASN 2295 VAL 2296 -0.0002

VAL 2296 SER 2297 0.0002

SER 2297 THR 2298 -0.0001

THR 2298 PRO 2299 -0.0002

PRO 2299 LEU 2300 0.0004

LEU 2300 MET 2301 0.0028

MET 2301 CYS 2302 0.0000

CYS 2302 LEU 2303 0.0003

LEU 2303 SER 2304 0.0001

SER 2304 GLU 2305 -0.0001

GLU 2305 SER 2306 -0.0000

SER 2306 THR 2307 0.0000

THR 2307 ASN 2308 0.0002

ASN 2308 SER 2309 -0.0003

SER 2309 THR 2310 -0.0063

THR 2310 GLU 2311 -0.0001

GLU 2311 ARG 2312 0.0001

ARG 2312 ASN 2313 0.0002

ASN 2313 VAL 2314 -0.0002

VAL 2314 MET 2315 -0.0002

MET 2315 TRP 2316 0.0003

TRP 2316 GLY 2317 0.0003

GLY 2317 GLY 2318 0.0000

GLY 2318 CYS 2319 0.0033

CYS 2319 GLY 2320 -0.0002

GLY 2320 THR 2321 0.0000

THR 2321 LYS 2322 -0.0002

LYS 2322 ILE 2323 -0.0002

ILE 2323 PHE 2324 -0.0004

PHE 2324 SER 2325 0.0001

SER 2325 PHE 2326 0.0001

PHE 2326 SER 2327 0.0001

SER 2327 ASN 2328 0.0006

ASN 2328 ASP 2329 0.0006

ASP 2329 PHE 2330 0.0003

PHE 2330 THR 2331 -0.0002

THR 2331 ILE 2332 -0.0000

ILE 2332 GLN 2333 0.0004

GLN 2333 LYS 2334 0.0004

LYS 2334 LEU 2335 -0.0002

LEU 2335 ILE 2336 -0.0003

ILE 2336 GLU 2337 -0.0020

GLU 2337 THR 2338 0.0001

THR 2338 ARG 2339 0.0000

ARG 2339 THR 2340 -0.0000

THR 2340 SER 2341 -0.0001

SER 2341 GLN 2342 0.0004

GLN 2342 LEU 2343 -0.0005

LEU 2343 PHE 2344 -0.0000

PHE 2344 SER 2345 0.0003

SER 2345 TYR 2346 0.0006

TYR 2346 ALA 2347 -0.0000

ALA 2347 ALA 2348 0.0001

ALA 2348 PHE 2349 -0.0004

PHE 2349 SER 2350 -0.0000

SER 2350 ASP 2351 0.0000

ASP 2351 SER 2352 -0.0001

SER 2352 ASN 2353 0.0001

ASN 2353 ILE 2354 0.0004

ILE 2354 ILE 2355 -0.0032

ILE 2355 THR 2356 0.0002

THR 2356 VAL 2357 0.0001

VAL 2357 VAL 2358 0.0000

VAL 2358 VAL 2359 0.0002

VAL 2359 ASP 2360 -0.0001

ASP 2360 THR 2361 -0.0002

THR 2361 ALA 2362 -0.0001

ALA 2362 LEU 2363 0.0002

LEU 2363 TYR 2364 0.0046

TYR 2364 ILE 2365 -0.0002

ILE 2365 ALA 2366 -0.0001

ALA 2366 LYS 2367 0.0001

LYS 2367 GLN 2368 -0.0001

GLN 2368 ASN 2369 0.0001

ASN 2369 SER 2370 0.0001

SER 2370 PRO 2371 0.0001

PRO 2371 VAL 2372 -0.0005

VAL 2372 VAL 2373 -0.0001

VAL 2373 GLU 2374 0.0003

GLU 2374 VAL 2375 -0.0003

VAL 2375 TRP 2376 0.0003

TRP 2376 ASP 2377 0.0002

ASP 2377 LYS 2378 -0.0002

LYS 2378 LYS 2379 -0.0002

LYS 2379 THR 2380 0.0001

THR 2380 GLU 2381 -0.0001

GLU 2381 LYS 2382 0.0087

LYS 2382 LEU 2383 -0.0002

LEU 2383 CYS 2384 -0.0004

CYS 2384 GLY 2385 0.0001

GLY 2385 LEU 2386 0.0000

LEU 2386 ILE 2387 0.0002

ILE 2387 ASP 2388 -0.0001

ASP 2388 CYS 2389 -0.0002

CYS 2389 VAL 2390 0.0002

VAL 2390 HIS 2391 -0.0224

HIS 2391 PHE 2392 0.0003

PHE 2392 LEU 2393 0.0002

LEU 2393 ARG 2394 -0.0002

ARG 2394 GLU 2395 0.0001

GLU 2395 VAL 2396 -0.0002

VAL 2396 THR 2397 0.0002

THR 2397 VAL 2398 -0.0002

VAL 2398 LYS 2399 0.0001

LYS 2399 GLU 2400 -0.0000

GLU 2400 ASN 2401 -0.0001

ASN 2401 LYS 2402 -0.0002

LYS 2402 GLU 2403 -0.0002

GLU 2403 SER 2404 0.0003

SER 2404 LYS 2405 -0.0001

LYS 2405 HIS 2406 -0.0004

HIS 2406 LYS 2407 -0.0002

LYS 2407 MET 2408 0.0005

MET 2408 SER 2409 0.0040

SER 2409 TYR 2410 0.0003

TYR 2410 SER 2411 -0.0003

SER 2411 GLY 2412 -0.0002

GLY 2412 ARG 2413 0.0003

ARG 2413 VAL 2414 -0.0003

VAL 2414 LYS 2415 -0.0004

LYS 2415 THR 2416 0.0000

THR 2416 LEU 2417 0.0002

LEU 2417 CYS 2418 0.0109

CYS 2418 LEU 2419 0.0002

LEU 2419 GLN 2420 0.0002

GLN 2420 LYS 2421 0.0001

LYS 2421 ASN 2422 0.0005

ASN 2422 THR 2423 0.0001

THR 2423 ALA 2424 -0.0002

ALA 2424 LEU 2425 0.0001

LEU 2425 TRP 2426 0.0003

TRP 2426 ILE 2427 0.0013

ILE 2427 GLY 2428 -0.0000

GLY 2428 THR 2429 -0.0001

THR 2429 GLY 2430 -0.0002

GLY 2430 GLY 2431 -0.0000

GLY 2431 GLY 2432 -0.0003

GLY 2432 HIS 2433 0.0002

HIS 2433 ILE 2434 0.0001

ILE 2434 LEU 2435 0.0001

LEU 2435 LEU 2436 -0.0104

LEU 2436 LEU 2437 -0.0000

LEU 2437 ASP 2438 0.0002

ASP 2438 LEU 2439 0.0004

LEU 2439 SER 2440 0.0002

SER 2440 THR 2441 -0.0001

THR 2441 ARG 2442 0.0001

ARG 2442 ARG 2443 -0.0002

ARG 2443 LEU 2444 0.0002

LEU 2444 ILE 2445 0.0004

ILE 2445 ARG 2446 -0.0003

ARG 2446 VAL 2447 -0.0000

VAL 2447 ILE 2448 -0.0004

ILE 2448 TYR 2449 0.0002

TYR 2449 ASN 2450 0.0001

ASN 2450 PHE 2451 -0.0001

PHE 2451 CYS 2452 0.0000

CYS 2452 ASN 2453 0.0000

ASN 2453 SER 2454 -0.0106

SER 2454 VAL 2455 -0.0003

VAL 2455 ARG 2456 0.0000

ARG 2456 VAL 2457 0.0004

VAL 2457 MET 2458 0.0001

MET 2458 MET 2459 -0.0004

MET 2459 THR 2460 0.0001

THR 2460 ALA 2461 0.0002

ALA 2461 GLN 2462 0.0000

GLN 2462 LEU 2463 -0.0248

LEU 2463 GLY 2464 -0.0001

GLY 2464 SER 2465 -0.0003

SER 2465 LEU 2466 0.0003

LEU 2466 LYS 2467 -0.0003

LYS 2467 ASN 2468 -0.0002

ASN 2468 VAL 2469 0.0001

VAL 2469 MET 2470 0.0001

MET 2470 LEU 2471 -0.0001

LEU 2471 VAL 2472 0.0122

VAL 2472 LEU 2473 -0.0001

LEU 2473 GLY 2474 0.0001

GLY 2474 TYR 2475 -0.0004

TYR 2475 ASN 2476 0.0005

ASN 2476 ARG 2477 -0.0001

ARG 2477 LYS 2478 0.0004

LYS 2478 ASN 2479 -0.0003

ASN 2479 THR 2480 -0.0002

THR 2480 GLU 2481 -0.0013

GLU 2481 GLY 2482 -0.0000

GLY 2482 THR 2483 -0.0002

THR 2483 GLN 2484 -0.0000

GLN 2484 LYS 2485 0.0002

LYS 2485 GLN 2486 0.0002

GLN 2486 LYS 2487 -0.0000

LYS 2487 GLU 2488 0.0001

GLU 2488 ILE 2489 0.0000

ILE 2489 GLN 2490 0.0114

GLN 2490 SER 2491 -0.0003

SER 2491 CYS 2492 0.0000

CYS 2492 LEU 2493 0.0001

LEU 2493 THR 2494 0.0000

THR 2494 VAL 2495 -0.0003

VAL 2495 TRP 2496 0.0001

TRP 2496 ASP 2497 0.0002

ASP 2497 ILE 2498 0.0001

ILE 2498 ASN 2499 0.0946

ASN 2499 LEU 2500 0.0002

LEU 2500 PRO 2501 0.0006

PRO 2501 HIS 2502 -0.0004

HIS 2502 GLU 2503 0.0001

GLU 2503 VAL 2504 0.0001

VAL 2504 GLN 2505 -0.0002

GLN 2505 ASN 2506 -0.0004

ASN 2506 LEU 2507 0.0003

LEU 2507 GLU 2508 -0.0031

GLU 2508 LYS 2509 0.0001

LYS 2509 HIS 2510 0.0002

HIS 2510 ILE 2511 -0.0000

ILE 2511 GLU 2512 0.0002

GLU 2512 VAL 2513 0.0001

VAL 2513 ARG 2514 -0.0001

ARG 2514 LYS 2515 0.0003

LYS 2515 GLU 2516 0.0003

GLU 2516 LEU 2517 0.0322

LEU 2517 ALA 2518 0.0005

ALA 2518 GLU 2519 0.0003

GLU 2519 LYS 2520 -0.0000

LYS 2520 MET 2521 -0.0002

MET 2521 ARG 2522 -0.0002

ARG 2522 ARG 2523 0.0001

ARG 2523 THR 2524 -0.0001

THR 2524 SER 2525 -0.0001

SER 2525 VAL 2526 -0.0008

VAL 2526 GLU 2527 -0.0000

If you find results from this site helpful for your research, please cite one of our papers:

K. Suhre & Y.H. Sanejouand, ElNemo: a normal mode web-server for protein movement analysis and the generation of templates for molecular replacement. Nucleic Acids Research, 32, W610-W614, 2004.
K. Suhre & Y.H. Sanejouand, On the potential of normal mode analysis for solving difficult molecular replacement problems. Acta Cryst. D vol.60, p796-799, 2004 © International Union of Crystallography.

elNémo is maintained by Yves-Henri Sanejouand.
It was developed by Karsten Suhre.
Between 2003 and 2014, it was hosted by IGS (Marseille).
Between 2015 and 2025, it was hosted by US2B (Nantes).
Last modification: april 24th, 2026.

Should you encounter any unexpected behaviour, please let us know. elNémo has been relocated. **Some cleaning from time to time** Sorry for the inconvenience.

*** LRRK2_7LI4_R1441C ***

CA strain for 2605160929253032129

--- normal mode 9 ---

Should you encounter any unexpected behaviour,
please let us know.
elNémo has been relocated.
Some cleaning from time to time
Sorry for the inconvenience.

* LRRK2_7LI4_R1441C *